{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:17:44Z","timestamp":1791001064510,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","arthroplastyjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Arthroplasty"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.arth.2016.12.049","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T03:16:36Z","timestamp":1484190996000},"page":"1698-1708","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":96,"title":["Evidence for the Use of Cell-Based Therapy for the Treatment of Osteonecrosis of the Femoral Head: A Systematic Review of the Literature"],"prefix":"10.1016","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3007-7538","authenticated-orcid":false,"given":"Nicolas S.","family":"Piuzzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Chahla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Schrock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"LaPrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Pascual-Garrido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Mont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George F.","family":"Muschler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arth.2016.12.049_bib1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.2106\/00004623-199503000-00018","article-title":"Non-traumatic avascular necrosis of the femoral head","volume":"77","author":"Mont","year":"1995","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2016.12.049_bib2","doi-asserted-by":"crossref","first-page":"590","DOI":"10.5312\/wjo.v6.i8.590","article-title":"Current concepts on osteonecrosis of the femoral head","volume":"6","author":"Moya-Angeler","year":"2015","journal-title":"World J Orthop"},{"key":"10.1016\/j.arth.2016.12.049_bib3","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s12178-015-9277-8","article-title":"Pathophysiology and risk factors for osteonecrosis","volume":"8","author":"Shah","year":"2015","journal-title":"Curr Rev Musculoskelet Med"},{"key":"10.1016\/j.arth.2016.12.049_bib4","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.2106\/JBJS.I.00575","article-title":"The natural history of untreated asymptomatic osteonecrosis of the femoral head: a systematic literature review","volume":"92","author":"Mont","year":"2010","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2016.12.049_bib5","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13287-015-0105-2","article-title":"Efficacy of autologous stem cell-based therapy for osteonecrosis of the femoral head in sickle cell disease: a five-year follow-up study","volume":"6","author":"Daltro","year":"2015","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.arth.2016.12.049_bib6","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s12178-015-9280-0","article-title":"A\u00a0current review of core decompression in the treatment of osteonecrosis of the femoral head","volume":"8","author":"Pierce","year":"2015","journal-title":"Curr Rev Musculoskelet Med"},{"key":"10.1016\/j.arth.2016.12.049_bib7","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1302\/0301-620X.77B6.7593097","article-title":"Preventing collapse in early osteonecrosis of the femoral head. A randomised clinical trial of core decompression","volume":"77","author":"Koo","year":"1995","journal-title":"J\u00a0Bone Joint Surg Br"},{"key":"10.1016\/j.arth.2016.12.049_bib8","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.2106\/00004623-200706000-00006","article-title":"Current practices of AAHKS members in the treatment of adult osteonecrosis of the femoral head","volume":"89","author":"McGrory","year":"2007","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2016.12.049_bib9","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1634\/stemcells.19-3-180","article-title":"Bone marrow stromal stem cells: nature, biology, and potential applications","volume":"19","author":"Bianco","year":"2001","journal-title":"Stem Cells"},{"key":"10.1016\/j.arth.2016.12.049_bib10","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bone.2014.04.034","article-title":"Osteonecrosis repair with bone marrow cell therapies: state of the clinical art","volume":"70","author":"Hernigou","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.arth.2016.12.049_bib11","doi-asserted-by":"crossref","first-page":"264","DOI":"10.7326\/0003-4819-151-4-200908180-00135","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"151","author":"Moher","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.arth.2016.12.049_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2106\/00004623-200301000-00001","article-title":"Introducing levels of evidence to the journal","volume":"85-A","author":"Wright","year":"2003","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2016.12.049_bib13","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1177\/0363546513497567","article-title":"How to write a systematic review","volume":"42","author":"Harris","year":"2014","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.arth.2016.12.049_bib14","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.2106\/00004623-200406000-00006","article-title":"Treatment of osteonecrosis of the femoral head with implantation of autologous bone-marrow cells. A pilot study","volume":"86","author":"Gangji","year":"2004","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2016.12.049_bib15","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s12306-013-0273-0","article-title":"Intralesional autologous mesenchymal stem cells in management of osteonecrosis of femur: a preliminary study","volume":"97","author":"Rastogi","year":"2013","journal-title":"Musculoskelet Surg"},{"key":"10.1016\/j.arth.2016.12.049_bib16","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.arth.2011.08.008","article-title":"Early results of core decompression and autologous bone marrow mononuclear cells instillation in femoral head osteonecrosis. A randomized control study","volume":"27","author":"Sen","year":"2012","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2016.12.049_bib17","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/jbmr.2390","article-title":"Combination