{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T16:02:07Z","timestamp":1775318527099,"version":"3.50.1"},"reference-count":174,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","arthroplastyjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Arthroplasty"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.arth.2018.12.001","type":"journal-article","created":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T12:17:40Z","timestamp":1545049060000},"page":"801-813","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"title":["Biologic Therapies for the Treatment of Knee Osteoarthritis"],"prefix":"10.1016","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5651-2625","authenticated-orcid":false,"given":"Ronald E.","family":"Delanois","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer I.","family":"Etcheson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nipun","family":"Sodhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Ralph F.","family":"Henn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0579-3524","authenticated-orcid":false,"given":"Chukwuweike U.","family":"Gwam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole E.","family":"George","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Mont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.arth.2018.12.001_bib1","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.jcyt.2017.07.006","article-title":"Stem cell industry update: 2012 to 2016 reveals accelerated investment, but market capitalization and earnings lag","volume":"19","author":"Ng","year":"2017","journal-title":"Cytotherapy"},{"key":"10.1016\/j.arth.2018.12.001_bib2","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s00423-009-0546-0","article-title":"The possible use of stem cells in regenerative medicine: dream or reality?","volume":"394","author":"Ehnert","year":"2009","journal-title":"Langenbecks Arch Surg"},{"key":"10.1016\/j.arth.2018.12.001_bib3","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.arth.2017.09.038","article-title":"Association between body mass index and thirty-day complications after total knee arthroplasty","volume":"33","author":"George","year":"2018","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2018.12.001_bib4","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1016\/j.arth.2017.12.020","article-title":"What influence does the time of year have on postoperative complications following total knee arthroplasty?","volume":"33","author":"Sodhi","year":"2018","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2018.12.001_bib5","first-page":"22","article-title":"[Obesity: risk factor and predictor of osteoarthritis]","volume":"131","author":"Grazio","year":"2009","journal-title":"Lijec Vjesn"},{"key":"10.1016\/j.arth.2018.12.001_bib6","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.cger.2010.03.001","article-title":"Epidemiology of osteoarthritis","volume":"26","author":"Zhang","year":"2010","journal-title":"Clin Geriatr Med"},{"key":"10.1016\/j.arth.2018.12.001_bib7","first-page":"627","article-title":"Platelet-rich plasma for the treatment of knee osteoarthritis: a review","volume":"30","author":"Piuzzi","year":"2017","journal-title":"J\u00a0Knee Surg"},{"key":"10.1016\/j.arth.2018.12.001_bib8","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1136\/annrheumdis-2017-211396","article-title":"Microarray analysis of bone marrow lesions in osteoarthritis demonstrates upregulation of genes implicated in osteochondral turnover, neurogenesis and inflammation","volume":"76","author":"Kuttapitiya","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.arth.2018.12.001_bib9","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nrrheum.2017.182","article-title":"Native joint-resident mesenchymal stem cells for cartilage repair in osteoarthritis","volume":"13","author":"McGonagle","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.arth.2018.12.001_bib10","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s00264-016-3370-5","article-title":"Correlations between serum adipocytokine concentrations, disease stage, radiological status and total body fat content in the patients with primary knee osteoarthritis","volume":"41","author":"Richter","year":"2017","journal-title":"Int Orthop"},{"key":"10.1016\/j.arth.2018.12.001_bib11","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.ypmed.2007.07.017","article-title":"Physical activity level and health-related quality of life in the general adult population: a systematic review","volume":"45","author":"Bize","year":"2007","journal-title":"Prev Med"},{"key":"10.1016\/j.arth.2018.12.001_bib12","series-title":"Regulatory considerations for human cells, tissues, and cellular and tissue-based products: minimal manipulation and homologous use. Guidance for Industry and Food and Drug Administration Staff","author":"Fda","year":"2017"},{"key":"10.1016\/j.arth.2018.12.001_bib13","series-title":"Stem cell therapies are still mostly theory, yet clinics are flourishing","year":"2016"},{"key":"10.1016\/j.arth.2018.12.001_bib14","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.stem.2016.06.007","article-title":"Selling stem cells in the USA: assessing the direct-to-consumer industry","volume":"19","author":"Turner","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.arth.2018.12.001_bib15","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/494166a","article-title":"Stem cells in Texas: cowboy culture","volume":"494","author":"Cyranoski","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.arth.2018.12.001_bib16","series-title":"FDA moves to crack down on unproven stem cell therapies","year":"2016"},{"key":"10.1016\/j.arth.2018.12.001_bib17","doi-asserted-by":"crossref","first-page":"eaag0426","DOI":"10.1126\/scitranslmed.aag0426","article-title":"Marketing of unproven stem cell-based interventions: a call to action","volume":"9","author":"Sipp","year":"2017","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.arth.2018.12.001_bib18","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1002\/stem.1634","article-title":"Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial","volume":"32","author":"Jo","year":"2014","journal-title":"Stem Cells"},{"key":"10.1016\/j.arth.2018.12.001_bib19","first-page":"117","article-title":"Mesenchymal stem cell therapy for osteoarthritis: current perspectives","volume":"8","author":"Wyles","year":"2015","journal-title":"Stem Cells Cloning"},{"key":"10.1016\/j.arth.2018.12.001_bib20","series-title":"AAOS bulletin","year":"2005"},{"key":"10.1016\/j.arth.2018.12.001_bib21","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1177\/0363546515582027","article-title":"Platelet-rich plasma intra-articular knee injections show no superiority versus viscosupplementation","volume":"43","author":"Filardo","year":"2015","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.arth.2018.12.001_bib22","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1177\/0363546515580787","article-title":"Effect of leukocyte concentration on the efficacy of platelet-rich plasma in the treatment of knee osteoarthritis","volume":"44","author":"Riboh","year":"2016","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.arth.2018.12.001_bib23","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1177\/0363546515570463","article-title":"Platelet-rich