{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:47:20Z","timestamp":1790858840573,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["arthroplastyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Arthroplasty"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.arth.2025.08.002","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T15:13:24Z","timestamp":1754579604000},"page":"551-559","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Novel Technologies in Periprosthetic Joint Infection: Emerging Diagnostics"],"prefix":"10.1016","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4546-0719","authenticated-orcid":false,"given":"Matthew L.","family":"Magruder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathanael D.","family":"Heckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay R.","family":"Lieberman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giles R.","family":"Scuderi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Lustig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javad","family":"Parvizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Mont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arth.2025.08.002_bib1","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1016\/j.arth.2018.08.021","article-title":"Mortality during total knee periprosthetic joint infection","volume":"33","author":"Lum","year":"2018","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.08.002_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.arth.2018.12.024","article-title":"Mortality during total hip periprosthetic joint infection","volume":"34","author":"Natsuhara","year":"2019","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.08.002_bib3","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1055\/s-0041-1735282","article-title":"The epidemiology of revision total knee arthroplasty","volume":"34","author":"Tarazi","year":"2021","journal-title":"J Knee Surg"},{"key":"10.1016\/j.arth.2025.08.002_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.artd.2024.101325","article-title":"Highlights of the 2023 American joint replacement registry annual report","volume":"26","author":"Ryan","year":"2024","journal-title":"Arthroplast Today"},{"key":"10.1016\/j.arth.2025.08.002_bib5","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.arth.2020.12.005","article-title":"Projected economic burden of periprosthetic joint infection of the hip and knee in the United States","volume":"36","author":"Premkumar","year":"2021","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.08.002_bib6","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.arth.2018.02.078","article-title":"The 2018 definition of periprosthetic hip and knee infection: an evidence-based and validated criteria","volume":"33","author":"Parvizi","year":"2018","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.08.002_bib7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s13018-019-1185-y","article-title":"The 2018 new definition of periprosthetic joint infection improves the diagnostic efficiency in the Chinese population","volume":"14","author":"Guan","year":"2019","journal-title":"J Orthop Surg Res"},{"key":"10.1016\/j.arth.2025.08.002_bib8","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.arth.2020.07.023","article-title":"The 2018 new definition of periprosthetic joint infection is valuable for diagnosis of persistent infection at reimplantation in patients without synovial fluid","volume":"36","author":"Jiang","year":"2021","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.08.002_bib9","article-title":"Culture-negative periprosthetic joint infection: an update on what to expect","volume":"3","author":"Tan","year":"2018","journal-title":"JB JS Open Access"},{"key":"10.1016\/j.arth.2025.08.002_bib10","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1302\/2046-3758.119.BJR-2022-0078.R1","article-title":"Diagnosing periprosthetic joint infections : a comparison of infection definitions: EBJIS 2021, ICM 2018, and IDSA 2013","volume":"11","author":"Sigmund","year":"2022","journal-title":"Bone Joint Res"},{"key":"10.1016\/j.arth.2025.08.002_bib11","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1302\/0301-620X.103B1.BJJ-2020-0017.R3","article-title":"Next-generation sequencing not superior to culture in periprosthetic joint infection diagnosis","volume":"103-b","author":"Kildow","year":"2021","journal-title":"Bone Joint J"},{"key":"10.1016\/j.arth.2025.08.002_bib12","doi-asserted-by":"crossref","DOI":"10.7754\/Clin.Lab.2022.220833","article-title":"A meta-analysis of polymerase chain reaction for prosthetic joint infection diagnosis","volume":"69","author":"Lee","year":"2023","journal-title":"Clin Lab"},{"key":"10.1016\/j.arth.2025.08.002_bib13","doi-asserted-by":"crossref","DOI":"10.1128\/jcm.01126-22","article-title":"Comparison of the BioFire joint infection panel to 16S ribosomal RNA gene-based targeted metagenomic sequencing for testing synovial fluid from patients with knee arthroplasty failure","volume":"60","author":"Azad","year":"2022","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.arth.2025.08.002_bib14","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1302\/2058-5241.6.200118","article-title":"An update about molecular biology techniques to detect orthopaedic implant-related infections","volume":"6","author":"Esteban","year":"2021","journal-title":"EFORT Open Rev"},{"key":"10.1016\/j.arth.2025.08.002_bib15","doi-asserted-by":"crossref","DOI":"10.1021\/jp040125g","article-title":"Metal-capped brownian and magnetically modulated optical nanoprobes (MOONs): micromechanics in chemical and biological