{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:33:43Z","timestamp":1784774023105,"version":"3.55.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","arthroplastyjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Arthroplasty"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.arth.2015.06.005","type":"journal-article","created":{"date-parts":[[2015,6,14]],"date-time":"2015-06-14T17:03:27Z","timestamp":1434301407000},"page":"2196-2200","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Topical Application of Tranexamic Acid Plus Diluted Epinephrine Reduces Postoperative Hidden Blood Loss in Total Hip Arthroplasty"],"prefix":"10.1016","volume":"30","author":[{"given":"Fuqiang","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanshou","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zirong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arth.2015.06.005_bb0005","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.arth.2013.06.011","article-title":"Topical tranexamic acid reduces blood loss and transfusion rates in total hip and total knee arthroplasty","volume":"28","author":"Konig","year":"2013","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2015.06.005_bb0010","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2106\/00004623-199901000-00002","article-title":"An analysis of blood management in patients having a total hip or knee arthroplasty","volume":"81","author":"Bierbaum","year":"1999","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2015.06.005_bb0015","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1016\/j.arth.2012.04.024","article-title":"Tranexamic acid for reduction of blood loss during total hip arthroplasty","volume":"27","author":"Imai","year":"2012","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2015.06.005_bb0020","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1016\/j.arth.2014.07.019","article-title":"Comparison of topical and intravenous tranexamic acid on blood loss and transfusion rates in total hip arthroplasty","volume":"29","author":"Wei","year":"2014","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2015.06.005_bb0025","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.arth.2013.10.005","article-title":"Topical administration of tranexamic acid in primary total hip and total knee arthroplasty","volume":"29","author":"Martin","year":"2014","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2015.06.005_bb0030","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1016\/j.arth.2014.03.032","article-title":"Topical application of tranexamic acid in primary total hip arthroplasty: a randomized double-blind controlled trial","volume":"29","author":"Yue","year":"2014","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2015.06.005_bb0035","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.2106\/JBJS.L.00908","article-title":"Topical (intra-articular) tranexamic acid reduces blood loss and transfusion rates following total hip replacement a randomized controlled trial (TRANX-H)","volume":"95","author":"Alshryda","year":"2013","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2015.06.005_bb0040","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1056\/NEJMoa0800374","article-title":"Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty","volume":"358","author":"Eriksson","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.arth.2015.06.005_bb0045","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1056\/NEJMoa076016","article-title":"Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty","volume":"358","author":"Lassen","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.arth.2015.06.005_bb0050","first-page":"7","article-title":"Does epinephrine wash reduce blood loss in primary total hip replacements?","volume":"1","author":"Yewlett","year":"2014","journal-title":"Wales Orthop J"},{"key":"10.1016\/j.arth.2015.06.005_bb0055","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1302\/0301-620X.90B9.21115","article-title":"Strategies for blood management in orthopaedic and trauma surgery","volume":"90","author":"Lemaire","year":"2008","journal-title":"J Bone Joint Surg (Br)"},{"key":"10.1016\/j.arth.2015.06.005_bb0060","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1080\/00015458.2007.11680081","article-title":"Reduction of blood loss with tranexamic acid in primary total hip replacement surgery","volume":"107","author":"Claeys","year":"2007","journal-title":"Acta Chir Belg"},{"key":"10.1016\/j.arth.2015.06.005_bb0065","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1302\/0301-620X.91B6.22393","article-title":"The effect of an intravenous bolus of tranexamic acid on blood loss in total hip replacement","volume":"91","author":"Rajesparan","year":"2009","journal-title":"J Bone Joint Surg (Br)"},{"key":"10.1016\/j.arth.2015.06.005_bb0070","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00167-010-1263-5","article-title":"Efficient strategy for controlling postoperative hemorrhage in total knee arthroplasty","volume":"19","author":"Sasanuma","year":"2011","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.arth.2015.06.005_bb0075","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00264-005-0050-2","article-title":"Local infusion of norepinephrine reduces blood losses and need of transfusion in total knee arthroplasty","volume":"30","author":"Gasparini","year":"2006","journal-title":"Int Orthop"},{"key":"10.1016\/j.arth.2015.06.005_bb0080","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1302\/0301-620X.93B1.24984","article-title":"Systematic review and meta-analysis of the use of tranexamic acid in total hip replacement","volume":"93","author":"Sukeik","year":"2011","journal-title":"J Bone Joint Surg (Br)"},{"key":"10.1016\/j.arth.2015.06.005_bb0085","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1302\/0301-620X.96B8.33745","article-title":"A systematic review and meta-analysis of the topical administration