{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:08:01Z","timestamp":1793318881169,"version":"4.5.0"},"reference-count":108,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["arthroplastyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Arthroplasty"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.arth.2025.09.020","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T07:56:29Z","timestamp":1758614189000},"page":"1509-1517","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Management of Chronic Antithrombotic Medication in Total Joint Arthroplasty: A Primer for the Orthopaedic Surgeon"],"prefix":"10.1016","volume":"41","author":[{"given":"Theodor","family":"Di Pauli von Treuheim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0074-580X","authenticated-orcid":false,"given":"Garrett L.","family":"Ruff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Shanaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Schwarzkopf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay K.","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arth.2025.09.020_bib1","article-title":"Projections and epidemiology of primary hip and knee arthroplasty in medicare patients to 2040-2060","volume":"8","author":"Shichman","year":"2023","journal-title":"JB JS Open Access"},{"key":"10.1016\/j.arth.2025.09.020_bib2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ahj.2012.11.005","article-title":"Thrombotic and bleeding complications after orthopedic surgery","volume":"165","author":"Oberweis","year":"2013","journal-title":"Am Heart J"},{"key":"10.1016\/j.arth.2025.09.020_bib3","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.3899\/jrheum.170990","article-title":"Rates of total joint replacement in the United States: future projections to 2020\u20132040 using the national inpatient sample","volume":"46","author":"Singh","year":"2019","journal-title":"J Rheumatol"},{"key":"10.1016\/j.arth.2025.09.020_bib4","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.2106\/JBJS.17.01617","article-title":"Projected volume of primary total joint arthroplasty in the U.S., 2014 to 2030","volume":"100","author":"Sloan","year":"2018","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2025.09.020_bib5","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.otsr.2020.02.026","article-title":"Bleeding and thromboembolism risk of standard antithrombotic prophylaxis after hip or knee replacement within an enhanced recovery program","volume":"106","author":"Jenny","year":"2020","journal-title":"Orthop Traumatol Surg Res"},{"key":"10.1016\/j.arth.2025.09.020_bib6","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1016\/j.arth.2018.06.023","article-title":"The efficacy of tranexamic acid in total hip arthroplasty: a network meta-analysis","volume":"33","author":"Fillingham","year":"2018","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.09.020_bib7","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1016\/j.arth.2018.08.002","volume":"33","author":"Fillingham","year":"2018","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.09.020_bib8","doi-asserted-by":"crossref","first-page":"180","DOI":"10.2106\/JBJS.21.01529","article-title":"Recommendations from the ICM-VTE: hip & knee","volume":"104","author":"Delegates\u2217 TI-VH&","year":"2022","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2025.09.020_bib9","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.arth.2019.09.043","article-title":"Low-dose aspirin is adequate for venous thromboembolism prevention following total joint arthroplasty: a systematic review","volume":"35","author":"Azboy","year":"2020","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.09.020_bib10","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1016\/j.arth.2021.08.018","article-title":"Who is still receiving blood transfusions after primary and revision total joint arthroplasty?","volume":"37","author":"DeMik","year":"2022","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.09.020_bib11","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.arth.2019.08.049","article-title":"Have venous thromboembolism rates decreased in total hip and knee arthroplasty?","volume":"35","author":"Warren","year":"2020","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.09.020_bib12","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1016\/j.arth.2018.03.031","article-title":"The safety of tranexamic acid in total joint arthroplasty: a direct meta-analysis","volume":"33","author":"Fillingham","year":"2018","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.09.020_bib13","doi-asserted-by":"crossref","first-page":"729","DOI":"10.5435\/00124635-201012000-00003","article-title":"Perioperative Management of Chronic Anticoagulation in Orthopaedic Surgery","volume":"18","author":"Thakur","year":"2010","journal-title":"J Am Acad Orthop Surg"},{"key":"10.1016\/j.arth.2025.09.020_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/medicina57020188","article-title":"Perioperative