{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:24:59Z","timestamp":1792621499704,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","arthroplastyjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Arthroplasty"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.arth.2023.11.012","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T20:37:05Z","timestamp":1699994225000},"page":"1374-1383.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Safety of Early Surgery in Hip Fracture Patients Taking Clopidogrel and\/or Aspirin: A Systematic Review and Meta-Analysis"],"prefix":"10.1016","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6224-2249","authenticated-orcid":false,"given":"Wenhao","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Keon","family":"Yon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5632-5208","authenticated-orcid":false,"given":"Seung Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Koyanagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Il","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4792-027X","authenticated-orcid":false,"given":"Masoud","family":"Rahmati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfeng","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arth.2023.11.012_bib1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/BF01623184","article-title":"Hip fractures in the elderly: a world-wide projection","volume":"2","author":"Cooper","year":"1992","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.arth.2023.11.012_bib2","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/joim.12586","article-title":"Excess mortality after hip fracture in elderly persons from Europe and the USA: the CHANCES project","volume":"281","author":"Katsoulis","year":"2017","journal-title":"J\u00a0Intern Med"},{"key":"10.1016\/j.arth.2023.11.012_bib3","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.35856","article-title":"Association of multimorbidity and excess mortality after fractures among Danish adults","volume":"5","author":"Tran","year":"2022","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.arth.2023.11.012_bib4","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1007\/s00198-016-3616-5","article-title":"Hip fracture, mortality risk, and cause of death over two decades","volume":"27","author":"von Friesendorff","year":"2016","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.arth.2023.11.012_bib5","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1056\/NEJMoa2017815","article-title":"Aspirin with or without clopidogrel after transcatheter aortic-valve implantation","volume":"383","author":"Brouwer","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.arth.2023.11.012_bib6","doi-asserted-by":"crossref","first-page":"E205","DOI":"10.1503\/cmaj.202863","article-title":"A\u00a0practical approach to prescribing antiplatelet therapy in patients with acute coronary syndromes","volume":"194","author":"Alkhalil","year":"2022","journal-title":"CMAJ"},{"key":"10.1016\/j.arth.2023.11.012_bib7","first-page":"248","article-title":"A\u00a0prospective audit of blood loss and blood transfusion in patients undergoing coronary artery bypass grafting after clopidogrel and aspirin therapy. Critical care and resuscitation","volume":"6","author":"Dempsey","year":"2004","journal-title":"Crit Care Resusc"},{"key":"10.1016\/j.arth.2023.11.012_bib8","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1111\/jth.14276","article-title":"Antithrombotic therapy management of adult and pediatric cardiac surgery patients","volume":"16","author":"Baumann Kreuziger","year":"2018","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.arth.2023.11.012_bib9","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1007\/s11999-012-2306-7","article-title":"Perioperative clopidogrel and postoperative events after hip and knee arthroplasties","volume":"470","author":"Nandi","year":"2012","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2023.11.012_bib10","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.arth.2013.06.008","article-title":"Continuing clopidogrel during elective total hip and knee arthroplasty: assessment of bleeding risk and adverse outcomes","volume":"29","author":"Jacob","year":"2014","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.arth.2023.11.012_bib11","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1056\/NEJMra1206531","article-title":"Management of antithrombotic therapy in patients undergoing invasive procedures","volume":"368","author":"Baron","year":"2013","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.arth.2023.11.012_bib12","first-page":"e1291","article-title":"AAOS clinical practice guideline summary: management of hip fractures in older adults","volume":"30","author":"O'Connor","year":"2022","journal-title":"J\u00a0Am Acad Orthop Surg"},{"key":"10.1016\/j.arth.2023.11.012_bib13","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/S0140-6736(20)30058-1","article-title":"Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial","volume":"395","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.arth.2023.11.012_bib14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/anae.15291","article-title":"Guideline for the management of hip fractures 2020: guideline by the association of anaesthetists","volume":"76","author":"Griffiths","year":"2021","journal-title":"Anaesthesia"},{"key":"10.1016\/j.arth.2023.11.012_bib15","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.arth.2023.11.012_bib16","doi-asserted-by":"crossref","DOI":"10.54724\/lc.2022.e9","article-title":"PRISMA 2020 statement and guidelines for systematic