plasma increases anti-inflammatory markers in a human coculture model for osteoarthritis","volume":"43","author":"Osterman","year":"2015","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.arth.2018.12.001_bib24","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.pmrj.2015.02.003","article-title":"Use of platelet-rich plasma in intra-articular knee injections for osteoarthritis: a systematic review","volume":"7","author":"Lai","year":"2015","journal-title":"PM R"},{"key":"10.1016\/j.arth.2018.12.001_bib25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.12998\/wjcc.v3.i2.89","article-title":"State-of-the-art management of knee osteoarthritis","volume":"3","author":"Fibel","year":"2015","journal-title":"World J Clin Cases"},{"key":"10.1016\/j.arth.2018.12.001_bib26","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.3760\/cma.j.issn.0366-6999.20141652","article-title":"Role of platelet-rich plasma in articular cartilage lesions","volume":"127","author":"Li","year":"2014","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.arth.2018.12.001_bib27","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1136\/bjsports-2014-094036","article-title":"Efficacy of platelet-rich plasma injections in osteoarthritis of the knee: a systematic review and meta-analysis","volume":"49","author":"Laudy","year":"2015","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.arth.2018.12.001_bib28","doi-asserted-by":"crossref","first-page":"5405","DOI":"10.4081\/or.2014.5405","article-title":"Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial","volume":"6","author":"Rayegani","year":"2014","journal-title":"Orthop Rev (Pavia)"},{"key":"10.1016\/j.arth.2018.12.001_bib29","doi-asserted-by":"crossref","first-page":"351","DOI":"10.5312\/wjo.v5.i3.351","article-title":"Intraarticular injections (corticosteroid, hyaluronic acid, platelet rich plasma) for the knee osteoarthritis","volume":"5","author":"Ayhan","year":"2014","journal-title":"World J Orthop"},{"key":"10.1016\/j.arth.2018.12.001_bib30","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s12178-014-9229-8","article-title":"Update on biological therapies for knee injuries: osteoarthritis","volume":"7","author":"Pintan","year":"2014","journal-title":"Curr Rev Musculoskelet Med"},{"key":"10.1016\/j.arth.2018.12.001_bib31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3810\/psm.2014.05.2055","article-title":"The effects of platelet-rich plasma in the treatment of large-joint osteoarthritis: a systematic review","volume":"42","author":"Tietze","year":"2014","journal-title":"Phys Sportsmed"},{"key":"10.1016\/j.arth.2018.12.001_bib32","doi-asserted-by":"crossref","first-page":"e97293","DOI":"10.1371\/journal.pone.0097293","article-title":"A\u00a0comparison between platelet-rich plasma (PRP) and hyaluronate acid on the healing of cartilage defects","volume":"9","author":"Liu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.arth.2018.12.001_bib33","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1517\/14712598.2014.889677","article-title":"Knee osteoarthritis: hyaluronic acid, platelet-rich plasma or both in association?","volume":"14","author":"Andia","year":"2014","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.arth.2018.12.001_bib34","first-page":"165967","article-title":"The effect of platelet-rich plasma on pain, function, and quality of life of patients with knee osteoarthritis","volume":"2013","author":"Raeissadat","year":"2013","journal-title":"Pain Res Treat"},{"key":"10.1016\/j.arth.2018.12.001_bib35","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.apmr.2013.11.006","article-title":"Comparative effectiveness of platelet-rich plasma injections for treating knee joint cartilage degenerative pathology: a systematic review and meta-analysis","volume":"95","author":"Chang","year":"2014","journal-title":"Arch Phys Med Rehabil"},{"key":"10.1016\/j.arth.2018.12.001_bib36","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1016\/j.arthro.2013.09.006","article-title":"The efficacy of platelet-rich plasma in the treatment of symptomatic knee osteoarthritis: a systematic review with quantitative synthesis","volume":"29","author":"Khoshbin","year":"2013","journal-title":"Arthroscopy"},{"key":"10.1016\/j.arth.2018.12.001_bib37","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1007\/s00167-013-2743-1","article-title":"Platelet-rich plasma: why intra-articular? A systematic review of preclinical studies and clinical evidence on PRP for joint degeneration","volume":"23","author":"Filardo","year":"2015","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.arth.2018.12.001_bib38","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1177\/0363546515624678","article-title":"Intra-articular autologous conditioned plasma injections provide safe and efficacious treatment for knee osteoarthritis: an FDA-sanctioned, randomized, double-blind, placebo-controlled clinical trial","volume":"44","author":"Smith","year":"2016","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.arth.2018.12.001_bib39","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/BOR.0b013e32835f69b4","article-title":"New treatments for osteoarthritis","volume":"25","author":"Smelter","year":"2013","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.arth.2018.12.001_bib40","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00590-012-1037-5","article-title":"Platelet-rich plasma (PRP) injections as an effective treatment for early osteoarthritis","volume":"23","author":"Jang","year":"2013","journal-title":"Eur J Orthop Surg Traumatol"},{"key":"10.1016\/j.arth.2018.12.001_bib41","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/JSM.0b013e31827c3846","article-title":"Clinical and MRI outcomes after platelet-rich plasma treatment for knee osteoarthritis","volume":"23","author":"Halpern","year":"2013","journal-title":"Clin J Sport Med"},{"key":"10.1016\/j.arth.2018.12.001_bib42","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.reuma.2012.05.011","article-title":"Platelet rich plasma. A new treatment tool for the rheumatologist?","volume":"9","author":"De La Mata","year":"2013","journal-title":"Reumatol Clin"},{"key":"10.1016\/j.arth.2018.12.001_bib43","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1007\/s00167-012-2043-1","article-title":"The type of platelet-rich plasma may influence the safety of the approach","volume":"22","author":"Anitua","year":"2014","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.arth.2018.12.001_bib44","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s40814-018-0288-2","article-title":"Platelet-rich plasma (PRP) therapy for knee arthritis: a feasibility study in primary care","volume":"4","author":"Glynn","year":"2018","journal-title":"Pilot Feasibility Stud"},{"key":"10.1016\/j.arth.2018.12.001_bib45","first-page":"43","article-title":"Systematic clinical evidence review of NASHA (Durolane hyaluronic acid) for the treatment of knee osteoarthritis","volume":"10","author":"Leighton","year":"2018","journal-title":"Open Access Rheumatol Res Rev"},{"key":"10.1016\/j.arth.2018.12.001_bib46","first-page":"918","article-title":"[Effect of intra-articular injection of platelet-rich plasma on interleukin-17 expression in synovial fluid and venous plasma of knee osteoarthritis