{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:04:56Z","timestamp":1792872296980,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["arthroplastyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Arthroplasty"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.arth.2022.02.096","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T11:35:14Z","timestamp":1646220914000},"page":"1438-1440","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Irrigation Solutions and Antibiotic Powders: Should I Use Them in Primary and Revision Total Joint Arthroplasty?"],"prefix":"10.1016","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6198-5075","authenticated-orcid":false,"given":"Bryan D.","family":"Springer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arth.2022.02.096_bib1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.7150\/jbji.16448","article-title":"Treatment of periprosthetic joint infection using antimicrobials: dilute povidone-iodine lavage","volume":"2","author":"Ruder","year":"2017","journal-title":"J\u00a0Bone Jt Infect"},{"key":"10.1016\/j.arth.2022.02.096_bib2","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2106\/JBJS.M.00313","article-title":"Selection of an optimal antiseptic solution for intraoperative irrigation: an in\u00a0vitro study","volume":"96","author":"Van Meurs","year":"2014","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2022.02.096_bib3","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.1016\/j.arth.2021.05.032","article-title":"What is the optimal irrigation solution in the management of periprosthetic hip and knee joint infections?","volume":"36","author":"Siddiqi","year":"2021","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2022.02.096_bib4","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/0002-9610(86)90477-0","article-title":"Chemical and microbiologic characteristics and toxicity of povidone-iodine solutions","volume":"151","author":"Zamora","year":"1986","journal-title":"Am J Surg"},{"key":"10.1016\/j.arth.2022.02.096_bib5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.arth.2011.03.034","article-title":"Dilute betadine lavage before closure for the prevention of acute postoperative deep periprosthetic joint infection","volume":"27","author":"Brown","year":"2012","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2022.02.096_bib6","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.2106\/JBJS.18.01285","article-title":"Use of povidone-iodine irrigation prior to wound closure in primary total hip and knee arthroplasty: an analysis of 11,738 cases","volume":"101","author":"Hernandez","year":"2019","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2022.02.096_bib7","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.2106\/JBJS.18.01152","article-title":"Povidone-iodine wound lavage to prevent infection after revision total hip and knee arthroplasty: an analysis of 2,884 cases","volume":"101","author":"Hart","year":"2019","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2022.02.096_bib8","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.arth.2021.10.026","article-title":"Dilute povidone-iodine irrigation reduces the rate of periprosthetic joint infection following hip and knee arthroplasty: an analysis of 31,331 cases","volume":"37","author":"Shohat","year":"2021","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2022.02.096_bib9","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.arth.2013.02.018","article-title":"Deleterious effects of diluted povidone\u2013iodine on articular cartilage","volume":"28","author":"von Keudell","year":"2013","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2022.02.096_bib10","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1177\/0310057X0803600404","article-title":"Chlorhexidine-pharmacology and clinical applications","volume":"36","author":"Lim","year":"2008","journal-title":"Anaesth Intensive Care"},{"key":"10.1016\/j.arth.2022.02.096_bib11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.7150\/jbji.16934","article-title":"Use of chlorhexidine preparations in total joint arthroplasty","volume":"2","author":"George","year":"2017","journal-title":"J\u00a0Bone Jt Infect"},{"key":"10.1016\/j.arth.2022.02.096_bib12","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/j.arth.2015.05.005","article-title":"Optimal irrigation and debridement of infected total joint implants with chlorhexidine gluconate","volume":"30","author":"Smith","year":"2015","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2022.02.096_bib13","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.arth.2021.10.013","article-title":"What is the duration of irrigation? An in-vitro study of the minimum exposure time to eradicate bacteria with irrigation solutions","volume":"37","author":"Christopher","year":"2021","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2022.02.096_bib14","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.artd.2017.03.005","article-title":"Intraoperative chlorhexidine irrigation to prevent infection in total hip and knee arthroplasty","volume":"3","author":"Frisch","year":"2017","journal-title":"Arthroplasty Today"},{"key":"10.1016\/j.arth.2022.02.096_bib15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.7150\/jbji.16690","article-title":"Hydrogen peroxide wound irrigation in orthopaedic surgery","volume":"2","author":"Lu","year":"2017","journal-title":"J\u00a0Bone