review and meta-analysis articles, and their underlying mathematics: life Cycle Committee Recommendations","volume":"2","author":"Lee","year":"2022","journal-title":"Life Cycle"},{"key":"10.1016\/j.arth.2023.11.012_bib17","article-title":"Amstar 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both","volume":"358","author":"Shea","year":"2017","journal-title":"BMJ"},{"key":"10.1016\/j.arth.2023.11.012_bib18","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1111\/os.13143","article-title":"Evaluation of clopidogrel safety in geriatric patients with hip fracture: a retrospective study","volume":"13","author":"Zheng","year":"2021","journal-title":"Orthop Surg"},{"key":"10.1016\/j.arth.2023.11.012_bib19","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1097\/CM9.0000000000001668","article-title":"Safety of early surgery for geriatric hip fracture patients taking clopidogrel: a retrospective case-control study of 120 patients in China","volume":"134","author":"Yang","year":"2021","journal-title":"Chin Med J"},{"key":"10.1016\/j.arth.2023.11.012_bib20","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00264-021-04941-6","article-title":"Retrospective high volume comparative study suggests that patients on aspirin could have immediate surgery for hip fractures without significant blood loss","volume":"45","author":"Ohmori","year":"2021","journal-title":"Int Orthop"},{"key":"10.1016\/j.arth.2023.11.012_bib21","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.injury.2020.12.036","article-title":"Pre-injury use of antiplatelet and anticoagulations therapy are associated with increased mortality in a cohort of 1038 hip fracture patients","volume":"52","author":"Mahmood","year":"2021","journal-title":"Injury"},{"key":"10.1016\/j.arth.2023.11.012_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/app10238617","article-title":"Platelet aggregation inhibitors and anticoagulants delay surgery for hip fractures","volume":"10","author":"Suciu","year":"2020","journal-title":"Appl Sci"},{"key":"10.1016\/j.arth.2023.11.012_bib23","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12891-019-2504-5","article-title":"Perioperative antiplatelet in elderly patients aged over 70years treated with proximal femur fracture: continue or discontinue?","volume":"20","author":"Jang","year":"2019","journal-title":"BMC Muscoskel Disord"},{"key":"10.1016\/j.arth.2023.11.012_bib24","article-title":"Poor prognosis after surgery for intertrochanteric fracture in elderly patients with clopidogrel treatment: a cohort study","volume":"96","author":"Zhang","year":"2017","journal-title":"Medicine (Baltim)"},{"key":"10.1016\/j.arth.2023.11.012_bib25","first-page":"249","article-title":"Early surgery is feasible in patients with hip fractures who are on clopidogrel therapy","volume":"49","author":"Zehir","year":"2015","journal-title":"Acta Orthop Traumatol Turc"},{"key":"10.1016\/j.arth.2023.11.012_bib26","first-page":"29","article-title":"Effects of anticoagulants on outcome of femoral neck fracture surgery","volume":"23","author":"Ginsel","year":"2015","journal-title":"J\u00a0Orthop Surg"},{"key":"10.1016\/j.arth.2023.11.012_bib27","first-page":"95","article-title":"Operative treatment of hip fractures in patients on clopidogrel: a case-control study","volume":"32","author":"Wallace","year":"2012","journal-title":"Iowa Orthop J"},{"key":"10.1016\/j.arth.2023.11.012_bib28","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1097\/BOT.0b013e318240d70f","article-title":"The effects of clopidogrel (Plavix) and other oral anticoagulants on early hip fracture surgery","volume":"26","author":"Collinge","year":"2012","journal-title":"J\u00a0Orthop Trauma"},{"key":"10.1016\/j.arth.2023.11.012_bib29","first-page":"245","article-title":"Bleeding and first-year mortality following hip fracture surgery and preoperative use of low-dose acetylsalicylic acid: an observational cohort study","volume":"12","author":"Kragh","year":"2011","journal-title":"BMC Muscoskel Disord"},{"key":"10.1016\/j.arth.2023.11.012_bib30","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.injury.2011.01.011","article-title":"The effect of clopidogrel and aspirin on blood loss in hip fracture surgery","volume":"42","author":"Chechik","year":"2011","journal-title":"Injury"},{"key":"10.1016\/j.arth.2023.11.012_bib31","first-page":"1217","article-title":"Platelet aggregation inhibitors, platelet function testing, and blood loss in hip fracture surgery","volume":"69","author":"Thaler","year":"2010","journal-title":"J\u00a0Trauma"},{"key":"10.1016\/j.arth.2023.11.012_bib32","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1741-6612.2009.00377.x","article-title":"The management of patients with hip fractures who are taking Clopidogrel","volume":"28","author":"Sim","year":"2009","journal-title":"Australas J Ageing"},{"key":"10.1016\/j.arth.2023.11.012_bib33","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.injury.2008.03.018","article-title":"Clopidogrel therapy-Implications for hip fracture surgery","volume":"39","author":"Johansen","year":"2008","journal-title":"Injury"},{"key":"10.1016\/j.arth.2023.11.012_bib34","first-page":"29","article-title":"The association between aspirin and blood loss in hip fracture patients","volume":"72","author":"Kennedy","year":"2006","journal-title":"Acta Orthop Belg"},{"key":"10.1016\/j.arth.2023.11.012_bib35","doi-asserted-by":"crossref","first-page":"970","DOI":"10.5312\/wjo.v6.i11.970","article-title":"Effect of early surgery in high surgical risk geriatric patients with femoral neck fracture and taking antiplatelet