management of chronic antithrombotic agents in elective hip and knee arthroplasty","volume":"57","author":"Santana","year":"2021","journal-title":"Medicina"},{"key":"10.1016\/j.arth.2025.09.020_bib15","first-page":"SP309","article-title":"Direct oral anticoagulant prescription trends, switching patterns, and adherence in Texas medicaid","volume":"24","author":"Wong","year":"2018","journal-title":"Am J Manag Care"},{"key":"10.1016\/j.arth.2025.09.020_bib16","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.amjmed.2015.05.044","article-title":"National trends in ambulatory oral anticoagulant use","volume":"128","author":"Barnes","year":"2015","journal-title":"Am J Med"},{"key":"10.1016\/j.arth.2025.09.020_bib17","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/phar.2158","article-title":"Trends and variation in oral anticoagulant choice in patients with atrial fibrillation, 2010-2017","volume":"38","author":"Zhu","year":"2018","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.arth.2025.09.020_bib18","doi-asserted-by":"crossref","DOI":"10.1001\/jamahealthforum.2021.1693","article-title":"National trends in use of and spending on oral anticoagulants among US medicare beneficiaries from 2011 to 2019","volume":"2","author":"Troy","year":"2021","journal-title":"JAMA Health Forum"},{"key":"10.1016\/j.arth.2025.09.020_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajpc.2021.100256","article-title":"Aspirin for cardiovascular disease prevention among adults in the United States: trends, prevalence, and participant characteristics associated with use","volume":"8","author":"Boakye","year":"2021","journal-title":"Am J Prev Cardiol"},{"key":"10.1016\/j.arth.2025.09.020_bib20","doi-asserted-by":"crossref","first-page":"537","DOI":"10.2106\/JBJS.21.00514","article-title":"Trends of obesity rates between patients undergoing primary total knee arthroplasty and the general population from 2013 to 2020","volume":"104","author":"Muthusamy","year":"2022","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2025.09.020_bib21","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1016\/j.arth.2021.04.017","article-title":"Effects of the obesity epidemic on total hip and knee arthroplasty demographics","volume":"36","author":"Johnson","year":"2021","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.09.020_bib22","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1016\/j.arth.2024.05.081","article-title":"How has the total hip arthroplasty patient population changed? A ten-year analysis of total hip arthroplasty patients from 2013 to 2022: a retrospective, single-center study","volume":"39","author":"Ruff","year":"2024","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.09.020_bib23","doi-asserted-by":"crossref","first-page":"M468","DOI":"10.1093\/gerona\/58.5.M468","article-title":"Elective primary total hip arthroplasty in octogenarians","volume":"58","author":"Wurtz","year":"2003","journal-title":"J Gerontol Ser A"},{"key":"10.1016\/j.arth.2025.09.020_bib24","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1093\/eurheartj\/eht280","article-title":"Projections on the number of individuals with atrial fibrillation in the European union, from 2000 to 2060","volume":"34","author":"Krijthe","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.arth.2025.09.020_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0195088","article-title":"Estimated prevalence of undiagnosed atrial fibrillation in the United States","volume":"13","author":"Turakhia","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.arth.2025.09.020_bib26","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1378\/chest.09-1584","article-title":"Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation","volume":"137","author":"Lip","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.arth.2025.09.020_bib27","first-page":"e72","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: a report of the American college of cardiology\/American heart association joint committee on clinical practice guidelines","volume":"143","author":"Otto","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.arth.2025.09.020_bib28","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1182\/blood.2019002364","article-title":"Long-term treatment of venous thromboembolism","volume":"135","author":"Kearon","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.arth.2025.09.020_bib29","series-title":"GeneReviews\u00ae","article-title":"Factor V leiden thrombophilia","author":"Pastori","year":"1993"},{"key":"10.1016\/j.arth.2025.09.020_bib30","series-title":"Hypercoagulability. StatPearls, Treasure Island (FL)","author":"Senst","year":"2024"},{"key":"10.1016\/j.arth.2025.09.020_bib31","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1161\/CIR.0000000000001123","article-title":"Heart disease and stroke Statistics\u20142023 update: a report from the American heart