microenvironments","volume":"108","author":"Behrend","year":"2004","journal-title":"The J Phys Chem B"},{"key":"10.1016\/j.arth.2025.08.002_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202104124","article-title":"Synovial fluid pH sensor for early detection of prosthetic hip infections","volume":"31","author":"Wijayaratna","year":"2021","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.arth.2025.08.002_bib17","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1039\/C8AN02337A","article-title":"An implanted pH sensor read using radiography","volume":"144","author":"Arifuzzaman","year":"2019","journal-title":"Analyst"},{"key":"10.1016\/j.arth.2025.08.002_bib18","article-title":"X-ray excited luminescent chemical imaging (XELCI) for non-invasive imaging of implant infections","volume":"10081","author":"Benza","year":"2017","journal-title":"Proc SPIE Int Soc Opt Eng"},{"key":"10.1016\/j.arth.2025.08.002_bib19","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1002\/adhm.201400685","article-title":"X-Ray excited luminescence chemical imaging of bacterial growth on surfaces implanted in tissue","volume":"4","author":"Wang","year":"2015","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.arth.2025.08.002_bib20","series-title":"X-ray Visualized Immunosensor (X-VIS)","author":"Anker","year":"2024"},{"key":"10.1016\/j.arth.2025.08.002_bib21","article-title":"Urinary fatty acid biomarkers for prostate cancer detection","volume":"19","author":"Noriega","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.arth.2025.08.002_bib22","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.humimm.2018.01.006","article-title":"Urine biomarkers informative of human kidney allograft rejection and tolerance","volume":"79","author":"Nissaisorakarn","year":"2018","journal-title":"Hum Immunol"},{"key":"10.1016\/j.arth.2025.08.002_bib23","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3390\/cancers14020461","article-title":"A novel urinary miRNA biomarker for early detection of colorectal cancer","volume":"14","author":"Iwasaki","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.arth.2025.08.002_bib24","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1007\/s10388-022-00932-7","article-title":"Urinary protein biomarker panel predicts esophageal squamous carcinoma from control cases and other tumors","volume":"19","author":"Ji","year":"2022","journal-title":"Esophagus"},{"key":"10.1016\/j.arth.2025.08.002_bib25","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1186\/2193-1801-3-561","article-title":"Endoglin (CD105) expression differentiates between aseptic loosening and periprosthetic joint infection after total joint arthroplasty","volume":"3","author":"Jansen","year":"2014","journal-title":"Springerplus"},{"key":"10.1016\/j.arth.2025.08.002_bib26","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.arth.2016.06.036","article-title":"Transcriptome-wide high-density microarray analysis reveals differential gene transcription in periprosthetic tissue from hips with chronic periprosthetic joint infection vs aseptic loosening","volume":"32","author":"Omar","year":"2017","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.08.002_bib27","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/jor.24913","article-title":"Noninvasive diagnostic of periprosthetic joint infection by urinary peptide markers: a preliminary study","volume":"39","author":"Omar","year":"2021","journal-title":"J Orthop Res"},{"key":"10.1016\/j.arth.2025.08.002_bib28","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1007\/s11999-014-3543-8","article-title":"Diagnosing periprosthetic joint infection: has the era of the biomarker arrived?","volume":"472","author":"Deirmengian","year":"2014","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2025.08.002_bib29","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.arth.2011.03.025","article-title":"Molecular markers for diagnosis of periprosthetic joint infection","volume":"26","author":"Jacovides","year":"2011","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.08.002_bib30","doi-asserted-by":"crossref","DOI":"10.1128\/jcm.02196-21","article-title":"Enhancing diagnostics in orthopedic infections","volume":"60","author":"Higgins","year":"2022","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.arth.2025.08.002_bib31","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1128\/JCM.00570-14","article-title":"Detection of prosthetic joint infection by use of PCR-electrospray ionization mass spectrometry applied to synovial fluid","volume":"52","author":"Melendez","year":"2014","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.arth.2025.08.002_bib32","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1128\/JCM.02302-15","article-title":"Evaluation of a Genus- and group-specific rapid PCR assay panel on synovial fluid for diagnosis of prosthetic knee infection","volume":"54","author":"Melendez","year":"2016","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.arth.2025.08.002_bib33","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1016\/j.arth.2019.02.044","article-title":"Performance of sequencing assays in diagnosis of prosthetic joint infection: a systematic review and meta-analysis","volume":"34","author":"Li","year":"2019","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.08.002_bib34","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3390\/antibiotics12020296","article-title":"Profiling the immune response to periprosthetic joint infection and non-infectious arthroplasty failure","volume":"12","author":"Fisher","year":"2023","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.arth.2025.08.002_bib35","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1189\/jlb.3VMA1014-482R","article-title":"Neutrophil-derived