{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T11:23:50Z","timestamp":1792409030284,"version":"4.4.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["arthroplastyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Arthroplasty"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.arth.2021.03.035","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T01:09:29Z","timestamp":1616116169000},"page":"2951-2956","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Incomplete Administration of Intravenous Vancomycin Prophylaxis is Common and Associated With Increased Infectious Complications After Primary Total Hip and Knee Arthroplasty"],"prefix":"10.1016","volume":"36","author":[{"given":"Oren I.","family":"Feder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Yeroushalmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles C.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S.","family":"Galetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moretza","family":"Meftah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudette M.","family":"Lajam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Slover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Schwarzkopf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Joseph A.","family":"Bosco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Macaulay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arth.2021.03.035_bib1","article-title":"Prevention of periprosthetic joint infection","author":"Shahi","year":"2015","journal-title":"Arch Bone Jt Surg"},{"key":"10.1016\/j.arth.2021.03.035_bib2","doi-asserted-by":"crossref","DOI":"10.1302\/0301-620X.90B7.20498","article-title":"Antibiotic prophylaxis for wound infections in total joint arthroplasty: a systematic review","author":"AlBuhairn","year":"2008","journal-title":"J\u00a0Bone Joint Surg Br"},{"key":"10.1016\/j.arth.2021.03.035_bib3","article-title":"Re-emphasis of priorities in surgical antibiotic prophylaxis","author":"Galandiuk","year":"1989","journal-title":"Surg Gynecol Obstet"},{"key":"10.1016\/j.arth.2021.03.035_bib4","article-title":"Timing of preoperative antibiotic prophylaxis in 54,552 patients and the risk of surgical site infection","author":"De Jonge","year":"2017","journal-title":"Medicine (United States)"},{"key":"10.1016\/j.arth.2021.03.035_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.arth.2013.09.030","article-title":"Perioperative Antibiotics","author":"Hansen","year":"2014","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2021.03.035_bib6","article-title":"Tests for penicillin allergy in man. II. The immunological cross reaction between penicillins and cephalosporins","year":"1974","journal-title":"Immunology"},{"key":"10.1016\/j.arth.2021.03.035_bib7","doi-asserted-by":"crossref","DOI":"10.5435\/JAAOS-D-15-00017","article-title":"Principles of antibiotic prophylaxis in total joint arthroplasty: current concepts","author":"Bosco","year":"2015","journal-title":"J\u00a0Am Acad Orthop Surg"},{"key":"10.1016\/j.arth.2021.03.035_bib8","doi-asserted-by":"crossref","DOI":"10.1186\/cc1871","article-title":"Red man syndrome","author":"Sivagnanam","year":"2003","journal-title":"Crit Care"},{"key":"10.1016\/j.arth.2021.03.035_bib9","doi-asserted-by":"crossref","DOI":"10.1542\/peds.86.4.572","article-title":"Vancomycin-induced red man syndrome","author":"Levy","year":"1990","journal-title":"Pediatrics"},{"key":"10.1016\/j.arth.2021.03.035_bib10","doi-asserted-by":"crossref","DOI":"10.1097\/INF.0b013e31824e10d7","article-title":"Defining risk factors for red man syndrome in children and adults","author":"Myers","year":"2012","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.arth.2021.03.035_bib11","doi-asserted-by":"crossref","DOI":"10.1093\/infdis\/157.3.502","article-title":"Vancomycin and the red-man syndrome: pharmacodynamics of histamine release","author":"Polk","year":"1988","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.arth.2021.03.035_bib12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1089\/sur.2013.9999","article-title":"Clinical practice guidelines for antimicrobial prophylaxis in surgery","volume":"14","author":"Bratzler","year":"2013","journal-title":"Surg Infect (Larchmt)"},{"key":"10.1016\/j.arth.2021.03.035_bib13","doi-asserted-by":"crossref","first-page":"283","DOI":"10.5435\/00124635-200805000-00007","article-title":"Prophylactic antibiotics in orthopaedic surgery","volume":"16","author":"Prokuski","year":"2008","journal-title":"J\u00a0Am Acad Orthop Surg"},{"key":"10.1016\/j.arth.2021.03.035_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.arth.2018.02.078","article-title":"The 2018 Definition of Periprosthetic Hip and Knee Infection: An Evidence-Based and Validated Criteria","author":"Parvizi","year":"2018","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2021.03.035_bib15","article-title":"Prophylactic antibiotics in orthopaedic surgery","author":"Prokuski","year":"2011","journal-title":"Instr Course Lect"},{"key":"10.1016\/j.arth.2021.03.035_bib16","doi-asserted-by":"crossref","DOI":"10.4065\/75.9.902","article-title":"Reduction of vancomycin use in orthopedic patients with a history of antibiotic allergy","author":"Li","year":"2000","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.arth.2021.03.035_bib17","doi-asserted-by":"crossref","DOI":"10.1007\/s11999-017-5302-0","article-title":"Vancomycin prophylaxis for total joint arthroplasty: incorrectly dosed and has a higher rate of periprosthetic infection than