association","volume":"147","author":"Tsao","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.arth.2025.09.020_bib32","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1001\/jama.2022.3337","article-title":"Aspirin use to prevent cardiovascular disease and colorectal cancer: updated evidence report and systematic review for the US preventive services task force","volume":"327","author":"Guirguis-Blake","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.arth.2025.09.020_bib33","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1001\/jama.2022.3385","article-title":"Aspirin use to prevent cardiovascular disease and colorectal cancer: updated modeling study for the US preventive services task force","volume":"327","author":"Dehmer","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.arth.2025.09.020_bib34","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1001\/jama.2022.4983","article-title":"Aspirin use to prevent cardiovascular disease: US preventive services task force recommendation statement","volume":"327","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.arth.2025.09.020_bib35","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.jacc.2020.07.037","article-title":"Comparative trends in percutaneous coronary intervention in Japan and the United States, 2013 to 2017","volume":"76","author":"Inohara","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.arth.2025.09.020_bib36","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1056\/NEJMoa1114238","article-title":"Aspirin for preventing the recurrence of venous thromboembolism","volume":"366","author":"Becattini","year":"2012","journal-title":"New Engl J Med"},{"key":"10.1016\/j.arth.2025.09.020_bib37","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1161\/CIRCULATIONAHA.114.008828","article-title":"Aspirin for the prevention of recurrent venous thromboembolism","volume":"130","author":"Simes","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.arth.2025.09.020_bib38","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1634\/theoncologist.2016-0214","article-title":"Cancer and venous thromboembolic disease: a review","volume":"22","author":"Donnellan","year":"2017","journal-title":"Oncologist"},{"key":"10.1016\/j.arth.2025.09.020_bib39","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1056\/NEJMra052717","article-title":"Low-dose aspirin for the prevention of atherothrombosis","volume":"353","author":"Patrono","year":"2005","journal-title":"New Engl J Med"},{"key":"10.1016\/j.arth.2025.09.020_bib40","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.jos.2022.03.009","article-title":"Patients receiving knee arthroplasty with pre-existing long-term aspirin use suffer lower risk of perioperative complications but feel more postoperative pain","volume":"28","author":"Liang","year":"2023","journal-title":"J Orthop Sci"},{"key":"10.1016\/j.arth.2025.09.020_bib41","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1302\/0301-620X.104B9.BJJ-2022-0013.R1","article-title":"Temporal trends in comorbidity in adult elective hip and knee arthroplasty patients in England : a national population-based cohort study from the national joint registry","volume":"104-B","author":"Penfold","year":"2022","journal-title":"Bone Joint J"},{"key":"10.1016\/j.arth.2025.09.020_bib42","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0140-6736(15)60243-4","article-title":"Pharmacology of antithrombotic drugs: an assessment of oral antiplatelet and anticoagulant treatments","volume":"386","author":"Mega","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.arth.2025.09.020_bib43","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1177\/003335491513000614","article-title":"Preventive aspirin and other antiplatelet medication use among U.S. adults aged \u226540 years: data from the national health and nutrition examination survey, 2011\u20132012","volume":"130","author":"Gu","year":"2015","journal-title":"Public Health Rep"},{"key":"10.1016\/j.arth.2025.09.020_bib44","series-title":"Physiology, Thromboxane A2. StatPearls","author":"Rucker","year":"2024"},{"key":"10.1016\/j.arth.2025.09.020_bib45","doi-asserted-by":"crossref","first-page":"327","DOI":"10.4330\/wjc.v8.i5.327","article-title":"P2Y12-ADP receptor antagonists: days of future and past","volume":"8","author":"Laine","year":"2016","journal-title":"World J Cardiol"},{"key":"10.1016\/j.arth.2025.09.020_bib46","article-title":"Global antiplatelet sales trend: a focus on P2Y12 inhibitors from 2008 to 2018","volume":"4","author":"Ye","year":"2021","journal-title":"Am Heart J Plus"},{"key":"10.1016\/j.arth.2025.09.020_bib47","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1161\/01.CIR.0000063575.17904.4E","article-title":"American heart association\/American college of cardiology foundation guide to warfarin therapy","volume":"107","author":"Hirsh","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.arth.2025.09.020_bib48","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.42964","article-title":"Trends in use of oral anticoagulants in older adults with