agents","volume":"6","author":"Sa-Ngasoongsong","year":"2015","journal-title":"World J Orthop"},{"key":"10.1016\/j.arth.2023.11.012_bib36","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00068-008-8093-x","article-title":"Clopidogrel and proximal femoral fractures: does timing of surgery affect blood loss and length of admission? A preliminary study prior to multicenter trial","volume":"35","author":"Cox","year":"2009","journal-title":"Eur J Trauma Emerg Surg"},{"key":"10.1016\/j.arth.2023.11.012_bib37","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/00003086-200401000-00034","article-title":"Aspirin therapy and bleeding during proximal femoral fracture surgery","author":"Anekstein","year":"2004","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2023.11.012_bib38","doi-asserted-by":"crossref","first-page":"745","DOI":"10.2165\/00003495-199754050-00006","article-title":"Clopidogrel","volume":"54","author":"Coukell","year":"1997","journal-title":"Drugs"},{"key":"10.1016\/j.arth.2023.11.012_bib39","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1056\/NEJM200206063462309","article-title":"Cost effectiveness of aspirin, clopidogrel, or both for secondary prevention of coronary heart disease","volume":"346","author":"Gaspoz","year":"2002","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.arth.2023.11.012_bib40","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1097\/EJA.0b013e328335b354","article-title":"Platelet function recovery after cessation of aspirin: preliminary study of volunteers and surgical patients","volume":"27","author":"Zisman","year":"2010","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.arth.2023.11.012_bib41","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1302\/2058-5241.5.190071","article-title":"Proximal femur fractures in patients taking anticoagulants","volume":"5","author":"Papachristos","year":"2020","journal-title":"EFORT Open Rev"},{"key":"10.1016\/j.arth.2023.11.012_bib42","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1136\/bmj.38643.663843.55","article-title":"Effect of comorbidities and postoperative complications on mortality after hip fracture in elderly people: prospective observational cohort study","volume":"331","author":"Roche","year":"2005","journal-title":"BMJ"},{"key":"10.1016\/j.arth.2023.11.012_bib43","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s13018-020-01624-7","article-title":"Is hip fracture surgery safe for patients on antiplatelet drugs and is it necessary to delay surgery? A systematic review and meta-analysis","volume":"15","author":"Yang","year":"2020","journal-title":"J\u00a0Orthop Surg Res"},{"key":"10.1016\/j.arth.2023.11.012_bib44","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s12891-016-0988-9","article-title":"Clopidogrel and hip fractures, is it safe? A systematic review and meta-analysis","volume":"17","author":"Soo","year":"2016","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.arth.2023.11.012_bib45","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0020-1383(03)00073-1","article-title":"The effect of aspirin on blood loss and transfusion requirements in patients with femoral neck fractures","volume":"35","author":"Manning","year":"2004","journal-title":"Injury"},{"key":"10.1016\/j.arth.2023.11.012_bib46","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.injury.2012.11.028","article-title":"Clopidogrel has no effect on mortality from hip fracture","volume":"44","author":"Wordsworth","year":"2013","journal-title":"Injury"},{"key":"10.1016\/j.arth.2023.11.012_bib47","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1093\/bja\/aer288","article-title":"Perioperative management of clopidogrel therapy: the effects on in-hospital cardiac morbidity in older patients with hip fractures","volume":"107","author":"Collyer","year":"2011","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.arth.2023.11.012_bib48","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1001\/jama.2017.17606","article-title":"Association between wait time and 30-day mortality in adults undergoing hip fracture surgery","volume":"318","author":"Pincus","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.arth.2023.11.012_bib49","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1080\/17453674.2016.1195662","article-title":"Temporal trends in the use of antithrombotics at admission","volume":"87","author":"Madsen","year":"2016","journal-title":"Acta Orthop"},{"key":"10.1016\/j.arth.2023.11.012_bib50","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/BOT.0000000000001779","article-title":"Dual antiplatelet therapy and surgical timing in geriatric hip fracture","volume":"34","author":"Tarrant","year":"2020","journal-title":"J\u00a0Orthop Trauma"}],"container-title":["The Journal of Arthroplasty"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088354032301135X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088354032301135X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T10:20:49Z","timestamp":1729160449000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S088354032301135X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S088354032301135X"],"URL":"https:\/\/doi.org\/10.1016\/j.arth.2023.11.012","relation":{},"ISSN":["0883-5403"],"issn-type":[{"value":"0883-5403","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety of Early Surgery in Hip Fracture Patients Taking Clopidogrel and\/or Aspirin: A Systematic Review and Meta-Analysis","name":"articletitle","label":"Article Title"},{"value":"The Journal of Arthroplasty","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arth.2023.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}