{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:15:16Z","timestamp":1790082916708,"version":"4.0.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["arthroplastyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Arthroplasty"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.arth.2022.08.028","type":"journal-article","created":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T20:37:00Z","timestamp":1661632620000},"page":"224-231.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Is Intraoperative Dexamethasone Utilization Associated With Increased Rates of Periprosthetic Joint Infection Following Total Joint Arthroplasty?"],"prefix":"10.1016","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1293-1702","authenticated-orcid":false,"given":"Nathanael D.","family":"Heckmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1306-8026","authenticated-orcid":false,"given":"Jennifer C.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit S.","family":"Piple","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenda A.","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1777-2969","authenticated-orcid":false,"given":"Emily S.","family":"Mills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin C.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay R.","family":"Lieberman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander B.","family":"Christ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arth.2022.08.028_bib1","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.2106\/00004623-200606000-00029","article-title":"Efficacy and safety of steroid use for postoperative pain relief. Update and review of the medical literature","volume":"88","author":"Salerno","year":"2006","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2022.08.028_bib2","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1097\/AJP.0000000000000486","article-title":"A\u00a0narrative review of the evidence on the efficacy of dexamethasone on postoperative analgesic consumption","volume":"33","author":"Batistaki","year":"2017","journal-title":"Clin J Pain"},{"key":"10.1016\/j.arth.2022.08.028_bib3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.arth.2013.05.041","article-title":"Dexamethasone reduces length of hospitalization and improves postoperative pain and nausea after total joint arthroplasty: a prospective, randomized controlled trial","volume":"28","author":"Backes","year":"2013","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2022.08.028_bib4","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1007\/s11999-013-3032-5","article-title":"Preemptive low-dose dexamethasone reduces postoperative emesis and pain after TKA: a randomized controlled study","volume":"471","author":"Koh","year":"2013","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2022.08.028_bib5","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1186\/s12891-018-2359-1","article-title":"Perioperative multiple low-dose Dexamethasones improves postoperative clinical outcomes after total knee arthroplasty","volume":"19","author":"Wu","year":"2018","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.arth.2022.08.028_bib6","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1007\/s00167-017-4506-x","article-title":"Two doses of low-dose perioperative dexamethasone improve the clinical outcome after total knee arthroplasty: a randomized controlled study","volume":"26","author":"Xu","year":"2018","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.arth.2022.08.028_bib7","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1399-6576.2009.02126.x","article-title":"Dexamethasone decreases oxycodone consumption following osteotomy of the first metatarsal bone: a randomized controlled trial in day surgery","volume":"54","author":"Mattila","year":"2010","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.arth.2022.08.028_bib8","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1097\/01.brs.0000238668.49035.19","article-title":"Effect of high-dose intravenous dexamethasone on postlumbar discectomy pain","volume":"31","author":"Aminmansour","year":"2006","journal-title":"Spine"},{"key":"10.1016\/j.arth.2022.08.028_bib9","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1016\/j.jse.2020.12.005","article-title":"Dexamethasone decreases postoperative opioid and antiemetic use in shoulder arthroplasty patients: a prospective, randomized controlled trial","volume":"30","author":"Klag","year":"2021","journal-title":"J\u00a0Shoulder Elbow Surg"},{"key":"10.1016\/j.arth.2022.08.028_bib10","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1016\/j.arth.2018.07.013","article-title":"Does dexamethasone reduce hospital readiness for discharge, pain, nausea, and early patient satisfaction in hip and knee arthroplasty? A randomized, controlled trial","volume":"33","author":"Dissanayake","year":"2018","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2022.08.028_bib11","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.arth.2020.10.010","article-title":"Perioperative systemic dexamethasone reduces length of stay in total joint arthroplasty: a systematic review and meta-analysis of randomized controlled trials","volume":"36","author":"Lex","year":"2021","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2022.08.028_bib12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.arth.2018.08.033","article-title":"Do corticosteroids attenuate the peri-operative acute phase response after total knee arthroplasty?","volume":"34","author":"Brekke","year":"2019","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2022.08.028_bib13","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/os.12664","article-title":"Combined application of dexamethasone and tranexamic acid to reduce the postoperative inflammatory response and improve functional outcomes in total hip arthroplasty","volume":"12","author":"An","year":"2020","journal-title":"Orthop Surg"},{"key":"10.1016\/j.arth.2022.08.028_bib14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11999-016-4757-8","article-title":"The John N. Insall award: do intraarticular injections increase the risk of infection after TKA?","volume":"475","author":"Bedard","year":"2017","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2022.08.028_bib15","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1016\/j.arth.2015.05.027","article-title":"Does timing of previous intra-articular steroid injection affect the post-operative rate of infection in total knee arthroplasty?","volume":"30","author":"Cancienne","year":"2015","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2022.08.028_bib16","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.arth.2018.12.014","article-title":"The effects of peri-operative dexamethasone on patients undergoing total hip or knee arthroplasty: is it safe for