newly diagnosed atrial fibrillation, 2010-2020","volume":"5","author":"Ko","year":"2022","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.arth.2025.09.020_bib49","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.026723","article-title":"Trends in oral anticoagulant use among 436 864 patients with atrial fibrillation in community practice, 2011 to 2020","volume":"11","author":"Navar","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.arth.2025.09.020_bib50","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.tcm.2019.03.004","article-title":"A review of reversal of oral anticoagulants, old and new, in major bleeding and the need for urgent surgery","volume":"30","author":"Milling","year":"2019","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.arth.2025.09.020_bib51","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/S0140-6736(20)32439-9","article-title":"Direct oral anticoagulants: evidence and unresolved issues","volume":"396","author":"Chan","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.arth.2025.09.020_bib52","doi-asserted-by":"crossref","DOI":"10.1056\/EVIDoa2300067","article-title":"Apixaban or warfarin in patients with an On-X mechanical aortic valve","volume":"2","author":"Wang","year":"2023","journal-title":"NEJM Evid"},{"key":"10.1016\/j.arth.2025.09.020_bib53","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1056\/NEJMoa1300615","article-title":"Dabigatran versus warfarin in patients with mechanical heart valves","volume":"369","author":"Eikelboom","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.arth.2025.09.020_bib54","first-page":"1","article-title":"New agents for DOAC reversal: a practical management review","volume":"29","author":"White","year":"2022","journal-title":"Br J Cardiol"},{"key":"10.1016\/j.arth.2025.09.020_bib55","series-title":"Low-Molecular-Weight Heparin (LMWH). StatPearls","author":"Solari","year":"2024"},{"key":"10.1016\/j.arth.2025.09.020_bib56","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5811\/westjem.2014.12.22933","article-title":"Anticoagulation drug therapy: a review","volume":"16","author":"Harter","year":"2015","journal-title":"West J Emerg Med"},{"key":"10.1016\/j.arth.2025.09.020_bib57","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s40138-013-0014-6","article-title":"Anticoagulants: a review of the pharmacology, dosing, and complications","volume":"1","author":"Alquwaizani","year":"2013","journal-title":"Curr Emerg Hosp Med Rep"},{"key":"10.1016\/j.arth.2025.09.020_bib58","doi-asserted-by":"crossref","first-page":"768","DOI":"10.5435\/00124635-201112000-00007","article-title":"Preventing venous thromboembolic disease in patients undergoing elective hip and knee arthroplasty","volume":"19","author":"Mont","year":"2011","journal-title":"J Am Acad Orthop Surg"},{"key":"10.1016\/j.arth.2025.09.020_bib59","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1056\/NEJMcp1411910","article-title":"Heparin-induced thrombocytopenia","volume":"373","author":"Greinacher","year":"2015","journal-title":"New Engl J Med"},{"key":"10.1016\/j.arth.2025.09.020_bib60","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.2106\/JBJS.L.00882","article-title":"Patients with atrial fibrillation undergoing total joint arthroplasty increase hospital burden","volume":"95","author":"Aggarwal","year":"2013","journal-title":"JBJS"},{"key":"10.1016\/j.arth.2025.09.020_bib61","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.arth.2013.12.029","article-title":"Ninety-day morbidity in patients undergoing primary TKA with discontinuation of warfarin and bridging with LMWH","volume":"29","author":"Gibon","year":"2014","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.09.020_bib62","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1001\/jamainternmed.2015.1843","article-title":"Bleeding, recurrent venous thromboembolism, and mortality risks during warfarin interruption for invasive procedures","volume":"175","author":"Clark","year":"2015","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.arth.2025.09.020_bib63","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.arth.2017.08.039","article-title":"Increased incidence of bleeding and wound complications with Factor-Xa inhibitors after total joint arthroplasty","volume":"33","author":"Garfinkel","year":"2018","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.09.020_bib64","doi-asserted-by":"crossref","first-page":"S412","DOI":"10.1016\/j.arth.2023.02.066","article-title":"Aspirin for venous thromboembolic prophylaxis following total hip and total knee arthroplasty: an analysis of safety and efficacy accounting for surgeon selection bias","volume":"38","author":"Heckmann","year":"2023","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.09.020_bib65","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/ajg.2013.108","article-title":"Risk of gastrointestinal bleeding in patients undergoing total hip or knee replacement compared with matched controls: a nationwide