patients]","volume":"31","author":"Zhang","year":"2017","journal-title":"Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi"},{"key":"10.1016\/j.arth.2018.12.001_bib47","first-page":"3096","article-title":"Platelet-rich plasma shows beneficial effects for patients with knee osteoarthritis by suppressing inflammatory factors","volume":"15","author":"Huang","year":"2018","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.arth.2018.12.001_bib48","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2147\/DDDT.S156724","article-title":"Intra-articular platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis","volume":"12","author":"Zhang","year":"2018","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.arth.2018.12.001_bib49","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1007\/s00167-018-4883-9","article-title":"Intra-articular injections of expanded mesenchymal stem cells with and without addition of platelet-rich plasma are safe and effective for knee osteoarthritis","volume":"26","author":"Bastos","year":"2018","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.arth.2018.12.001_bib50","first-page":"253","article-title":"Conservative management of MRI-confirmed knee osteoarthritis with instrument-assisted soft-tissue mobilization, joint manipulation, and platelet-rich plasma","volume":"61","author":"Karmali","year":"2017","journal-title":"J\u00a0Can Chiropr Assoc"},{"key":"10.1016\/j.arth.2018.12.001_bib51","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/j.arthro.2017.11.035","article-title":"Growth factors levels determine efficacy of platelets rich plasma injection in knee osteoarthritis: a randomized double blind noninferiority trial compared with viscosupplementation","volume":"34","author":"Louis","year":"2018","journal-title":"Arthroscopy"},{"key":"10.1016\/j.arth.2018.12.001_bib52","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2147\/CIA.S147757","article-title":"The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis","volume":"13","author":"Rahimzadeh","year":"2018","journal-title":"Clin Interv Aging"},{"key":"10.1016\/j.arth.2018.12.001_bib53","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1177\/0363546517750635","article-title":"Intra-articular injections of platelet-rich plasma releasate reduce pain and synovial inflammation in a mouse model of osteoarthritis","volume":"46","author":"Khatab","year":"2018","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.arth.2018.12.001_bib54","doi-asserted-by":"crossref","first-page":"e2065","DOI":"10.1016\/j.eats.2017.08.006","article-title":"Meniscal repair with fibrin clot augmentation","volume":"6","author":"Chahla","year":"2017","journal-title":"Arthrosc Tech"},{"key":"10.1016\/j.arth.2018.12.001_bib55","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1111\/1756-185X.13233","article-title":"Intra-articular platelet-rich plasma injections for knee osteoarthritis: an overview of systematic reviews and risk of bias considerations","volume":"20","author":"Xing","year":"2017","journal-title":"Int J Rheum Dis"},{"key":"10.1016\/j.arth.2018.12.001_bib56","doi-asserted-by":"crossref","first-page":"142","DOI":"10.5606\/ehc.2017.55186","article-title":"Does leukocyte-poor or leukocyte-rich platelet-rich plasma applied with biopolymers have superiority to conventional platelet-rich plasma applications on chondrocyte proliferation?","volume":"28","author":"Yasar Sirin","year":"2017","journal-title":"Eklem Hastalik Cerrahisi"},{"key":"10.1016\/j.arth.2018.12.001_bib57","doi-asserted-by":"crossref","first-page":"15733","DOI":"10.1038\/s41598-017-16134-6","article-title":"Cryopreservation of human mesenchymal stem cells in an allogeneic bioscaffold based on platelet rich plasma and synovial fluid","volume":"7","author":"Gurruchaga","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.arth.2018.12.001_bib58","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1055\/s-0037-1601405","article-title":"Single platelet-rich plasma injection for early stage of osteoarthritis of the knee","volume":"5","author":"Martini","year":"2017","journal-title":"Joints"},{"key":"10.1016\/j.arth.2018.12.001_bib59","doi-asserted-by":"crossref","first-page":"426","DOI":"10.32098\/mltj.03.2017.04","article-title":"The effect of intra-articular allogenic platelet rich plasma in Dunkin-Hartley guinea pig model of knee osteoarthritis","volume":"7","author":"Kanwat","year":"2017","journal-title":"Muscles Ligaments Tendons J"},{"key":"10.1016\/j.arth.2018.12.001_bib60","doi-asserted-by":"crossref","DOI":"10.1177\/1179544117733452","article-title":"Efficacy of intra-articular injection of a newly developed plasma rich in growth factor (PRGF) versus hyaluronic acid on pain and function of patients with knee osteoarthritis: a single-blinded randomized clinical trial","volume":"10","author":"Raeissadat","year":"2017","journal-title":"Clin Med Insights Arthritis Musculoskelet Disord"},{"key":"10.1016\/j.arth.2018.12.001_bib61","doi-asserted-by":"crossref","first-page":"e41719","DOI":"10.5812\/aapm.41719","article-title":"Adding intra-articular growth hormone to platelet rich plasma under ultrasound guidance in knee osteoarthritis: a comparative double-blind clinical trial","volume":"6","author":"Rahimzadeh","year":"2016","journal-title":"Anesthesiol Pain Med"},{"key":"10.1016\/j.arth.2018.12.001_bib62","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.surge.2017.08.004","article-title":"A\u00a0systematic review of the effects of platelet rich plasma on outcomes for patients with knee osteoarthritis and following total knee arthroplasty","volume":"16","author":"Muchedzi","year":"2018","journal-title":"Surgeon"},{"key":"10.1016\/j.arth.2018.12.001_bib63","doi-asserted-by":"crossref","first-page":"7538604","DOI":"10.1155\/2017\/7538604","article-title":"Responders to platelet-rich plasma in osteoarthritis: a technical analysis","volume":"2017","author":"Milants","year":"2017","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.arth.2018.12.001_bib64","first-page":"686","article-title":"Comparison of platelet-rich plasma, stromal vascular fraction (SVF), or SVF with an injectable PLGA nanofiber scaffold for the treatment of osteochondral injury in dogs","volume":"31","author":"Franklin","year":"2018","journal-title":"J\u00a0Knee Surg"},{"key":"10.1016\/j.arth.2018.12.001_bib65","doi-asserted-by":"crossref","first-page":"108","DOI":"10.2174\/1573397113666170829155149","article-title":"Current treatment options for osteoarthritis","volume":"14","author":"Hermann","year":"2018","journal-title":"Curr Rheumatol Rev"},{"key":"10.1016\/j.arth.2018.12.001_bib66","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1080\/17453674.2017.1368899","article-title":"Biological treatment of the knee with platelet-rich plasma or bone marrow aspirate concentrates","volume":"88","author":"Moatshe","year":"2017","journal-title":"Acta Orthop"},{"key":"10.1016\/j.arth.2018.12.001_bib67","series-title":"Treatment of osteoarthritis of the knee: an update review","author":"Newberry","year":"2017"},{"key":"10.1016\/j.arth.2018.12.001_bib68","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1177\/0269215517724193","article-title":"Treatment of knee osteoarthritis: platelet-derived growth factors vs. hyaluronic acid. A randomized controlled