of tranexamic acid in total hip and knee replacement","volume":"96-B","author":"Alshryda","year":"2014","journal-title":"Bone Joint J"},{"key":"10.1016\/j.arth.2015.06.005_bb0090","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ijsu.2014.12.023","article-title":"Topical application of tranexamic acid in primary total hip arthroplasty: a systemic review and meta-analysis","volume":"15","author":"Wang","year":"2015","journal-title":"Int J Surg"},{"key":"10.1016\/j.arth.2015.06.005_bb0095","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/00000542-198303000-00016","article-title":"Estimating allowable blood loss: corrected for dilution","volume":"58","author":"Gross","year":"1983","journal-title":"Anesthesiology"},{"key":"10.1016\/j.arth.2015.06.005_bb0100","first-page":"224","article-title":"Prediction of blood volume in normal human adults","volume":"51","author":"Nadler","year":"1962","journal-title":"Surgery"},{"key":"10.1016\/j.arth.2015.06.005_bb0105","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1302\/0301-620X.86B4.14508","article-title":"Hidden blood loss following hip and knee arthroplasty correct management of blood loss should take hidden loss into account","volume":"86","author":"Sehat","year":"2004","journal-title":"J Bone Joint Surg (Br)"},{"key":"10.1016\/j.arth.2015.06.005_bb0110","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s00590-014-1461-9","article-title":"The reduction in blood loss with intra-articular injection of tranexamic acid in unilateral total knee arthroplasty without operative drains: a randomized controlled trial","volume":"25","author":"Yang","year":"2015","journal-title":"Eur J Orthop Surg Traumatol"},{"key":"10.1016\/j.arth.2015.06.005_bb0115","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1302\/0301-620X.89B3.17565","article-title":"Comparison of topical fibrin spray and tranexamic acid on blood loss after total knee replacement: a prospective, randomised controlled trial","volume":"89","author":"Molloy","year":"2007","journal-title":"J Bone Joint Surg (Br)"},{"key":"10.1016\/j.arth.2015.06.005_bb0120","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3928\/01477447-20091124-30","article-title":"The effect of tranexamic acid on reducing blood loss in cementless total hip arthroplasty under epidural anesthesia","volume":"33","author":"Kazemi","year":"2010","journal-title":"Orthopedics"},{"key":"10.1016\/j.arth.2015.06.005_bb0125","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1007\/s00264-010-1205-3","article-title":"Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty","volume":"35","author":"Ishida","year":"2011","journal-title":"Int Orthop"},{"key":"10.1016\/j.arth.2015.06.005_bb0130","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.2106\/00004623-198264080-00023","article-title":"Hemostatic changes and postoperative deep-vein thrombosis associated with use of a pneumatic tourniquet","volume":"64","author":"Price","year":"1982","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2015.06.005_bb0135","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3928\/01477447-20110427-11","article-title":"Chemoprophylaxis without intra-articular wound drainage can replace autotransfusion in primary TKA","volume":"34","author":"Hourlier","year":"2011","journal-title":"Orthopedics"},{"key":"10.1016\/j.arth.2015.06.005_bb0140","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1056\/NEJM199807233390407","article-title":"Hemostatic drugs","volume":"339","author":"Mannucci","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.arth.2015.06.005_bb0145","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0049-3848(00)00353-4","article-title":"Epinephrine induced platelet aggregation in rat platelet-rich plasma","volume":"100","author":"Yun-Choi","year":"2000","journal-title":"Thromb Res"},{"key":"10.1016\/j.arth.2015.06.005_bb0150","article-title":"Topical administration of tranexamic acid plus diluted-epinephrine in primary total knee arthroplasty: a randomized double-blinded controlled trial","author":"Gao","year":"2015","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2015.06.005_bb0155","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.arth.2013.09.005","article-title":"Topical tranexamic acid reduces transfusion rates in total hip and knee arthroplasty","volume":"29","author":"Gilbody","year":"2014","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2015.06.005_bb0160","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1055\/s-0030-1247737","article-title":"Reduced blood loss after total knee arthroplasty with local injection of bupivacaine and epinephrine","volume":"22","author":"Anderson","year":"2009","journal-title":"J Knee Surg"},{"key":"10.1016\/j.arth.2015.06.005_bb0165","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3928\/01477447-20090201-20","article-title":"The effect of intra-articular epinephrine lavage on blood loss following total knee arthroplasty","volume":"32","author":"Malone","year":"2009","journal-title":"Orthopedics"}],"container-title":["The Journal of Arthroplasty"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540315005148?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540315005148?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T03:29:51Z","timestamp":1652412591000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883540315005148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0883540315005148"],"URL":"https:\/\/doi.org\/10.1016\/j.arth.2015.06.005","relation":{},"ISSN":["0883-5403"],"issn-type":[{"value":"0883-5403","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Topical Application of Tranexamic Acid Plus Diluted Epinephrine Reduces Postoperative Hidden Blood Loss in Total Hip Arthroplasty","name":"articletitle","label":"Article Title"},{"value":"The Journal of Arthroplasty","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arth.2015.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}