{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T03:42:35Z","timestamp":1784000555140,"version":"3.55.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR082167"],"award-info":[{"award-number":["R01 AR082167"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03 AR077602"],"award-info":[{"award-number":["R03 AR077602"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1 TR001857"],"award-info":[{"award-number":["UL1 TR001857"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["arthroplastyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Arthroplasty"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.arth.2024.08.048","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T18:39:05Z","timestamp":1731436745000},"page":"S502-S506","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"S1","title":["Treatment Failure Rates Significantly Decrease at One and Five Years After Debridement, Antibiotics, and Implant Retention for Acute Periprosthetic Joint Infection in Total Knee Arthroplasty: A 10 Year Cohort Study"],"prefix":"10.1016","volume":"40","author":[{"given":"Richard","family":"Chao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Rothenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes F.","family":"Plate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Klatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neel B.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9128-5683","authenticated-orcid":false,"given":"Kenneth L.","family":"Urish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arth.2024.08.048_bib1","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1007\/s11999-017-5396-4","article-title":"Periprosthetic joint infection is the main cause of failure for modern knee arthroplasty: an analysis of 11,134 knees","volume":"475","author":"Koh","year":"2017","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2024.08.048_bib2","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1016\/j.arth.2018.08.021","article-title":"Mortality during total knee periprosthetic joint infection","volume":"33","author":"Lum","year":"2018","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2024.08.048_bib3","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.1016\/j.arth.2018.05.042","article-title":"Are we winning or losing the battle with Periprosthetic Joint Infection: trends in periprosthetic joint infection and mortality risk for the Medicare population","volume":"33","author":"Kurtz","year":"2018","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2024.08.048_bib4","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.3899\/jrheum.170990","article-title":"Rates of total joint replacement in the United States: future projections to 2020\u20132040 using the National Inpatient Sample","volume":"46","author":"Singh","year":"2019","journal-title":"J Rheumatol"},{"key":"10.1016\/j.arth.2024.08.048_bib5","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.arth.2022.03.046","article-title":"High mortality after total knee arthroplasty periprosthetic joint infection is related to preoperative morbidity and the disease process but not treatment","volume":"37","author":"Drain","year":"2022","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2024.08.048_bib6","first-page":"151","article-title":"Current concepts on the clinical and economic impact of periprosthetic joint infections","volume":"55","author":"Sadhwani","year":"2023","journal-title":"Orthop Clin"},{"key":"10.1016\/j.arth.2024.08.048_bib7","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s42836-020-00056-2","article-title":"Risk factors affect success rate of debridement, antibiotics and implant retention (DAIR) in periprosthetic joint infection","volume":"2","author":"Xu","year":"2020","journal-title":"Arthroplasty"},{"key":"10.1016\/j.arth.2024.08.048_bib8","doi-asserted-by":"crossref","first-page":"667","DOI":"10.5312\/wjo.v5.i5.667","article-title":"Treatment of acute periprosthetic infections with prosthesis retention: review of current concepts","volume":"5","author":"Kuiper","year":"2014","journal-title":"World J Orthop"},{"key":"10.1016\/j.arth.2024.08.048_bib9","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.arth.2017.11.029","article-title":"A multicenter study of irrigation and debridement in total knee arthroplasty periprosthetic joint infection: treatment failure is high","volume":"33","author":"Urish","year":"2018","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2024.08.048_bib10","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.arth.2020.07.081","article-title":"Success rates of debridement, antibiotics, and implant retention in 230 infected total knee arthroplasties: implications for classification of periprosthetic joint infection","volume":"36","author":"Zhu","year":"2021","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2024.08.048_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13018-019-1324-5","article-title":"DAIR (Debridement, Antibiotics and Implant Retention) less effective in hematogenous total knee arthroplasty infections","volume":"14","author":"Iza","year":"2019","journal-title":"J Orthop Surg Res"},{"key":"10.1016\/j.arth.2024.08.048_bib12","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1093\/cid\/cis746","article-title":"A large multicenter study of methicillin\u2013susceptible and methicillin\u2013resistant Staphylococcus aureus prosthetic joint infections managed with implant retention","volume":"56","author":"Lora-Tamayo","year":"2013","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.arth.2024.08.048_bib13","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/cid\/ciz261","article-title":"Benefits and adverse events associated with extended antibiotic use in total knee arthroplasty periprosthetic joint infection","volume":"70","author":"Shah","year":"2020","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.arth.2024.08.048_bib14","first-page":"93","article-title":"Clinical evidence of current irrigation practices and the use of oral antibiotics to prevent and treat periprosthetic joint infection","volume":"52","author":"Zlotnicki","year":"2021","journal-title":"Orthop Clin"},{"key":"10.1016\/j.arth.2024.08.048_bib15","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1056\/NEJMoa1710926","article-title":"Oral versus intravenous antibiotics for bone and joint infection","volume":"380","author":"Li","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.arth.2024.08.048_bib16","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1302\/0301-620X.100B11.BJJ-2018-0515.R1","article-title":"Irrigation and debridement with chronic antibiotic suppression for the management of infected total knee arthroplasty: a Contemporary Analysis","volume":"100-B","author":"Weston","year":"2018","journal-title":"Bone Joint