cohort study","volume":"108","author":"Lalmohamed","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.arth.2025.09.020_bib66","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/j.arth.2021.02.015","article-title":"Risk of gastrointestinal bleeding with extended use of nonsteroidal anti-inflammatory drug analgesia after joint arthroplasty","volume":"36","author":"Fleischman","year":"2021","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.09.020_bib67","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.2106\/JBJS.23.01158","article-title":"Low-dose aspirin is the safest prophylaxis for prevention of venous thromboembolism after total knee arthroplasty across all patient risk profiles","volume":"106","author":"Lavu","year":"2024","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2025.09.020_bib68","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.artd.2021.04.005","article-title":"The association between clopidogrel and gastrointestinal bleeding after primary total joint arthroplasty","volume":"9","author":"Kugelman","year":"2021","journal-title":"Arthroplast Today"},{"key":"10.1016\/j.arth.2025.09.020_bib69","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1161\/CIRCULATIONAHA.118.036459","article-title":"Cardiovascular effects of treatment with the ketone body 3-Hydroxybutyrate in chronic heart failure patients","volume":"139","author":"Nielsen","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.arth.2025.09.020_bib70","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.arth.2012.07.033","article-title":"Hematoma following primary total hip arthroplasty: a grave complication","volume":"28","author":"Mortazavi","year":"2013","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.09.020_bib71","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.arth.2012.11.003","article-title":"Complications of perioperative warfarin therapy in total knee arthroplasty","volume":"29","author":"Simpson","year":"2014","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.09.020_bib72","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/AAP.0000000000000763","article-title":"Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American society of regional anesthesia and pain medicine evidence-based guidelines (fourth edition)","volume":"43","author":"Horlocker","year":"2018","journal-title":"Reg Anesth Pain Med"},{"key":"10.1016\/j.arth.2025.09.020_bib73","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.bjae.2018.05.007","article-title":"Perioperative management of oral anticoagulation","volume":"18","author":"McIlmoyle","year":"2018","journal-title":"BJA Education"},{"key":"10.1016\/j.arth.2025.09.020_bib74","doi-asserted-by":"crossref","first-page":"S391","DOI":"10.1016\/j.arth.2024.01.020","article-title":"Chronic anticoagulation is associated with increased risk for postoperative complications following aseptic revision total hip arthroplasty","volume":"39","author":"Heo","year":"2024","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.09.020_bib75","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.arth.2023.10.056","article-title":"Patients who have a prior history of pulmonary embolism require increased postoperative care following total joint arthroplasty","volume":"39","author":"Reynolds","year":"2024","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.09.020_bib76","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.arth.2024.09.038","article-title":"Chronic anticoagulation in patients who have atrial fibrillation undergoing outpatient total knee arthroplasty: a retrospective matched cohort study","volume":"40","author":"Singh","year":"2024","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.09.020_bib77","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1016\/j.jacc.2022.04.021","article-title":"Preoperative atrial fibrillation and cardiovascular outcomes after noncardiac surgery","volume":"79","author":"Prasada","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.arth.2025.09.020_bib78","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0735-1097(01)01742-9","article-title":"Coronary in-stent restenosis: current status and future strategies","volume":"39","author":"Lowe","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.arth.2025.09.020_bib79","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jclinane.2016.07.028","article-title":"Perioperative antiplatelet therapy and cardiovascular outcomes in patients undergoing joint and spine surgery","volume":"35","author":"Smilowitz","year":"2016","journal-title":"J Clin Anesth"},{"key":"10.1016\/j.arth.2025.09.020_bib80","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.jacc.2016.11.024","article-title":"2017 ACC expert consensus decision pathway for periprocedural management of anticoagulation in patients with nonvalvular atrial fibrillation: a report of the American college of cardiology clinical expert consensus document task