treatment of biomechanical support and targeted intra-arterial infusion of peripheral blood stem cells mobilized by granulocyte-colony stimulating factor for the osteonecrosis of the femoral head: a randomized controlled clinical trial","volume":"30","author":"Mao","year":"2015","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.arth.2016.12.049_bib18","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/scrt505","article-title":"Efficacy of autologous bone marrow buffy coat grafting combined with core decompression in patients with avascular necrosis of femoral head: a prospective, double-blinded, randomized, controlled study","volume":"5","author":"Ma","year":"2014","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.arth.2016.12.049_bib19","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.bone.2011.11.002","article-title":"Treatment of early stage osteonecrosis of the femoral head with autologous implantation of bone marrow-derived and cultured mesenchymal stem cells","volume":"50","author":"Zhao","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.arth.2016.12.049_bib20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.arth.2015.06.022","article-title":"Combining concentrated autologous bone marrow stem cells injection with core decompression improves outcome for patients with early-stage osteonecrosis of the femoral head: a comparative study","volume":"30","author":"Tabatabaee","year":"2015","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2016.12.049_bib21","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.bone.2011.07.032","article-title":"Autologous bone marrow cell implantation in the treatment of non-traumatic osteonecrosis of the femoral head: five year follow-up of a prospective controlled study","volume":"49","author":"Gangji","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.arth.2016.12.049_bib22","doi-asserted-by":"crossref","first-page":"e61","DOI":"10.1038\/emm.2013.128","article-title":"Stem cell implantation for osteonecrosis of the femoral head","volume":"45","author":"Lim","year":"2013","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.arth.2016.12.049_bib23","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00402-012-1623-3","article-title":"Core decompression and implantation of bone marrow mononuclear cells with porous hydroxylapatite composite filler for the treatment of osteonecrosis of the femoral head","volume":"133","author":"Liu","year":"2013","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/j.arth.2016.12.049_bib24","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1302\/0301-620X.92B3.22483","article-title":"Bone-marrow-derived mononuclear cells with a porous hydroxyapatite scaffold for the treatment of osteonecrosis of the femoral head: a preliminary study","volume":"92","author":"Yamasaki","year":"2010","journal-title":"J\u00a0Bone Joint Surg Br"},{"key":"10.1016\/j.arth.2016.12.049_bib25","doi-asserted-by":"crossref","first-page":"6162","DOI":"10.4081\/or.2016.6162","article-title":"Core decompression and autologous bone marrow concentrate for treatment of femoral head osteonecrosis: a randomized prospective study","volume":"8","author":"Pepke","year":"2016","journal-title":"Orthop Rev (Pavia)"},{"key":"10.1016\/j.arth.2016.12.049_bib26","first-page":"41","article-title":"A\u00a0new international classification of osteonecrosis of the ARCO committee on terminology and classification","volume":"4","author":"Gardeniers","year":"1992","journal-title":"ARCO Newsl"},{"key":"10.1016\/j.arth.2016.12.049_bib27","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00264-007-0320-2","article-title":"Avascular necrosis of the femoral head: inter- and intraobserver variations of Ficat and ARCO classifications","volume":"32","author":"Schmitt-Sody","year":"2008","journal-title":"Int Orthop"},{"key":"10.1016\/j.arth.2016.12.049_bib28","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1302\/0301-620X.67B1.3155745","article-title":"Idiopathic bone necrosis of the femoral head. Early diagnosis and treatment","volume":"67","author":"Ficat","year":"1985","journal-title":"J\u00a0Bone Joint Surg Br"},{"key":"10.1016\/j.arth.2016.12.049_bib29","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3109\/17453674.2015.1077418","article-title":"The role of \u201ccell therapy\u201d in osteonecrosis of the femoral head","volume":"87","author":"Papakostidis","year":"2015","journal-title":"Acta Orthop"},{"key":"10.1016\/j.arth.2016.12.049_bib30","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/00003086-199603000-00020","article-title":"Core decompression versus nonoperative management for osteonecrosis of the hip","author":"Mont","year":"1996","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2016.12.049_bib31","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/1471-2474-15-156","article-title":"Stem cell therapy for the treatment of early stage avascular necrosis of the femoral head: a systematic review","volume":"15","author":"Lau","year":"2014","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.arth.2016.12.049_bib32","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.2106\/JBJS.15.01495","article-title":"Intra-articular cellular therapy for osteoarthritis","volume":"98","author":"Chahla","year":"2016","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2016.12.049_bib33","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1097\/BOT.0000000000000459","article-title":"Stem cell therapies in orthopaedic trauma","volume":"29","author":"Marcucio","year":"2015","journal-title":"J\u00a0Orthop Trauma"},{"key":"10.1016\/j.arth.2016.12.049_bib34","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.4081\/or.2009.e32","article-title":"Safety of autologous bone marrow aspiration concentrate transplantation: initial experiences in 101 patients","volume":"1","author":"Hendrich","year":"2009","journal-title":"Orthop Rev (Pavia)"},{"key":"10.1016\/j.arth.2016.12.049_bib35","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.2106\/JBJS.M.00261","article-title":"Cancer