J"},{"key":"10.1016\/j.arth.2024.08.048_bib17","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.2106\/JBJS.N.00999","article-title":"Chronic suppression of periprosthetic joint infections with oral antibiotics increases infection-free survivorship","volume":"97","author":"Siqueira","year":"2015","journal-title":"J Bone Joint Surg"},{"key":"10.1016\/j.arth.2024.08.048_bib18","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1016\/j.arth.2021.01.051","article-title":"The AAHKS clinical research award: extended oral antibiotics prevent periprosthetic joint infection in high-risk cases: 3855 patients with 1-year follow-up","volume":"36","author":"Kheir","year":"2021","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2024.08.048_bib19","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1007\/s11999-016-4720-8","article-title":"Antibiotic-tolerant Staphylococcus aureus biofilm persists on arthroplasty materials","volume":"474","author":"Urish","year":"2016","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2024.08.048_bib20","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3390\/life10110253","article-title":"Staphylococcus epidermidis biofilms have a high tolerance to antibiotics in periprosthetic joint infection","volume":"10","author":"Koch","year":"2020","journal-title":"Life"},{"key":"10.1016\/j.arth.2024.08.048_bib21","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1002\/jor.24291","article-title":"Large variations in clinical antibiotic activity against Staphylococcus aureus biofilms of periprosthetic joint infection isolates","volume":"37","author":"Mandell","year":"2019","journal-title":"J Orthop Res"},{"key":"10.1016\/j.arth.2024.08.048_bib22","doi-asserted-by":"crossref","first-page":"241","DOI":"10.5194\/jbji-6-241-2021","article-title":"The Staphylococcus aureus toxin\u2013antitoxin system YefM\u2013YoeB is associated with antibiotic tolerance and extracellular dependent biofilm formation","volume":"6","author":"Qi","year":"2021","journal-title":"J Bone Jt Infec"},{"key":"10.1016\/j.arth.2024.08.048_bib23","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01658-19","article-title":"The toxin-antitoxin MazEF drives Staphylococcus aureus biofilm formation, antibiotic tolerance, and chronic infection","volume":"10","author":"Ma","year":"2019","journal-title":"mBio"},{"key":"10.1016\/j.arth.2024.08.048_bib24","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.arth.2013.12.012","article-title":"Pulse lavage is inadequate at removal of biofilm from the surface of total knee arthroplasty materials","volume":"29","author":"Urish","year":"2014","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2024.08.048_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17780-6","article-title":"Elimination of antibiotic resistant surgical implant biofilms using an engineered cationic amphipathic peptide WLBU2","volume":"7","author":"Mandell","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.arth.2024.08.048_bib26","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.1038\/s41598-023-30951-y","article-title":"Dose optimization in surgical prophylaxis: sub-inhibitory dosing of vancomycin increases rates of biofilm formation and the rates of surgical site infection","volume":"13","author":"Brothers","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.arth.2024.08.048_bib27","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1016\/j.arth.2020.02.017","article-title":"Reporting outcomes of treatment for periprosthetic joint infection of the knee and hip together with a minimum 1-year follow-up is reliable","volume":"35","author":"Xu","year":"2020","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2024.08.048_bib28","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/cis803","article-title":"Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America","volume":"56","author":"Osmon","year":"2013","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.arth.2024.08.048_bib29","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1214\/aoms\/1177728174","article-title":"Asymptotic minimax character of the sample distribution function and of the classical multinomial estimator","author":"Dvoretzky","year":"1956","journal-title":"Ann Math Stat"},{"key":"10.1016\/j.arth.2024.08.048_bib30","first-page":"1269","article-title":"The tight constant in the Dvoretzky-Kiefer-Wolfowitz inequality","author":"Massart","year":"1990","journal-title":"Ann Probab"},{"key":"10.1016\/j.arth.2024.08.048_bib37","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.3390\/life13061230","article-title":"Hydrogen peroxide, povidone-iodine and chlorhexidine fail to eradicate Staphylococcus aureus biofilm from infected implant materials","volume":"13","author":"Parker","year":"2023","journal-title":"Life"},{"key":"10.1016\/j.arth.2024.08.048_bib32","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.arth.2017.11.024","article-title":"Cementless one-stage revision in chronic periprosthetic hip joint infection. Ninety-one percent infection free survival in 56 patients at minimum 2-year follow-up","volume":"33","author":"Lange","year":"2018","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2024.08.048_bib33","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00402-021-04265-5","article-title":"Predictors of failure of two-stage revision in periprosthetic knee infection: a retrospective cohort study with a minimum two-year follow-up","volume":"142","author":"Russo","year":"2022","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/j.arth.2024.08.048_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.artd.2022.10.007","article-title":"The paradox of the decline of cemented femoral stems","volume":"19","author":"Dujardin","year":"2023","journal-title":"Arthroplast Today"}],"container-title":["The Journal of Arthroplasty"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540324009112?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540324009112?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T00:29:16Z","timestamp":1755995356000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883540324009112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S0883540324009112"],"URL":"https:\/\/doi.org\/10.1016\/j.arth.2024.08.048","relation":{},"ISSN":["0883-5403"],"issn-type":[{"value":"0883-5403","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment Failure Rates Significantly Decrease at One and Five Years After Debridement, Antibiotics, and Implant Retention for Acute Periprosthetic Joint Infection in Total Knee Arthroplasty: A 10 Year Cohort Study","name":"articletitle","label":"Article Title"},{"value":"The Journal of Arthroplasty","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arth.2024.08.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}