MRP-14 is up-regulated in infectious osteomyelitis and stimulates osteoclast generation","volume":"98","author":"Dapunt","year":"2015","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.arth.2025.08.002_bib36","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/728619","article-title":"The macrophage inflammatory proteins MIP1\u03b1 (CCL3) and MIP2\u03b1 (CXCL2) in implant-associated osteomyelitis: linking inflammation to bone degradation","volume":"2014","author":"Dapunt","year":"2014","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.arth.2025.08.002_bib37","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1186\/s12891-016-1091-y","article-title":"The osteoblast as an inflammatory cell: production of cytokines in response to bacteria and components of bacterial biofilms","volume":"17","author":"Dapunt","year":"2016","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.arth.2025.08.002_bib38","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1002\/jor.24766","article-title":"Comparative analysis of 23 synovial fluid biomarkers for hip and knee periprosthetic joint infection detection","volume":"38","author":"Sharma","year":"2020","journal-title":"J Orthop Res"},{"key":"10.1016\/j.arth.2025.08.002_bib39","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1093\/nar\/gkae267","article-title":"Fourteen years of cellular deconvolution: methodology, applications, technical evaluation and outstanding challenges","volume":"52","author":"Nguyen","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.arth.2025.08.002_bib40","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2106\/JBJS.22.00605","article-title":"Sonicate fluid cellularity predicted by transcriptomic deconvolution differentiates infectious from non-infectious arthroplasty failure","volume":"105","author":"Fisher","year":"2023","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2025.08.002_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines8090358","article-title":"High-dimensional analysis of immune cell composition predicts periprosthetic joint infections and dissects its pathophysiology","volume":"8","author":"Korn","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.arth.2025.08.002_bib42","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.4049\/jimmunol.1402689","article-title":"IL-12 promotes myeloid-derived suppressor cell recruitment and bacterial persistence during Staphylococcus aureus orthopedic implant infection","volume":"194","author":"Heim","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.arth.2025.08.002_bib43","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jor.23806","article-title":"Human prosthetic joint infections are associated with myeloid-derived suppressor cells (MDSCs): implications for infection persistence","volume":"36","author":"Heim","year":"2018","journal-title":"J Orthop Res"},{"key":"10.1016\/j.arth.2025.08.002_bib44","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.3390\/genes12071098","article-title":"The trifecta of single-cell, systems-biology, and machine-learning approaches","volume":"12","author":"Weiskittel","year":"2021","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.arth.2025.08.002_bib45","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13073-017-0467-4","article-title":"A practical guide to single-cell RNA-sequencing for biomedical research and clinical applications","volume":"9","author":"Haque","year":"2017","journal-title":"Genome Med"},{"key":"10.1016\/j.arth.2025.08.002_bib46","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1186\/s12967-024-05866-5","article-title":"The mononuclear phagocyte system obscures the accurate diagnosis of infected joint replacements","volume":"22","author":"Manasherob","year":"2024","journal-title":"J Transl Med"},{"key":"10.1016\/j.arth.2025.08.002_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-20444-9","article-title":"A 92 protein inflammation panel performed on sonicate fluid differentiates periprosthetic joint infection from non-infectious causes of arthroplasty failure","volume":"12","author":"Fisher","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.arth.2025.08.002_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2022.146400","article-title":"Human transcriptomic response to periprosthetic joint infection","volume":"825","author":"Masters","year":"2022","journal-title":"Gene"},{"key":"10.1016\/j.arth.2025.08.002_bib49","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1302\/0301-620X.97B9.34910","article-title":"Use of leucocyte esterase reagent strips in the diagnosis or exclusion of prosthetic joint infection","volume":"97-b","author":"Shafafy","year":"2015","journal-title":"Bone Joint J"},{"key":"10.1016\/j.arth.2025.08.002_bib50","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.2106\/JBJS.J.01413","article-title":"Diagnosis of periprosthetic joint infection: the utility of a simple yet unappreciated enzyme","volume":"93","author":"Parvizi","year":"2011","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2025.08.002_bib51","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.arth.2012.03.037","article-title":"Leukocyte esterase reagent strips for the rapid diagnosis of periprosthetic joint infection","volume":"27","author":"Wetters","year":"2012","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.08.002_bib52","series-title":"Rapid Electrochemical Biosensor for Point-of-Care Diagnosis of Joint Infection","author":"Fleischman","year":"2023"},{"key":"10.1016\/j.arth.2025.08.002_bib53","doi-asserted-by":"crossref","first-page":"245","DOI":"10.33549\/physiolres.930448","article-title":"Calprotectin - a pleiotropic molecule in acute and chronic inflammation","volume":"53","author":"Str\u00edz","year":"2004","journal-title":"Physiol Res"},{"key":"10.1016\/j.arth.2025.08.002_bib54","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.3390\/jcm12031206","article-title":"Diagnostic accuracy of fecal calprotectin for predicting relapse in inflammatory bowel disease: a meta-analysis","volume":"12","author":"Shi","year":"2023","journal-title":"J Clin Med"},{"key":"10.1016\/j.arth.2025.08.002_bib55","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.arth.2019.08.052","article-title":"Synovial fluid calprotectin for the preoperative diagnosis of chronic periprosthetic joint infection","volume":"35","author":"Salari","year":"2020","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.08.002_bib56","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1302\/0301-620X.99B5.BJJ-2016-0913.R2","article-title":"Synovial calprotectin: a potential biomarker to exclude a prosthetic joint infection","volume":"99-b","author":"Wouthuyzen-Bakker","year":"2017","journal-title":"Bone Joint J"},{"key":"10.1016\/j.arth.2025.08.002_bib57","doi-asserted-by":"crossref","first-page":"741","DOI":"10.3390\/diagnostics13040741","article-title":"Evaluation of synovial calprotectin by using a lateral flow test for the diagnosis of prosthetic joint infections","volume":"13","author":"Bottagisio","year":"2023","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.arth.2025.08.002_bib58","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.arth.2022.01.082","article-title":"Calprotectin lateral flow test: consistent across criteria for ruling out periprosthetic joint infection","volume":"37","author":"Warren","year":"2022","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.08.002_bib59","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1302\/2046-3758.95.BJR-2019-0213.R1","article-title":"Preliminary evaluation of a rapid lateral flow calprotectin test for the diagnosis of prosthetic joint infection","volume":"9","author":"Trotter","year":"2020","journal-title":"Bone Joint Res"},{"key":"10.1016\/j.arth.2025.08.002_bib60","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.2106\/JBJS.20.01089","article-title":"Diagnostic utility of a novel point-of-care test of calprotectin for periprosthetic joint infection after total knee arthroplasty: a prospective cohort study","volume":"103","author":"Warren","year":"2021","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2025.08.002_bib61","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s00264-023-05691-3","article-title":"The synovial fluid calprotectin lateral flow test for the diagnosis of chronic prosthetic joint infection in failed primary and revision total hip and knee arthroplasty","volume":"47","author":"Suren","year":"2023","journal-title":"Int Orthop"},{"key":"10.1016\/j.arth.2025.08.002_bib62","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s00264-022-05357-6","article-title":"Synovial fluid calprotectin in diagnosing periprosthetic joint infection: a meta-analysis","volume":"46","author":"Hantouly","year":"2022","journal-title":"Int Orthop"},{"issue":"5 Supple B","key":"10.1016\/j.arth.2025.08.002_bib63","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1302\/0301-620X.106B5.BJJ-2023-0848.R1","article-title":"Intraoperative calprotectin lateral flow immunoassay can assist decision-making between one- and two-stage revision total hip arthroplasty for patients with suspected periprosthetic joint infection","volume":"106-b","author":"Macheras","year":"2024","journal-title":"Bone Joint J"},{"key":"10.1016\/j.arth.2025.08.002_bib64","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1007\/s00264-022-05421-1","article-title":"Synovial calprotectin is a reliable biomarker for periprosthetic joint infections in acute-phase inflammation - a prospective cohort study","volume":"46","author":"Lazic","year":"2022","journal-title":"Int Orthop"},{"key":"10.1016\/j.arth.2025.08.002_bib65","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.21873\/invivo.13258","article-title":"Synovial calprotectin for diagnosing periprosthetic joint infection in loose hip and knee arthroplasties: a prospective cohort study","volume":"37","author":"Lazic","year":"2023","journal-title":"In Vivo"},{"key":"10.1016\/j.arth.2025.08.002_bib66","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-22892-9","article-title":"Utility of synovial calprotectin lateral flow test to exclude chronic prosthetic joint infection in periprosthetic fractures: a prospective cohort study","volume":"12","author":"Lazic","year":"2022","journal-title":"Sci Rep"}],"container-title":["The Journal of Arthroplasty"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540325010071?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540325010071?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:02:01Z","timestamp":1766793721000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883540325010071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":66,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S0883540325010071"],"URL":"https:\/\/doi.org\/10.1016\/j.arth.2025.08.002","relation":{},"ISSN":["0883-5403"],"issn-type":[{"value":"0883-5403","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel Technologies in Periprosthetic Joint Infection: Emerging Diagnostics","name":"articletitle","label":"Article Title"},{"value":"The Journal of Arthroplasty","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arth.2025.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}