risk is not increased in patients treated for orthopaedic diseases with autologous bone marrow cell concentrate","volume":"95-A","author":"Hernigou","year":"2013","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2016.12.049_bib36","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.joca.2013.06.025","article-title":"Safety of intra-articular cell-therapy with culture-expanded stem cells in humans: a systematic literature review","volume":"21","author":"Peeters","year":"2013","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.arth.2016.12.049_bib37","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1186\/s12891-016-1199-0","article-title":"Multiple drilling combined with simvastatin versus multiple drilling alone for the treatment of avascular osteonecrosis of the femoral head: 3-year follow-up study","volume":"17","author":"Yin","year":"2016","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.arth.2016.12.049_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00402-012-1627-z","article-title":"Vascularized fibular grafts in patients with avascular necrosis of femoral head: a systematic review and meta-analysis","volume":"133","author":"Fang","year":"2013","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/j.arth.2016.12.049_bib39","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00264-012-1773-5","article-title":"Vascularised greater trochanter bone graft, combined free iliac flap and impaction bone grafting for osteonecrosis of the femoral head","volume":"37","author":"Zeng","year":"2013","journal-title":"Int Orthop"},{"key":"10.1016\/j.arth.2016.12.049_bib40","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1615\/CritRevBiomedEng.v40.i5.10","article-title":"Bone tissue engineering: recent advances and challenges","volume":"40","author":"Amini","year":"2012","journal-title":"Crit Rev Biomed Eng"},{"key":"10.1016\/j.arth.2016.12.049_bib41","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1582-4934.2010.01224.x","article-title":"Bone regeneration and stem cells","volume":"15","author":"Arvidson","year":"2011","journal-title":"J\u00a0Cell Mol Med"},{"key":"10.1016\/j.arth.2016.12.049_bib42","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/jor.1100090504","article-title":"Mesenchymal stem cells","volume":"9","author":"Caplan","year":"1991","journal-title":"J\u00a0Orthop Res"},{"key":"10.1016\/j.arth.2016.12.049_bib43","doi-asserted-by":"crossref","first-page":"S257","DOI":"10.1097\/00003086-199810001-00026","article-title":"Clinical use of marrow osteoprogenitor cells to stimulate osteogenesis","author":"Connolly","year":"1998","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2016.12.049_bib44","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"10.1016\/j.arth.2016.12.049_bib45","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1741-7015-9-66","article-title":"Bone regeneration: current concepts and future directions","volume":"9","author":"Dimitriou","year":"2011","journal-title":"BMC Med"},{"key":"10.1016\/j.arth.2016.12.049_bib46","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S0020-1383(13)70002-0","article-title":"Bone regeneration strategies: current trends but what the future holds?","volume":"44","author":"Giannoudis","year":"2013","journal-title":"Injury"},{"key":"10.1016\/j.arth.2016.12.049_bib47","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/nrendo.2014.234","article-title":"Stromal cells and stem cells in clinical bone regeneration","volume":"11","author":"Grayson","year":"2015","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.arth.2016.12.049_bib48","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.2106\/00004623-200407000-00029","article-title":"Engineering principles of clinical cell-based tissue engineering","volume":"86-A","author":"Muschler","year":"2004","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2016.12.049_bib49","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/00003086-200202000-00008","article-title":"Connective tissue progenitors: practical concepts for clinical applications","volume":"1","author":"Muschler","year":"2002","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2016.12.049_bib50","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1155\/S1110724303209165","article-title":"Practical modeling concepts for connective tissue stem cell and progenitor compartment kinetics","volume":"2003","author":"Muschler","year":"2003","journal-title":"J\u00a0Biomed Biotechnol"},{"key":"10.1016\/j.arth.2016.12.049_bib51","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0736-0266(00)00010-3","article-title":"Age- and gender-related changes in the cellularity of human bone marrow and the prevalence of osteoblastic progenitors","volume":"19","author":"Muschler","year":"2001","journal-title":"J\u00a0Orthop Res"},{"issue":"Suppl 1","key":"10.1016\/j.arth.2016.12.049_bib52","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2106\/JBJS.G.01572","article-title":"Cellular strategies for enhancement of fracture repair","volume":"90","author":"Patterson","year":"2008","journal-title":"J\u00a0Bone Joint Surg Am"}],"container-title":["The Journal of Arthroplasty"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540316309354?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540316309354?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T08:33:00Z","timestamp":1568709180000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883540316309354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["S0883540316309354"],"URL":"https:\/\/doi.org\/10.1016\/j.arth.2016.12.049","relation":{},"ISSN":["0883-5403"],"issn-type":[{"value":"0883-5403","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evidence for the Use of Cell-Based Therapy for the Treatment of Osteonecrosis of the Femoral Head: A Systematic Review of the Literature","name":"articletitle","label":"Article Title"},{"value":"The Journal of Arthroplasty","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arth.2016.12.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}