Cefazolin","author":"Kheir","year":"2017","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2021.03.035_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.arth.2018.03.009","article-title":"Dual-agent antibiotic prophylaxis using a single preoperative vancomycin dose effectively reduces prosthetic joint infection rates with minimal renal toxicity risk","author":"Burger","year":"2018","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2021.03.035_bib19","doi-asserted-by":"crossref","DOI":"10.1007\/s11999-017-5289-6","article-title":"Increased mortality after prosthetic joint infection in primary THA","author":"Gundtoft","year":"2017","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2021.03.035_bib20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.arth.2010.04.011","article-title":"Periprosthetic joint infection: the economic impact of methicillin-resistant infections","volume":"25","author":"Parvizi","year":"2010","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2021.03.035_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajic.2008.12.010","article-title":"Surgical site infection: incidence and impact on hospital utilization and treatment costs","author":"de Lissovoy","year":"2009","journal-title":"Am J Infect Control"},{"key":"10.1016\/j.arth.2021.03.035_bib22","article-title":"Complications of total knee arthroplasty: standardized list and definitions of the knee society knee","author":"Healy","year":"2013","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2021.03.035_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.arth.2018.08.021","article-title":"Mortality during total knee periprosthetic joint infection","author":"Lum","year":"2018","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2021.03.035_bib24","doi-asserted-by":"crossref","DOI":"10.1089\/sur.2015.067","article-title":"Effect of body weight on Cefazolin and vancomycin trabecular bone concentrations in patients undergoing total joint arthroplasty","author":"Sharareh","year":"2016","journal-title":"Surg Infect (Larchmt)"},{"key":"10.1016\/j.arth.2021.03.035_bib25","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11999-013-3038-z","article-title":"The Mark Coventry Award: higher tissue concentrations of vancomycin with low-dose intraosseous regional versus systemic prophylaxis in TKA: a randomized trial","volume":"472","author":"Young","year":"2014","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2021.03.035_bib26","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s11999.0000000000000013","article-title":"The John N. Insall award: higher tissue concentrations of vancomycin achieved with intraosseous regional prophylaxis in revision TKA: a randomized controlled trial","volume":"476","author":"Young","year":"2018","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2021.03.035_bib27","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1007\/s11999-015-4464-x","article-title":"Regional intraosseous administration of prophylactic antibiotics is more effective than systemic administration in a mouse model of TKA","volume":"473","author":"Young","year":"2015","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2021.03.035_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.artd.2020.02.001","article-title":"Clinical outcome evaluation of intraosseous vancomycin in total knee arthroplasty","author":"Harper","year":"2020","journal-title":"Arthroplast Today"},{"key":"10.1016\/j.arth.2021.03.035_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.arth.2020.07.064","article-title":"Topical vancomycin powder and dilute povidone-iodine lavage reduce the rate of early periprosthetic joint infection after primary total knee arthroplasty","author":"Buchalter","year":"2021","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2021.03.035_bib30","article-title":"Prophylactic antibiotic management of surgical patients noted as \u201callergic\u201d to penicillin at two academic hospitals","author":"Epstein","year":"2016","journal-title":"A\u00a0A Case Rep"},{"key":"10.1016\/j.arth.2021.03.035_bib31","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.jemermed.2011.05.035","article-title":"The use of cephalosporins in penicillin-allergic patients: a literature review","volume":"42","author":"Campagna","year":"2012","journal-title":"J\u00a0Emerg Med"},{"key":"10.1016\/j.arth.2021.03.035_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.arth.2018.06.037","article-title":"Cefazolin prophylaxis for total joint arthroplasty: obese patients are frequently underdosed and at increased risk of periprosthetic joint infection","author":"Rondon","year":"2018","journal-title":"J\u00a0Arthroplasty"}],"container-title":["The Journal of Arthroplasty"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540321002850?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540321002850?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:37:37Z","timestamp":1760121457000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883540321002850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S0883540321002850"],"URL":"https:\/\/doi.org\/10.1016\/j.arth.2021.03.035","relation":{},"ISSN":["0883-5403"],"issn-type":[{"value":"0883-5403","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Incomplete Administration of Intravenous Vancomycin Prophylaxis is Common and Associated With Increased Infectious Complications After Primary Total Hip and Knee Arthroplasty","name":"articletitle","label":"Article Title"},{"value":"The Journal of Arthroplasty","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arth.2021.03.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}