{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:40:10Z","timestamp":1786984810187,"version":"build-2736575974"},"reference-count":30,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["arthroplastyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Arthroplasty"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.arth.2022.06.016","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T22:11:36Z","timestamp":1655849496000},"page":"2437-2443.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Synovial C-Reactive Protein is a Useful Adjunct for Diagnosis of Periprosthetic Joint Infection"],"prefix":"10.1016","volume":"37","author":[{"given":"Colin M.","family":"Baker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7337-3321","authenticated-orcid":false,"given":"Graham S.","family":"Goh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3866-4657","authenticated-orcid":false,"given":"Saad","family":"Tarabichi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noam","family":"Shohat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6985-5870","authenticated-orcid":false,"given":"Javad","family":"Parvizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arth.2022.06.016_bib1","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1097\/CORR.0000000000001838","article-title":"What are the long-term outcomes of mortality, quality of life, and hip function after prosthetic joint infection of the hip? A 10-year follow-up from Sweden","volume":"479","author":"Wildeman","year":"2021","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2022.06.016_bib2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.arth.2012.02.022","article-title":"Economic burden of periprosthetic joint infection in the United States","volume":"27","author":"Kurtz","year":"2012","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2022.06.016_bib3","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.arth.2021.10.018","article-title":"Hospital costs for unsuccessful two-stage revisions for periprosthetic joint infection","volume":"37","author":"Kurtz","year":"2022","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2022.06.016_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.arth.2022.01.061","article-title":"Diagnosis and treatment of culture-negative periprosthetic joint infection","author":"Goh","year":"2022","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2022.06.016_bib5","series-title":"Infection in knee replacement","first-page":"61","article-title":"Laboratory diagnosis of periprosthetic joint infections","author":"Goh","year":"2022"},{"key":"10.1016\/j.arth.2022.06.016_bib7","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.arth.2018.02.078","article-title":"The 2018 definition of periprosthetic hip and knee infection: an evidence-based and validated criteria","volume":"33","author":"Parvizi","year":"2018","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2022.06.016_bib8","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1302\/0301-620X.95B11.33135","article-title":"Proceedings of the international consensus on periprosthetic joint infection","volume":"95-B","author":"Parvizi","year":"2013","journal-title":"Bone Joint J"},{"key":"10.1016\/j.arth.2022.06.016_bib9","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1007\/s11999-014-3543-8","article-title":"Diagnosing periprosthetic joint infection: has the era of the biomarker arrived?","volume":"472","author":"Deirmengian","year":"2014","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2022.06.016_bib10","doi-asserted-by":"crossref","first-page":"754","DOI":"10.3389\/fimmu.2018.00754","article-title":"Role of C-reactive protein at sites of inflammation and infection","volume":"9","author":"Sproston","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.arth.2022.06.016_bib11","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s11999-011-1991-y","article-title":"Coventry award: synovial C-reactive protein: a prospective evaluation of a molecular marker for periprosthetic knee joint infection","volume":"470","author":"Parvizi","year":"2012","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2022.06.016_bib12","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1007\/s00167-018-4904-8","article-title":"A\u00a0meta-analysis of synovial biomarkers in periprosthetic joint infection: SynovasureTM is less effective than the ELISA-based alpha-defensin test","volume":"26","author":"Ahmad","year":"2018","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.arth.2022.06.016_bib13","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.2106\/JBJS.17.00123","article-title":"Synovial fluid biomarkers for the diagnosis of periprosthetic joint infection: a systematic review and meta-analysis","volume":"99","author":"Lee","year":"2017","journal-title":"J\u00a0Bone Joint Surg"},{"key":"10.1016\/j.arth.2022.06.016_bib14","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.arth.2012.03.018","article-title":"Diagnosis of periprosthetic joint infection using synovial C-reactive protein","volume":"27","author":"Parvizi","year":"2012","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2022.06.016_bib15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1302\/0301-620X.97B2.34550","article-title":"Synovial C-reactive protein as a marker for chronic periprosthetic infection in total hip arthroplasty","volume":"97-B","author":"Omar","year":"2015","journal-title":"Bone Joint J"},{"key":"10.1016\/j.arth.2022.06.016_bib16","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1007\/s11999-014-3828-y","article-title":"Is synovial C-reactive protein a useful marker for periprosthetic joint