trial","volume":"32","author":"Lisi","year":"2018","journal-title":"Clin Rehabil"},{"key":"10.1016\/j.arth.2018.12.001_bib69","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1080\/00913847.2017.1357421","article-title":"Biologic injections for osteoarthritis and articular cartilage damage: can we modify disease?","volume":"45","author":"Shi","year":"2017","journal-title":"Phys Sportsmed"},{"key":"10.1016\/j.arth.2018.12.001_bib70","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s12967-017-1242-4","article-title":"Intra-articular injection in the knee of adipose derived stromal cells (stromal vascular fraction) and platelet rich plasma for osteoarthritis","volume":"15","author":"Bansal","year":"2017","journal-title":"J\u00a0Transl Med"},{"key":"10.1016\/j.arth.2018.12.001_bib71","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1080\/14740338.2017.1344211","article-title":"The safety of intra-articular injections for the treatment of knee osteoarthritis: a critical narrative review","volume":"16","author":"Nguyen","year":"2017","journal-title":"Expert Opin Drug Saf"},{"key":"10.1016\/j.arth.2018.12.001_bib72","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1302\/2058-5241.2.160004","article-title":"Platelet-rich plasma (PRP) for knee disorders","volume":"2","author":"Shahid","year":"2017","journal-title":"EFORT Open Rev"},{"key":"10.1016\/j.arth.2018.12.001_bib73","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1589\/jpts.29.896","article-title":"Effect of platelet concentration on clinical improvement in treatment of early stage-knee osteoarthritis with platelet-rich plasma concentrations","volume":"29","author":"Dernek","year":"2017","journal-title":"J\u00a0Phys Ther Sci"},{"key":"10.1016\/j.arth.2018.12.001_bib74","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ijsu.2017.04.067","article-title":"Short-term clinical results of intra-articular PRP injections for early osteoarthritis of the knee","volume":"42","author":"Huang","year":"2017","journal-title":"Int J Surg"},{"key":"10.1016\/j.arth.2018.12.001_bib75","doi-asserted-by":"crossref","first-page":"35","DOI":"10.5704\/MOJ.1607.007","article-title":"Intra-articular hyaluronic acid (HA) and platelet rich plasma (PRP) injection versus hyaluronic acid (HA) injection alone in patients with grade III and IV knee osteoarthritis (OA): a retrospective study on functional outcome","volume":"10","author":"Saturveithan","year":"2016","journal-title":"Malaysian Orthop J"},{"key":"10.1016\/j.arth.2018.12.001_bib76","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.exger.2017.04.004","article-title":"The influence of platelet rich plasma on synovial fluid volumes, protein concentrations, and severity of pain in patients with knee osteoarthritis","volume":"93","author":"Chen","year":"2017","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.arth.2018.12.001_bib77","doi-asserted-by":"crossref","first-page":"e201","DOI":"10.1016\/j.eats.2016.09.024","article-title":"Microdrilling surgery augmented with intra-articular bone marrow aspirate concentrate, platelet-rich plasma, and hyaluronic acid: a technique for cartilage repair in the knee","volume":"6","author":"Broyles","year":"2017","journal-title":"Arthrosc Tech"},{"key":"10.1016\/j.arth.2018.12.001_bib78","doi-asserted-by":"crossref","first-page":"16","DOI":"10.2174\/1874312901711010016","article-title":"Use of saline as a placebo in intra-articular injections in osteoarthritis: potential contributions to nociceptive pain relief","volume":"11","author":"Bar-Or","year":"2017","journal-title":"Open Rheumatol J"},{"key":"10.1016\/j.arth.2018.12.001_bib79","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s11926-017-0652-x","article-title":"Platelet-rich plasma for the management of hip and knee osteoarthritis","volume":"19","author":"Bennell","year":"2017","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.arth.2018.12.001_bib80","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1051\/sicotj\/2017004","article-title":"PRP in OA knee\u2014update, current confusions and future options","volume":"3","author":"Dhillon","year":"2017","journal-title":"SICOT J"},{"key":"10.1016\/j.arth.2018.12.001_bib81","doi-asserted-by":"crossref","DOI":"10.1177\/2325967116689386","article-title":"Platelet-rich plasma injections for advanced knee osteoarthritis: a prospective, randomized, double-blinded clinical trial","volume":"5","author":"Joshi Jubert","year":"2017","journal-title":"Orthop J Sport Med"},{"key":"10.1016\/j.arth.2018.12.001_bib82","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1053\/j.jfas.2016.11.015","article-title":"Conservative treatment of ankle osteoarthritis: can platelet-rich plasma effectively postpone surgery?","volume":"56","author":"Repetto","year":"2017","journal-title":"J\u00a0Foot Ankle Surg"},{"key":"10.1016\/j.arth.2018.12.001_bib83","article-title":"Intra-articular implantation of mesenchymal stem cells, part 1: a review of the literature for prevention of postmeniscectomy osteoarthritis","volume":"5","author":"Kraeutler","year":"2017","journal-title":"Orthop J Sport Med"},{"key":"10.1016\/j.arth.2018.12.001_bib84","doi-asserted-by":"crossref","first-page":"187","DOI":"10.5966\/sctm.2016-0023","article-title":"Comparative clinical observation of arthroscopic microfracture in the presence and absence of a stromal vascular fraction injection for osteoarthritis","volume":"6","author":"Nguyen","year":"2017","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.arth.2018.12.001_bib85","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1177\/0363546516665809","article-title":"Hyaluronic acid versus platelet-rich plasma: a prospective, double-blind randomized controlled trial comparing clinical outcomes and effects on intra-articular biology for the treatment of knee osteoarthritis","volume":"45","author":"Cole","year":"2017","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.arth.2018.12.001_bib86","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13018-017-0521-3","article-title":"The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials","volume":"12","author":"Shen","year":"2017","journal-title":"J\u00a0Orthop Surg Res"},{"key":"10.1016\/j.arth.2018.12.001_bib87","doi-asserted-by":"crossref","first-page":"69","DOI":"10.46582\/jsrm.1202011","article-title":"Randomized controlled trial comparing hyaluronic acid, platelet-rich plasma and the combination of both in the treatment of mild and moderate osteoarthritis of the knee","volume":"12","author":"Lana","year":"2016","journal-title":"J\u00a0Stem Cells Regen Med"},{"key":"10.1016\/j.arth.2018.12.001_bib88","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jcot.2016.05.002","article-title":"Leukocyte-poor platelet-rich plasma to treat degenerative meniscal tear: a case report","volume":"7","author":"Betancourt","year":"2016","journal-title":"J\u00a0Clin Orthop Trauma"},{"key":"10.1016\/j.arth.2018.12.001_bib89","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.arthro.2016.09.024","article-title":"Efficacy of platelet-rich plasma in the treatment of knee osteoarthritis: a meta-analysis of randomized controlled trials","volume":"33","author":"Dai","year":"2017","journal-title":"Arthroscopy"},{"key":"10.1016\/j.arth.2018.12.001_bib90","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1136\/bjsports-2016-097312","article-title":"Systematic