force","volume":"69","author":"Doherty","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.arth.2025.09.020_bib81","doi-asserted-by":"crossref","first-page":"e351","DOI":"10.1161\/CIR.0000000000001285","article-title":"2024 AHA\/ACC\/ACS\/ASNC\/HRS\/SCA\/SCCT\/SCMR\/SVM guideline for perioperative cardiovascular management for noncardiac surgery: a report of the American college of cardiology\/American heart association joint committee on clinical practice guidelines","volume":"150","author":"Thompson","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.arth.2025.09.020_bib82","doi-asserted-by":"crossref","first-page":"e207","DOI":"10.1016\/j.chest.2022.07.025","article-title":"Perioperative management of antithrombotic therapy: an American college of chest physicians clinical practice guideline","volume":"162","author":"Douketis","year":"2022","journal-title":"CHEST"},{"key":"10.1016\/j.arth.2025.09.020_bib83","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.jamcollsurg.2018.08.183","article-title":"American college of surgeons\u2019 guidelines for the perioperative management of antithrombotic medication","volume":"227","author":"Hornor","year":"2018","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.arth.2025.09.020_bib84","doi-asserted-by":"crossref","first-page":"878","DOI":"10.5435\/JAAOS-D-17-00827","article-title":"Preoperative management of antithrombotics in arthroplasty","volume":"27","author":"Barlow","year":"2019","journal-title":"J Am Acad Orthop Surg"},{"key":"10.1016\/j.arth.2025.09.020_bib85","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/clc.22435","article-title":"The HAS-BLED score for predicting major bleeding risk in anticoagulated patients with atrial fibrillation: a systematic review and meta-analysis","volume":"38","author":"Zhu","year":"2015","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.arth.2025.09.020_bib86","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/j.jvir.2020.06.014","volume":"31","author":"Kaufman","year":"2020","journal-title":"J Vasc Interv Radiol"},{"key":"10.1016\/j.arth.2025.09.020_bib87","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1055\/s-0036-1581088","article-title":"Inferior vena cava filters: guidelines, best practice, and expanding indications","volume":"33","author":"DeYoung","year":"2016","journal-title":"Semin Intervent Radiol"},{"key":"10.1016\/j.arth.2025.09.020_bib88","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1016\/j.chest.2021.07.056","article-title":"Executive summary: antithrombotic therapy for VTE disease: Second update of the CHEST guideline and expert panel report","volume":"160","author":"Stevens","year":"2021","journal-title":"Chest"},{"key":"10.1016\/j.arth.2025.09.020_bib89","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.surge.2019.10.003","article-title":"IVC filter removal after extended implantation periods","volume":"18","author":"Jaberi","year":"2020","journal-title":"Surgeon"},{"key":"10.1016\/j.arth.2025.09.020_bib90","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1053\/j.semvascsurg.2013.04.005","article-title":"Complications of inferior vena cava filters","volume":"26","author":"Sella","year":"2013","journal-title":"Semin Vasc Surg"},{"key":"10.1016\/j.arth.2025.09.020_bib91","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1007\/s00590-023-03531-z","article-title":"The use of pre-operative inferior vena cava filters for thromboprophylaxis in ultra-high-risk patients undergoing total hip and knee arthroplasty: a systematic review and narrative analysis","volume":"33","author":"Sochart","year":"2023","journal-title":"Eur J Orthop Surg Traumatol"},{"key":"10.1016\/j.arth.2025.09.020_bib92","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1213\/ANE.0000000000005064","article-title":"A comprehensive update on aspirin management during noncardiac surgery","volume":"131","author":"Gerstein","year":"2020","journal-title":"Anesth Analg"},{"key":"10.1016\/j.arth.2025.09.020_bib93","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s40140-021-00511-z","article-title":"Perioperative guidelines on antiplatelet and anticoagulant agents: 2022 update","volume":"12","author":"Moster","year":"2022","journal-title":"Curr Anesthesiol Rep"},{"key":"10.1016\/j.arth.2025.09.020_bib94","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1007\/s00402-020-03629-7","article-title":"Is continuation of anti-platelet treatment safe for elective total hip arthroplasty patients?","volume":"140","author":"Ashkenazi","year":"2020","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/j.arth.2025.09.020_bib95","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00590-016-1830-7","article-title":"Comparison of preoperative continuation and discontinuation of aspirin in patients undergoing total hip or knee arthroplasty","volume":"26","author":"Meier","year":"2016","journal-title":"Eur J Orthop Surg Traumatol"},{"key":"10.1016\/j.arth.2025.09.020_bib96","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1007\/s00167-015-3824-0","article-title":"Aspirin