diabetics?","volume":"34","author":"Godshaw","year":"2019","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2022.08.028_bib17","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1016\/j.arth.2016.01.028","article-title":"Perioperative dexamethasone administration does not increase the incidence of postoperative infection in total hip and knee arthroplasty: a retrospective analysis","volume":"31","author":"Richardson","year":"2016","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2022.08.028_bib18","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1007\/s00264-018-4156-8","article-title":"Infection safety of dexamethasone in total hip and total knee arthroplasty: a study of eighteen thousand, eight hundred and seventy two operations","volume":"43","author":"Vuorinen","year":"2019","journal-title":"Int Orthop"},{"key":"10.1016\/j.arth.2022.08.028_bib19","doi-asserted-by":"crossref","first-page":"3252","DOI":"10.1016\/j.arth.2018.05.016","article-title":"Intraoperative dexamethasone reduces readmission rates without affecting risk of thromboembolic events or infection after total joint arthroplasty","volume":"33","author":"Klement","year":"2018","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2022.08.028_bib20","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/MLR.0000000000000905","article-title":"Validation of the combined comorbidity index of Charlson and elixhauser to predict 30-day mortality across ICD-9 and ICD-10","volume":"56","author":"Simard","year":"2018","journal-title":"Med Care"},{"key":"10.1016\/j.arth.2022.08.028_bib21","first-page":"CD011940","article-title":"Adverse side effects of dexamethasone in surgical patients","volume":"11","author":"Polderman","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.arth.2022.08.028_bib22","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/00003086-198811000-00027","article-title":"Inhibition of complement activation by high-dose corticosteroids in total hip arthroplasty","volume":"236","author":"Gammer","year":"1988","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2022.08.028_bib23","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/j.arth.2017.11.057","article-title":"Multiple low-dose dexamethasone further improves clinical outcomes following total hip arthroplasty","volume":"33","author":"Lei","year":"2018","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2022.08.028_bib24","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1016\/j.arth.2018.06.031","article-title":"Multiple doses of perioperative dexamethasone further improve clinical outcomes after total knee arthroplasty: a prospective, randomized, controlled study","volume":"33","author":"Xu","year":"2018","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2022.08.028_bib25","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.thromres.2018.09.054","article-title":"Efficacy and safety of multiple boluses of oral versus intravenous tranexamic acid at reducing blood loss after primary total knee arthroplasty without a tourniquet: a prospective randomized clinical trial","volume":"171","author":"Cao","year":"2018","journal-title":"Thromb Res"},{"key":"10.1016\/j.arth.2022.08.028_bib26","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00264-017-3537-8","article-title":"The efficacy and safety of two low-dose peri-operative dexamethasone on pain and recovery following total hip arthroplasty: a randomized controlled trial","volume":"42","author":"Lei","year":"2018","journal-title":"Int Orthop"},{"key":"10.1016\/j.arth.2022.08.028_bib27","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41569-021-00552-1","article-title":"Interplay between inflammation and thrombosis in cardiovascular pathology","volume":"18","author":"Stark","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.arth.2022.08.028_bib28","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1055\/s-0035-1556726","article-title":"Postsurgical inflammation as a causative mechanism of venous thromboembolism","volume":"41","author":"Albayati","year":"2015","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.arth.2022.08.028_bib29","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1161\/01.RES.0000163015.67711.AB","article-title":"Activation of inflammation and coagulation after infusion of C-reactive protein in humans","volume":"96","author":"Bisoendial","year":"2005","journal-title":"Circ Res"},{"key":"10.1016\/j.arth.2022.08.028_bib30","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.atherosclerosis.2008.05.060","article-title":"C-reactive protein stimulates superoxide anion release and tissue factor activity in\u00a0vivo","volume":"203","author":"Devaraj","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.arth.2022.08.028_bib31","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1182\/blood-2016-11-749879","article-title":"Distinct contributions of complement factors to platelet activation and fibrin formation in venous thrombus development","volume":"129","author":"Subramaniam","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.arth.2022.08.028_bib32","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1182\/blood-2017-03-771501","article-title":"Complement and clot","volume":"129","author":"Afshar-Kharghan","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.arth.2022.08.028_bib33","doi-asserted-by":"crossref","first-page":"SCI-40","DOI":"10.1182\/blood-2019-121113","article-title":"Links between complement activation and thrombosis","volume":"134","author":"Ruf","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.arth.2022.08.028_bib34","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ijsu.2018.02.043","article-title":"The efficacy of dexamethasone reducing postoperative pain and emesis after total knee arthroplasty: a systematic review and meta-analysis","volume":"52","author":"Fan","year":"2018","journal-title":"Int J Surg"}],"container-title":["The Journal of Arthroplasty"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540322007859?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540322007859?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:42:28Z","timestamp":1760121748000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883540322007859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S0883540322007859"],"URL":"https:\/\/doi.org\/10.1016\/j.arth.2022.08.028","relation":{},"ISSN":["0883-5403"],"issn-type":[{"value":"0883-5403","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is Intraoperative Dexamethasone Utilization Associated With Increased Rates of Periprosthetic Joint Infection Following Total Joint Arthroplasty?","name":"articletitle","label":"Article Title"},{"value":"The Journal of Arthroplasty","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arth.2022.08.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}