review is the highest level of evidence for knee osteoarthritis injection options, not expert society guidelines","volume":"51","author":"Orchard","year":"2017","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.arth.2018.12.001_bib91","first-page":"290","article-title":"Platelet-rich plasma (PRP) in orthopedic sports medicine","volume":"45","author":"Mlynarek","year":"2016","journal-title":"Am J Orthop (Belle Mead NJ)"},{"key":"10.1016\/j.arth.2018.12.001_bib92","doi-asserted-by":"crossref","first-page":"4868613","DOI":"10.1155\/2016\/4868613","article-title":"Combination of intra-articular and intraosseous injections of platelet rich plasma for severe knee osteoarthritis: a pilot study","volume":"2016","author":"Sanchez","year":"2016","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.arth.2018.12.001_bib93","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1177\/0363546516651822","article-title":"Functional recovery in osteoarthritic chondrocytes through hyaluronic acid and platelet-rich plasma-inhibited infrapatellar fat pad adipocytes","volume":"44","author":"Chen","year":"2016","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.arth.2018.12.001_bib94","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.3390\/ijms17071064","article-title":"Intra-articular injections of platelet-rich plasma versus hyaluronic acid in the treatment of osteoarthritic knee pain: a randomized clinical trial in the context of the Spanish National Health Care System","volume":"17","author":"Monta\u00f1ez-Heredia","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.arth.2018.12.001_bib95","doi-asserted-by":"crossref","first-page":"e0156137","DOI":"10.1371\/journal.pone.0156137","article-title":"Leukocyte-rich platelet-rich plasma injections do not up-modulate intra-articular pro-inflammatory cytokines in the osteoarthritic knee","volume":"11","author":"Mariani","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.arth.2018.12.001_bib96","first-page":"319","article-title":"Is platelet-rich plasma right for your patient?","volume":"65","author":"White","year":"2016","journal-title":"J\u00a0Fam Pract"},{"key":"10.1016\/j.arth.2018.12.001_bib97","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.19082\/2115","article-title":"Efficacy of platelet-rich plasma versus hyaluronic acid for treatment of knee osteoarthritis: a systematic review and meta-analysis","volume":"8","author":"Sadabad","year":"2016","journal-title":"Electron Physician"},{"key":"10.1016\/j.arth.2018.12.001_bib98","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.rehab.2016.02.008","article-title":"Evidence and recommendations for use of intra-articular injections for knee osteoarthritis","volume":"59","author":"Nguyen","year":"2016","journal-title":"Ann Phys Rehabil Med"},{"key":"10.1016\/j.arth.2018.12.001_bib99","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.12659\/MSM.898218","article-title":"Advantages of pure platelet-rich plasma compared with leukocyte- and platelet-rich plasma in treating rabbit knee osteoarthritis","volume":"22","author":"Yin","year":"2016","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.arth.2018.12.001_bib100","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00167-016-4110-5","article-title":"Choice of intra-articular injection in treatment of knee osteoarthritis: platelet-rich plasma, hyaluronic acid or ozone options","volume":"25","author":"Duymus","year":"2017","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.arth.2018.12.001_bib101","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1177\/1759720X16631188","article-title":"Homologous platelet-rich plasma for the treatment of knee osteoarthritis in selected elderly patients: an open-label, uncontrolled, pilot study","volume":"8","author":"Bottegoni","year":"2016","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"10.1016\/j.arth.2018.12.001_bib102","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/00913847.2016.1168272","article-title":"Intra-articular treatment of knee osteoarthritis: from anti-inflammatories to products of regenerative medicine","volume":"44","author":"Richards","year":"2016","journal-title":"Phys Sportsmed"},{"key":"10.1016\/j.arth.2018.12.001_bib103","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1517\/14712598.2016.1157162","article-title":"A\u00a0new strategy to tackle severe knee osteoarthritis: combination of intra-articular and intraosseous injections of Platelet Rich Plasma","volume":"16","author":"Sanchez","year":"2016","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.arth.2018.12.001_bib104","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1136\/bjsports-2015-095512","article-title":"Platelet-rich plasma injection is not more effective than hyaluronic acid to treat knee osteoarthritis when using a random-effects model","volume":"50","author":"Wang","year":"2016","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.arth.2018.12.001_bib105","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12891-016-0920-3","article-title":"Intra-articular injection of photo-activated platelet-rich plasma in patients with knee osteoarthritis: a double-blind, randomized controlled pilot study","volume":"17","author":"Paterson","year":"2016","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.arth.2018.12.001_bib106","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.1589\/jpts.27.3863","article-title":"Effectiveness of platelet-rich plasma in the treatment of moderate knee osteoarthritis: a randomized prospective study","volume":"27","author":"Kavadar","year":"2015","journal-title":"J\u00a0Phys Ther Sci"},{"key":"10.1016\/j.arth.2018.12.001_bib107","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1177\/0363546515620383","article-title":"Ultrasound-guided injection of platelet-rich plasma and hyaluronic acid, separately and in combination, for hip osteoarthritis: a randomized controlled study","volume":"44","author":"Dallari","year":"2016","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.arth.2018.12.001_bib108","first-page":"18807","article-title":"Short term results comparison of intraarticular platelet-rich plasma (prp) and hyaluronic acid (ha) applications in early stage of knee osteoarthritis","volume":"8","author":"Kilincoglu","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"10.1016\/j.arth.2018.12.001_bib109","first-page":"799","article-title":"Management of knee osteoarthritis by combined stromal vascular fraction cell therapy, platelet-rich plasma, and musculoskeletal exercises: a case series","volume":"8","author":"Gibbs","year":"2015","journal-title":"J\u00a0Pain Res"},{"key":"10.1016\/j.arth.2018.12.001_bib110","first-page":"223","article-title":"Treatment of knee osteoarthritis with platelet-rich plasma in comparison with transcutaneous electrical nerve stimulation plus exercise: a randomized clinical trial","volume":"29","author":"Angoorani","year":"2015","journal-title":"Med J Islam Repub Iran"},{"key":"10.1016\/j.arth.2018.12.001_bib111","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.arthro.2015.08.005","article-title":"Efficacy of intra-articular platelet-rich plasma injections in knee osteoarthritis: a systematic