{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T09:52:02Z","timestamp":1784627522079,"version":"3.55.0"},"reference-count":17,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","arthroplastyjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Arthroplasty"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.arth.2018.06.026","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T02:39:02Z","timestamp":1530153542000},"page":"3537-3540","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Synovial Fluid Alpha-Defensin Is an Adjunctive Tool in the Equivocal Diagnosis of Periprosthetic Joint Infection"],"prefix":"10.1016","volume":"33","author":[{"given":"Mick P.","family":"Kelly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Darrith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles P.","family":"Hannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Nam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Maxwell","family":"Courtney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig J.","family":"Della Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arth.2018.06.026_bib1","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.2106\/JBJS.L.00789","article-title":"Periprosthetic joint infection increases the risk of one-year mortality","volume":"95","author":"Zmistowski","year":"2013","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2018.06.026_bib2","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/j.arth.2013.07.024","article-title":"Why are total knee arthroplasties failing today\u2013has anything changed after 10 years?","volume":"29","author":"Sharkey","year":"2014","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2018.06.026_bib3","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1016\/j.arth.2017.02.046","article-title":"Current epidemiology of revision total hip arthroplasty in the United States: national inpatient sample 2009 to 2013","volume":"32","author":"Gwam","year":"2017","journal-title":"J\u00a0Arthroplasty"},{"issue":"8 Suppl","key":"10.1016\/j.arth.2018.06.026_bib4","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.arth.2012.02.022","article-title":"Economic burden of periprosthetic joint infection in the United States","volume":"27","author":"Kurtz","year":"2012","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2018.06.026_bib5","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1172\/JCI112120","article-title":"Defensins. Natural peptide antibiotics of human neutrophils","volume":"76","author":"Ganz","year":"1985","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.arth.2018.06.026_bib6","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.2106\/JBJS.17.00123","article-title":"Synovial fluid biomarkers for the diagnosis of periprosthetic joint infection: a systematic review and meta-analysis","volume":"99","author":"Lee","year":"2017","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2018.06.026_bib7","doi-asserted-by":"crossref","first-page":"763","DOI":"10.5435\/JAAOS-D-16-00548","article-title":"The diagnostic utility of synovial fluid markers in periprosthetic joint infection: a systematic review and meta-analysis","volume":"25","author":"Saleh","year":"2017","journal-title":"J\u00a0Am Acad Orthop Surg"},{"key":"10.1016\/j.arth.2018.06.026_bib8","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.arth.2014.03.009","article-title":"Definition of periprosthetic joint infection","volume":"29","author":"Parvizi","year":"2014","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2018.06.026_bib9","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.2106\/JBJS.M.01316","article-title":"Combined measurement of synovial fluid alpha-defensin and C-reactive protein levels: highly accurate for diagnosing periprosthetic joint infection","volume":"96","author":"Deirmengian","year":"2014","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2018.06.026_bib10","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1007\/s11999-014-3900-7","article-title":"The alpha defensin-1 biomarker assay can be used to evaluate the potentially infected total joint arthroplasty","volume":"472","author":"Bingham","year":"2014","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2018.06.026_bib11","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s11999-014-3722-7","article-title":"The alpha-defensin test for periprosthetic joint infection outperforms the leukocyte esterase test strip","volume":"473","author":"Deirmengian","year":"2015","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2018.06.026_bib12","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1302\/0301-620X.99B9.BJJ-2016-1345.R2","article-title":"Diagnosis of prosthetic joint infection with alpha-defensin using a lateral flow device: a multicentre study","volume":"99-b","author":"Berger","year":"2017","journal-title":"Bone Joint J"},{"key":"10.1016\/j.arth.2018.06.026_bib13","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1007\/s11999-016-4906-0","article-title":"How reliable is the alpha-defensin immunoassay test for diagnosing periprosthetic joint infection? A prospective study","volume":"475","author":"Bonanzinga","year":"2017","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2018.06.026_bib14","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1007\/s11999-015-4142-z","article-title":"Premature therapeutic antimicrobial treatments can compromise the diagnosis of late periprosthetic joint infection","volume":"473","author":"Shahi","year":"2015","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2018.06.026_bib15","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1007\/s11999-016-4726-2","article-title":"The alpha-defensin test for periprosthetic joint infections is not affected by prior antibiotic administration","volume":"474","author":"Shahi","year":"2016","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2018.06.026_bib16","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1093\/rheumatology\/ket147","article-title":"The role of alpha-defensin-1 and related signal transduction mechanisms in the production of IL-6, IL-8 and MMPs in rheumatoid fibroblast-like synoviocytes","volume":"52","author":"Ahn","year":"2013","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.arth.2018.06.026_bib17","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00590-017-1942-8","article-title":"False-positive synovial fluid alpha-defensin test in a patient with acute gout affecting a prosthetic knee","volume":"27","author":"Partridge","year":"2017","journal-title":"Eur J Orthop Surg Traumatol"}],"container-title":["The Journal of Arthroplasty"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540318305965?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540318305965?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T22:22:12Z","timestamp":1539210132000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883540318305965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":17,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["S0883540318305965"],"URL":"https:\/\/doi.org\/10.1016\/j.arth.2018.06.026","relation":{},"ISSN":["0883-5403"],"issn-type":[{"value":"0883-5403","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synovial Fluid Alpha-Defensin Is an Adjunctive Tool in the Equivocal Diagnosis of Periprosthetic Joint Infection","name":"articletitle","label":"Article Title"},{"value":"The Journal of Arthroplasty","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arth.2018.06.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}