{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T09:33:21Z","timestamp":1772357601746,"version":"3.50.1"},"reference-count":13,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","arthroplastyjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Arthroplasty"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.arth.2018.01.007","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T20:28:32Z","timestamp":1516134512000},"page":"1896-1898","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["The Alpha-Defensin Test for Diagnosing Periprosthetic Joint Infection in the Setting of an Adverse Local Tissue Reaction Secondary to a Failed Metal-on-Metal Bearing or Corrosion at the Head-Neck Junction"],"prefix":"10.1016","volume":"33","author":[{"given":"Kamil T.","family":"Okroj","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyler E.","family":"Calkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erdan","family":"Kayupov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael M.","family":"Kheir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua S.","family":"Bingham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher P.","family":"Beauchamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javad","family":"Parvizi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig J.","family":"Della Valle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.arth.2018.01.007_bib1","first-page":"145","article-title":"Infection or metal hypersensitivity? The diagnostic challenge of failure in metal-on-metal bearings","volume":"77","author":"Galbraith","year":"2011","journal-title":"Acta Orthop Belgica"},{"key":"10.1016\/j.arth.2018.01.007_bib2","first-page":"59","article-title":"Concomitant infection and local metal reaction in patients undergoing revision of metal on metal total hip arthroplasty","volume":"31","author":"Judd","year":"2011","journal-title":"Iowa Orthop J"},{"key":"10.1016\/j.arth.2018.01.007_bib3","doi-asserted-by":"crossref","first-page":"443","DOI":"10.2106\/JBJS.H.00603","article-title":"Failure of metal-on-metal total hip arthroplasty mimicking hip infection. A report of two cases","volume":"91","author":"Mikhael","year":"2009","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2018.01.007_bib4","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1007\/s11999-014-3902-5","article-title":"Do serologic and synovial tests help diagnose infection in revision hip arthroplasty with metal-on-metal bearings or corrosion?","volume":"473","author":"Yi","year":"2015","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2018.01.007_bib5","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.arth.2012.11.006","article-title":"Utility of synovial fluid aspirations in failed metal-on-metal total hip arthroplasty","volume":"28","author":"Wyles","year":"2013","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2018.01.007_bib6","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1007\/s11999-014-3900-7","article-title":"The alpha defensin-1 biomarker assay can be used to evaluate the potentially infected total joint arthroplasty","volume":"472","author":"Bingham","year":"2014","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2018.01.007_bib7","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1007\/s11999-010-1298-4","article-title":"Synovial fluid biomarkers for periprosthetic infection","volume":"468","author":"Deirmengian","year":"2010","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2018.01.007_bib8","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s11999-014-3722-7","article-title":"The alpha-defensin test for periprosthetic joint infection outperforms the leukocyte esterase test strip","volume":"473","author":"Deirmengian","year":"2015","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2018.01.007_bib9","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1007\/s11999-014-3543-8","article-title":"Diagnosing periprosthetic joint infection: has the era of the biomarker arrived?","volume":"472","author":"Deirmengian","year":"2014","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2018.01.007_bib10","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.2106\/JBJS.M.01316","article-title":"Combined measurement of synovial fluid alpha-defensin and C-reactive protein levels: highly accurate for diagnosing periprosthetic joint infection","volume":"96","author":"Deirmengian","year":"2014","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2018.01.007_bib11","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1007\/s11999-015-4152-x","article-title":"The alpha-defensin test for periprosthetic joint infection responds to a wide spectrum of organisms","volume":"473","author":"Deirmengian","year":"2015","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2018.01.007_bib12","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.arth.2015.09.035","article-title":"Alpha-defensin accuracy to diagnose periprosthetic joint infection-best available test?","volume":"31","author":"Frangiamore","year":"2015","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2018.01.007_bib13","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1007\/s11999-016-4726-2","article-title":"The alpha-defensin test for periprosthetic joint infections is not affected by prior antibiotic administration","volume":"474","author":"Shahi","year":"2016","journal-title":"Clin Orthop Relat Res"}],"container-title":["The Journal of Arthroplasty"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540318300159?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540318300159?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T18:27:53Z","timestamp":1542047273000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883540318300159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S0883540318300159"],"URL":"https:\/\/doi.org\/10.1016\/j.arth.2018.01.007","relation":{},"ISSN":["0883-5403"],"issn-type":[{"value":"0883-5403","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Alpha-Defensin Test for Diagnosing Periprosthetic Joint Infection in the Setting of an Adverse Local Tissue Reaction Secondary to a Failed Metal-on-Metal Bearing or Corrosion at the Head-Neck Junction","name":"articletitle","label":"Article Title"},{"value":"The Journal of Arthroplasty","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arth.2018.01.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}