review","volume":"32","author":"Meheux","year":"2016","journal-title":"Arthroscopy"},{"key":"10.1016\/j.arth.2018.12.001_bib112","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1007\/s00590-015-1693-3","article-title":"Efficacy and safety profile of a compound composed of platelet-rich plasma and hyaluronic acid in the treatment for knee osteoarthritis (preliminary results)","volume":"25","author":"Abate","year":"2015","journal-title":"Eur J Orthop Surg Traumatol"},{"key":"10.1016\/j.arth.2018.12.001_bib113","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1177\/0363546515599632","article-title":"Comparative matched-pair analysis of the injection versus implantation of mesenchymal stem cells for knee osteoarthritis","volume":"43","author":"Kim","year":"2015","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.arth.2018.12.001_bib114","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1007\/s00167-015-3784-4","article-title":"Short-term outcomes of platelet-rich plasma injection for treatment of osteoarthritis of the knee","volume":"24","author":"Kanchanatawan","year":"2016","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.arth.2018.12.001_bib115","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1007\/s00167-015-3705-6","article-title":"Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis: a randomized, double-blind, placebo-controlled trial","volume":"25","author":"Gormeli","year":"2017","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.arth.2018.12.001_bib116","first-page":"901","article-title":"Effect of single injection of platelet-rich plasma in comparison with corticosteroid on knee osteoarthritis: a double-blind randomized clinical trial","volume":"56","author":"Forogh","year":"2016","journal-title":"J\u00a0Sports Med Phys Fitness"},{"key":"10.1016\/j.arth.2018.12.001_bib117","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1016\/j.arthro.2015.03.030","article-title":"Is local viscosupplementation injection clinically superior to other therapies in the treatment of osteoarthritis of the knee: a systematic review of overlapping meta-analyses","volume":"31","author":"Campbell","year":"2015","journal-title":"Arthroscopy"},{"key":"10.1016\/j.arth.2018.12.001_bib118","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1016\/j.arthro.2015.03.041","article-title":"Does intra-articular platelet-rich plasma injection provide clinically superior outcomes compared with other therapies in the treatment of knee osteoarthritis? A systematic review of overlapping meta-analyses","volume":"31","author":"Campbell","year":"2015","journal-title":"Arthroscopy"},{"key":"10.1016\/j.arth.2018.12.001_bib119","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.tibtech.2008.11.009","article-title":"Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF)","volume":"27","author":"Dohan Ehrenfest","year":"2009","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.arth.2018.12.001_bib120","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1177\/0363546512442334","article-title":"Comparison of the acute inflammatory response of two commercial platelet-rich plasma systems in healthy rabbit tendons","volume":"40","author":"Dragoo","year":"2012","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.arth.2018.12.001_bib121","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1177\/0363546512471299","article-title":"Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: a prospective, double-blind, randomized trial","volume":"41","author":"Patel","year":"2013","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.arth.2018.12.001_bib122","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1007\/s00402-016-2545-2","article-title":"Leukocyte-poor platelet-rich plasma is more effective than the conventional therapy with acetaminophen for the treatment of early knee osteoarthritis","volume":"136","author":"Simental-Mend\u00eda","year":"2016","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/j.arth.2018.12.001_bib123","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1136\/ard.2004.022905","article-title":"Evaluation of clinically relevant changes in patient reported outcomes in knee and hip osteoarthritis: the minimal clinically important improvement","volume":"64","author":"Tubach","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.arth.2018.12.001_bib124","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.arth.2018.12.001_bib125","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1089\/ten.2006.0118","article-title":"A\u00a0comparison between the chondrogenic potential of human bone marrow stem cells (BMSCs) and adipose-derived stem cells (ADSCs) taken from the same donors","volume":"13","author":"Afizah","year":"2007","journal-title":"Tissue Eng"},{"key":"10.1016\/j.arth.2018.12.001_bib126","doi-asserted-by":"crossref","first-page":"90","DOI":"10.2106\/JBJS.M.00058","article-title":"Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a randomized, double-blind, controlled study","volume":"96","author":"Vangsness","year":"2014","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2018.12.001_bib127","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ejrad.2005.08.008","article-title":"Lineage plasticity and cell biology of fibrocartilage and hyaline cartilage: its significance in cartilage repair and replacement","volume":"57","author":"Freemont","year":"2006","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.arth.2018.12.001_bib128","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1002\/art.11365","article-title":"Stem cell therapy in a caprine model of osteoarthritis","volume":"48","author":"Murphy","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.arth.2018.12.001_bib129","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3727\/096368915X689622","article-title":"Clinical trials with mesenchymal stem cells: an update","volume":"25","author":"Squillaro","year":"2016","journal-title":"Cell Transpl"},{"key":"10.1016\/j.arth.2018.12.001_bib130","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1161\/CIRCULATIONAHA.110.955971","article-title":"Differentiation of allogeneic mesenchymal stem cells induces immunogenicity and limits their long-term benefits for myocardial repair","volume":"122","author":"Huang","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.arth.2018.12.001_bib131","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.jcyt.2017.12.009","article-title":"Intra-articular knee implantation of autologous bone marrow-derived mesenchymal stromal cells in rheumatoid arthritis patients with knee involvement: results of a randomized, triple-blind, placebo-controlled phase 1\/2 clinical trial","volume":"20","author":"Shadmanfar","year":"2018","journal-title":"Cytotherapy"},{"key":"10.1016\/j.arth.2018.12.001_bib132","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/s13287-017-0678-z","article-title":"Autologous mesenchymal stem cells or meniscal cells: what is the best cell source for regenerative meniscus treatment in an early osteoarthritis situation?","volume":"8","author":"Zellner","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.arth.2018.12.001_bib133","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.joca.2017.08.015","article-title":"A\u00a0small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee","volume":"26","author":"Deshmukh","year":"2018","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.arth.2018.12.001_bib134","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1136\/bjsports-2016-096793","article-title":"Stem