infection?","volume":"472","author":"Tetreault","year":"2014","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2022.06.016_bib17","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1302\/0301-620X.99B3.BJJ-2016-0684.R1","article-title":"Improving the accuracy of synovial fluid analysis in the diagnosis of prosthetic joint infection with simple and inexpensive biomarkers: C-reactive protein and adenosine deaminase","volume":"99-B","author":"Sousa","year":"2017","journal-title":"Bone Joint J"},{"key":"10.1016\/j.arth.2022.06.016_bib18","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.2106\/JBJS.17.00556","article-title":"Clinical evaluation of synovial alpha defensin and synovial C-reactive protein in the diagnosis of periprosthetic joint infection","volume":"100","author":"Stone","year":"2018","journal-title":"J\u00a0Bone Joint Surg"},{"key":"10.1016\/j.arth.2022.06.016_bib19","first-page":"439","article-title":"Synovial C-reactive protein features high negative predictive value but is not useful as a single diagnostic parameter in suspected periprosthetic joint infection (PJI)","volume":"78","author":"Plate","year":"2019","journal-title":"J\u00a0Infect"},{"key":"10.1016\/j.arth.2022.06.016_bib20","doi-asserted-by":"crossref","first-page":"102903","DOI":"10.1016\/j.otsr.2021.102903","article-title":"Value of the synovial C-reactive protein test in the diagnosis of total hip and knee periprosthetic joint infections: a case-control study","volume":"107","author":"Praz","year":"2021","journal-title":"Orthop Traumatol Surg Res"},{"key":"10.1016\/j.arth.2022.06.016_bib21","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1186\/s12891-021-04545-6","article-title":"Combined serum and synovial C-reactive protein tests: a valuable adjunct to the diagnosis of chronic prosthetic joint infection","volume":"22","author":"Wang","year":"2021","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.arth.2022.06.016_bib22","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1186\/s13018-021-02880-x","article-title":"The relationship of C-reactive protein\/interleukin-6 concentrations between serum and synovial fluid in the diagnosis of periprosthetic joint infection","volume":"16","author":"Yu","year":"2021","journal-title":"J\u00a0Orthop Surg Res"},{"key":"10.1016\/j.arth.2022.06.016_bib23","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.2106\/JBJS.19.00598","article-title":"Diagnosis of periprosthetic infection: recent developments","volume":"102","author":"Wasterlain","year":"2020","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2022.06.016_bib24","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A\u00a0new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J\u00a0Chronic Dis"},{"key":"10.1016\/j.arth.2022.06.016_bib25","series-title":"ASA Physical Status Classification System","year":"2014"},{"key":"10.1016\/j.arth.2022.06.016_bib26","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.4103\/0366-6999.187857","article-title":"Synovial fluid C-reactive protein as a diagnostic marker for periprosthetic joint infection: a systematic review and meta-analysis","volume":"129","author":"Wang","year":"2016","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.arth.2022.06.016_bib27","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.2106\/JBJS.18.01052","article-title":"Saline solution lavage and reaspiration for culture with a blood culture system is a feasible method for diagnosing periprosthetic joint infection in patients with insufficient synovial fluid","volume":"101","author":"Li","year":"2019","journal-title":"J\u00a0Bone Joint Surg"},{"key":"10.1016\/j.arth.2022.06.016_bib28","doi-asserted-by":"crossref","first-page":"R229","DOI":"10.1186\/ar3216","article-title":"Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254)","volume":"12","author":"Catterall","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.arth.2022.06.016_bib29","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1051\/sicotj\/2021054","article-title":"Diagnosis and management of infected arthroplasty","volume":"7","author":"Pannu","year":"2021","journal-title":"SICOT J"},{"key":"10.1016\/j.arth.2022.06.016_bib30","doi-asserted-by":"crossref","first-page":"ofac048","DOI":"10.1093\/ofid\/ofac048","article-title":"Predictors of treatment success after periprosthetic joint infection: 24-month follow up from a multicenter prospective observational cohort study of 653 patients","volume":"9","author":"Davis","year":"2022","journal-title":"Open Forum Infect Dis"},{"key":"10.1016\/j.arth.2022.06.016_bib31","doi-asserted-by":"crossref","first-page":"S187","DOI":"10.1016\/j.arth.2018.09.070","article-title":"General assembly, diagnosis, laboratory test: Proceedings of international consensus on orthopedic infections","volume":"34","author":"Barrack","year":"2019","journal-title":"J\u00a0Arthroplasty"}],"container-title":["The Journal of Arthroplasty"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540322006787?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540322006787?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:43:24Z","timestamp":1760121804000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883540322006787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S0883540322006787"],"URL":"https:\/\/doi.org\/10.1016\/j.arth.2022.06.016","relation":{},"ISSN":["0883-5403"],"issn-type":[{"value":"0883-5403","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synovial C-Reactive Protein is a Useful Adjunct for Diagnosis of Periprosthetic Joint Infection","name":"articletitle","label":"Article Title"},{"value":"The Journal of Arthroplasty","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arth.2022.06.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}