mono-therapy continuation does not result in more bleeding after knee arthroplasty","volume":"25","author":"Schwab","year":"2017","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.arth.2025.09.020_bib97","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.jacc.2015.08.002","article-title":"Bridging anticoagulation: primum non nocere","volume":"66","author":"Rechenmacher","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.arth.2025.09.020_bib98","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s00402-014-2034-4","article-title":"High complication rate after total knee and hip replacement due to perioperative bridging of anticoagulant therapy based on the 2012 ACCP guideline","volume":"134","author":"Leijtens","year":"2014","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/j.arth.2025.09.020_bib99","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s13018-015-0285-6","article-title":"Bridging therapy for oral anticoagulation increases the risk for bleeding-related complications in total joint arthroplasty","volume":"10","author":"Haighton","year":"2015","journal-title":"J Orthop Surg Res"},{"key":"10.1016\/j.arth.2025.09.020_bib100","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1016\/j.arth.2022.04.005","article-title":"Is it safe to continue clopidogrel in elective hip and knee arthroplasty?","volume":"37","author":"Maxfield","year":"2022","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.09.020_bib101","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.arth.2013.06.008","article-title":"Continuing clopidogrel during elective total hip and knee arthroplasty: assessment of bleeding risk and adverse outcomes","volume":"29","author":"Jacob","year":"2014","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.09.020_bib102","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.arth.2023.11.012","article-title":"Safety of early surgery in hip fracture patients taking clopidogrel and\/or aspirin: a systematic review and meta-analysis","volume":"39","author":"Lu","year":"2024","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2025.09.020_bib103","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3928\/01477447-20240304-04","article-title":"Evaluation of the safety of uninterrupted warfarin anticoagulation with tranexamic acid in total joint arthroplasty","volume":"47","author":"Johnston","year":"2024","journal-title":"Orthopedics"},{"key":"10.1016\/j.arth.2025.09.020_bib104","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1001\/jamainternmed.2019.2431","article-title":"Perioperative management of patients with atrial fibrillation receiving a direct oral anticoagulant","volume":"179","author":"Douketis","year":"2019","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.arth.2025.09.020_bib105","first-page":"490","article-title":"The perioperative management of antiplatelet and anticoagulant drugs in hip fractures: do the surgery as early as possible","volume":"10","author":"Ghasemi","year":"2022","journal-title":"Arch Bone Jt Surg"},{"key":"10.1016\/j.arth.2025.09.020_bib106","article-title":"Surgical site infections and other postoperative complications following prophylactic anticoagulation in total joint arthroplasty","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.arth.2025.09.020_bib107","article-title":"Randomised comparative effectiveness trial of pulmonary embolism prevention after hiP and kneE replacement (PEPPER): the PEPPER trial protocol","volume":"12","author":"Vincent","year":"2022","journal-title":"BMJ Open"},{"key":"10.1016\/j.arth.2025.09.020_bib108","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1002\/acr.24893","article-title":"2022 American college of rheumatology\/American association of hip and knee surgeons guideline for the perioperative management of antirheumatic medication in patients with rheumatic diseases undergoing elective total hip or total knee arthroplasty","volume":"74","author":"Goodman","year":"2022","journal-title":"Arthritis Care Res (Hoboken)"}],"container-title":["The Journal of Arthroplasty"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540325011842?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540325011842?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T11:48:01Z","timestamp":1775908081000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883540325011842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":108,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S0883540325011842"],"URL":"https:\/\/doi.org\/10.1016\/j.arth.2025.09.020","relation":{},"ISSN":["0883-5403"],"issn-type":[{"value":"0883-5403","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Management of Chronic Antithrombotic Medication in Total Joint Arthroplasty: A Primer for the Orthopaedic Surgeon","name":"articletitle","label":"Article Title"},{"value":"The Journal of Arthroplasty","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arth.2025.09.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}