cell injections in knee osteoarthritis: a systematic review of the literature","volume":"51","author":"Pas","year":"2017","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.arth.2018.12.001_bib135","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s00264-017-3400-y","article-title":"In-vitro chondrogenic potential of synovial stem cells and chondrocytes allocated for autologous chondrocyte implantation\u2014a comparison: synovial stem cells as an alternative cell source for autologous chondrocyte implantation","volume":"41","author":"Kubosch","year":"2017","journal-title":"Int Orthop"},{"key":"10.1016\/j.arth.2018.12.001_bib136","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1186\/s13075-016-1195-7","article-title":"Efficacy and safety of adult human bone marrow-derived, cultured, pooled, allogeneic mesenchymal stromal cells (Stempeucel\u00ae): preclinical and clinical trial in osteoarthritis of the knee joint","volume":"18","author":"Gupta","year":"2016","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.arth.2018.12.001_bib137","first-page":"168","article-title":"The healing effect of bone marrow-derived stem cells in knee osteoarthritis: a case report","volume":"5","author":"Mehrabani","year":"2016","journal-title":"World J Plast Surg"},{"key":"10.1016\/j.arth.2018.12.001_bib138","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1177\/0363546516656179","article-title":"One-stage cartilage repair using a hyaluronic acid-based scaffold with activated bone marrow-derived mesenchymal stem cells compared with microfracture: five-year follow-up","volume":"44","author":"Gobbi","year":"2016","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.arth.2018.12.001_bib139","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1016\/j.arthro.2013.09.074","article-title":"Injectable cultured bone marrow-derived mesenchymal stem cells in varus knees with cartilage defects undergoing high tibial osteotomy: a prospective, randomized controlled clinical trial with 2 years\u2019 follow-up","volume":"29","author":"Wong","year":"2013","journal-title":"Arthroscopy"},{"key":"10.1016\/j.arth.2018.12.001_bib140","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1007\/s00167-012-2329-3","article-title":"Mesenchymal stem cells for the treatment of cartilage lesions: from preclinical findings to clinical application in orthopaedics","volume":"21","author":"Filardo","year":"2013","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.arth.2018.12.001_bib141","doi-asserted-by":"crossref","first-page":"206","DOI":"10.5792\/ksrr.17.201","article-title":"Intra-articular injection of bone marrow-derived mesenchymal stem cells leading to better clinical outcomes without difference in MRI outcomes from baseline in patients with knee osteoarthritis","volume":"30","author":"Shin","year":"2018","journal-title":"Knee Surg Relat Res"},{"key":"10.1016\/j.arth.2018.12.001_bib142","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1177\/0363546516662455","article-title":"A\u00a0prospective, single-blind, placebo-controlled trial of bone marrow aspirate concentrate for knee osteoarthritis","volume":"45","author":"Shapiro","year":"2017","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.arth.2018.12.001_bib143","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/s12967-016-0998-2","article-title":"Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: multicenter randomized controlled clinical trial (phase I\/II)","volume":"14","author":"Lamo-Espinosa","year":"2016","journal-title":"J\u00a0Transl Med"},{"key":"10.1016\/j.arth.2018.12.001_bib144","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/jcb.1174","article-title":"Age-related decline in the osteogenic potential of human bone marrow cells cultured in three-dimensional collagen sponges","volume":"82","author":"Mueller","year":"2001","journal-title":"J\u00a0Cell Biochem"},{"key":"10.1016\/j.arth.2018.12.001_bib145","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1097\/TP.0000000000000678","article-title":"Treatment of knee osteoarthritis with allogeneic bone marrow mesenchymal stem cells: a randomized controlled trial","volume":"99","author":"Vega","year":"2015","journal-title":"Transplantation"},{"key":"10.1016\/j.arth.2018.12.001_bib146","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1302\/0301-620X.85B5.13587","article-title":"Tissue-engineered cartilage and bone using stem cells from human infrapatellar fat pads","volume":"85","author":"Dragoo","year":"2003","journal-title":"J\u00a0Bone Joint Surg Br"},{"key":"10.1016\/j.arth.2018.12.001_bib147","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0736-0266(00)00010-3","article-title":"Age- and gender-related changes in the cellularity of human bone marrow and the prevalence of osteoblastic progenitors","volume":"19","author":"Muschler","year":"2001","journal-title":"J\u00a0Orthop Res"},{"key":"10.1016\/j.arth.2018.12.001_bib148","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.bone.2003.07.005","article-title":"Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells","volume":"33","author":"Stenderup","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.arth.2018.12.001_bib149","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1089\/107632702320934010","article-title":"Bone tissue-engineered implants using human bone marrow stromal cells: effect of culture conditions and donor age","volume":"8","author":"Mendes","year":"2002","journal-title":"Tissue Eng"},{"key":"10.1016\/j.arth.2018.12.001_bib150","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1002\/art.21212","article-title":"Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source","volume":"52","author":"Sakaguchi","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.arth.2018.12.001_bib151","doi-asserted-by":"crossref","first-page":"295","DOI":"10.2217\/rme-2017-0152","article-title":"Human adipose-derived mesenchymal stem cells for osteoarthritis: a pilot study with long-term follow-up and repeated injections","volume":"13","author":"Song","year":"2018","journal-title":"Regen Med"},{"key":"10.1016\/j.arth.2018.12.001_bib152","doi-asserted-by":"crossref","first-page":"4758930","DOI":"10.1155\/2017\/4758930","article-title":"Human suprapatellar fat pad-derived mesenchymal stem cells induce chondrogenesis and cartilage repair in a model of severe osteoarthritis","volume":"2017","author":"Munoz-Criado","year":"2017","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.arth.2018.12.001_bib153","doi-asserted-by":"crossref","first-page":"4968724","DOI":"10.1155\/2016\/4968724","article-title":"Adipose derived-mesenchymal stem cells viability and differentiating features for orthopaedic reparative applications: banking of adipose tissue","volume":"2016","author":"Roato","year":"2016","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.arth.2018.12.001_bib154","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.3892\/etm.2016.3791","article-title":"Efficacy of mesenchymal stem cells in treating patients with osteoarthritis of the knee: a