Jt Infect"},{"key":"10.1016\/j.arth.2022.02.096_bib16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1302\/2046-3758.81.BJR-2018-0145.R1","article-title":"Bactericidal efficacy of hydrogen peroxide on Cutibacterium acnes","volume":"8","author":"Hernandez","year":"2019","journal-title":"Bone Joint Res"},{"key":"10.1016\/j.arth.2022.02.096_bib17","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/00005131-199509040-00006","article-title":"Toxic effects of wound irrigation solutions on cultured tibiae and osteoblasts","volume":"9","author":"Kaysinger","year":"1995","journal-title":"J\u00a0Orthop Trauma"},{"key":"10.1016\/j.arth.2022.02.096_bib18","first-page":"379","article-title":"A\u00a0comparative study of the effect of hydrogen peroxide versus normal saline on the strength of the bone\u2013cement interface","volume":"17","author":"Guerin","year":"2007","journal-title":"Biomed Mater Eng"},{"key":"10.1016\/j.arth.2022.02.096_bib19","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0883-5403(89)80039-7","article-title":"Cardiac arrest following the use of hydrogen peroxide during arthroplasty","volume":"4","author":"Timperley","year":"1989","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2022.02.096_bib20","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1016\/j.arth.2015.05.047","article-title":"Single-stage hip and knee exchange for periprosthetic joint infection","volume":"30","author":"George","year":"2015","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2022.02.096_bib21","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.arth.2011.04.022","article-title":"Dislocation and infection after revision total hip arthroplasty: comparison between the first and multiply revised total hip arthroplasty","volume":"26","author":"Kosashvili","year":"2011","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2022.02.096_bib22","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1089\/wound.2014.0554","article-title":"Antibiofilm properties of acetic acid","volume":"4","author":"Bjarnsholt","year":"2015","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"10.1016\/j.arth.2022.02.096_bib23","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1302\/2046-3758.78.BJR-2018-0045.R1","article-title":"The biofilm eradication activity of acetic acid in the management of periprosthetic joint infection","volume":"7","author":"Tsang","year":"2018","journal-title":"Bone Joint Res"},{"key":"10.1016\/j.arth.2022.02.096_bib24","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.arth.2016.09.010","article-title":"Acetic acid as part of a debridement protocol during revision total knee arthroplasty","volume":"32","author":"Williams","year":"2017","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2022.02.096_bib25","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/00003086-199804000-00027","article-title":"Pharmacokinetics of a degradable drug delivery system in bone","volume":"349","author":"Humphrey","year":"1998","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2022.02.096_bib26","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/neuros\/nyy288","article-title":"Impact of powdered vancomycin on preventing surgical site infections in neurosurgery: a systematic review and meta-analysis","volume":"84","author":"Texakalidis","year":"2019","journal-title":"Neurosurgery"},{"key":"10.1016\/j.arth.2022.02.096_bib27","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1016\/j.arth.2019.03.071","article-title":"Systematic review and meta-analysis of intrawound vancomycin in total hip and total knee arthroplasty: a call for a prospective randomized trial","volume":"34","author":"Heckmann","year":"2019","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2022.02.096_bib28","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.arth.2017.10.044","article-title":"Vancomycin povidone-iodine protocol improves survivorship of periprosthetic joint infection treated with irrigation and debridement","volume":"33","author":"Riesgo","year":"2018","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2022.02.096_bib29","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1089\/sur.2015.264","article-title":"Evidence-based update to the US centers for disease control and prevention and healthcare infection control practices advisory committee guideline for the prevention of surgical site infection: developmental process","volume":"17","author":"Berr\u00edos-Torres","year":"2016","journal-title":"Surg Infect"}],"container-title":["The Journal of Arthroplasty"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540322002479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540322002479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:40:42Z","timestamp":1760121642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883540322002479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S0883540322002479"],"URL":"https:\/\/doi.org\/10.1016\/j.arth.2022.02.096","relation":{},"ISSN":["0883-5403"],"issn-type":[{"value":"0883-5403","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Irrigation Solutions and Antibiotic Powders: Should I Use Them in Primary and Revision Total Joint Arthroplasty?","name":"articletitle","label":"Article Title"},{"value":"The Journal of Arthroplasty","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arth.2022.02.096","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}