meta-analysis","volume":"12","author":"Cui","year":"2016","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.arth.2018.12.001_bib155","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1002\/jor.23349","article-title":"Infrapatellar fat pad-derived mesenchymal stromal cells from osteoarthritis patients: in\u00a0vitro genetic stability and replicative senescence","volume":"35","author":"Neri","year":"2017","journal-title":"J\u00a0Orthop Res"},{"key":"10.1016\/j.arth.2018.12.001_bib156","doi-asserted-by":"crossref","first-page":"847","DOI":"10.5966\/sctm.2015-0245","article-title":"Adipose mesenchymal stromal cell-based therapy for severe osteoarthritis of the knee: a phase I dose-escalation trial","volume":"5","author":"Pers","year":"2016","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.arth.2018.12.001_bib157","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3109\/08916934.2015.1113267","article-title":"Adipose-derived mesenchymal stem cells from infrapatellar fat pad of patients with rheumatoid arthritis and osteoarthritis have comparable immunomodulatory properties","volume":"49","author":"Skalska","year":"2016","journal-title":"Autoimmunity"},{"key":"10.1016\/j.arth.2018.12.001_bib158","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1007\/s00167-013-2807-2","article-title":"Clinical results and second-look arthroscopic findings after treatment with adipose-derived stem cells for knee osteoarthritis","volume":"23","author":"Koh","year":"2015","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.arth.2018.12.001_bib159","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1002\/term.1565","article-title":"Comparison of infrapatellar and subcutaneous adipose tissue stromal vascular fraction and stromal\/stem cells in osteoarthritic subjects","volume":"8","author":"Pires de Carvalho","year":"2014","journal-title":"J\u00a0Tissue Eng Regen Med"},{"key":"10.1016\/j.arth.2018.12.001_bib160","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12967-018-1420-z","article-title":"Safety, tolerability and efficacy of intra-articular Progenza in knee osteoarthritis: a randomized double-blind placebo-controlled single ascending dose study","volume":"16","author":"Kuah","year":"2018","journal-title":"J\u00a0Transl Med"},{"key":"10.1016\/j.arth.2018.12.001_bib161","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.arthro.2015.09.010","article-title":"Adipose-derived mesenchymal stem cells with microfracture versus microfracture alone: 2-year follow-up of a prospective randomized trial","volume":"32","author":"Koh","year":"2016","journal-title":"Arthroscopy"},{"key":"10.1016\/j.arth.2018.12.001_bib162","doi-asserted-by":"crossref","first-page":"e009332","DOI":"10.1136\/bmjopen-2015-009332","article-title":"Adipose derived mesenchymal stem cell therapy in the treatment of isolated knee chondral lesions: design of a randomised controlled pilot study comparing arthroscopic microfracture versus arthroscopic microfracture combined with postoperative mesenchymal","volume":"5","author":"Freitag","year":"2015","journal-title":"BMJ Open"},{"key":"10.1016\/j.arth.2018.12.001_bib163","first-page":"20","article-title":"A\u00a0future in our past: the umbilical cord for orthopaedic tissue engineering","volume":"2","author":"Marmotti","year":"2014","journal-title":"Joints"},{"key":"10.1016\/j.arth.2018.12.001_bib164","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1177\/0363546517697682","article-title":"The placenta: applications in orthopaedic sports medicine","volume":"46","author":"McIntyre","year":"2018","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.arth.2018.12.001_bib165","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1111\/iwj.12491","article-title":"Age-associated changes in regenerative capabilities of mesenchymal stem cell: impact on chronic wounds repair","volume":"13","author":"Yao","year":"2016","journal-title":"Int Wound J"},{"key":"10.1016\/j.arth.2018.12.001_bib166","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1177\/0363546517706138","article-title":"Amniotic mesenchymal stromal cells exhibit preferential osteogenic and chondrogenic differentiation and enhanced matrix production compared with adipose mesenchymal stromal cells","volume":"45","author":"Topoluk","year":"2017","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.arth.2018.12.001_bib167","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1097\/TP.0b013e3182529b76","article-title":"Isolation and characterization of human amniotic mesenchymal stem cells and their chondrogenic differentiation","volume":"93","author":"Nogami","year":"2012","journal-title":"Transplantation"},{"key":"10.1016\/j.arth.2018.12.001_bib168","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.jcyt.2013.03.002","article-title":"Investigating the efficacy of amnion-derived compared with bone marrow-derived mesenchymal stromal cells in equine tendon and ligament injuries","volume":"15","author":"Lange-Consiglio","year":"2013","journal-title":"Cytotherapy"},{"key":"10.1016\/j.arth.2018.12.001_bib169","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/term.465","article-title":"Characterization and potential applications of progenitor-like cells isolated from horse amniotic membrane","volume":"6","author":"Lange-Consiglio","year":"2012","journal-title":"J\u00a0Tissue Eng Regen Med"},{"key":"10.1016\/j.arth.2018.12.001_bib170","first-page":"91","article-title":"The amniotic membrane as a source of stem cells","volume":"25","author":"Insausti","year":"2010","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.arth.2018.12.001_bib171","series-title":"Interventional Orthopedics Foundation shines light on false claims about stem cell products","year":"2015"},{"key":"10.1016\/j.arth.2018.12.001_bib172","author":"Stiene"},{"key":"10.1016\/j.arth.2018.12.001_bib173","first-page":"443","article-title":"Cryopreserved amniotic suspension for the treatment of knee osteoarthritis","volume":"29","author":"Vines","year":"2016","journal-title":"J\u00a0Knee Surg"},{"key":"10.1016\/j.arth.2018.12.001_bib174","doi-asserted-by":"crossref","first-page":"613","DOI":"10.5966\/sctm.2016-0157","article-title":"Cartilage regeneration in osteoarthritic patients by a composite of allogeneic umbilical cord blood-derived mesenchymal stem cells and hyaluronate hydrogel: results from a clinical trial for safety and proof-of-concept with 7 years of extended follow-up","volume":"6","author":"Park","year":"2017","journal-title":"Stem Cells Transl Med"}],"container-title":["The Journal of Arthroplasty"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540318311835?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540318311835?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T15:06:12Z","timestamp":1775315172000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883540318311835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":174,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S0883540318311835"],"URL":"https:\/\/doi.org\/10.1016\/j.arth.2018.12.001","relation":{},"ISSN":["0883-5403"],"issn-type":[{"value":"0883-5403","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biologic Therapies for the Treatment of Knee Osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"The Journal of Arthroplasty","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arth.2018.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}