{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T03:15:45Z","timestamp":1783134945507,"version":"3.54.6"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["R41DA059303"],"award-info":[{"award-number":["R41DA059303"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["arthroplastyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Arthroplasty"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.arth.2026.04.083","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:05:35Z","timestamp":1777939535000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nanotechnology-Based Device Reduces Pain and Immediate Opioid Requirements and Facilitates Earlier Discharge From the Hospital Following Total Knee Arthroplasty: A Randomized Placebo-Controlled Trial"],"prefix":"10.1016","author":[{"given":"Brian A.","family":"Klatt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"O\u2019Malley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akbota","family":"Ayazbekova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsing-Hua Sylvia","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senthilkumar","family":"Sadhasivam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5715-5482","authenticated-orcid":false,"given":"Jacques E.","family":"Chelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arth.2026.04.083_bib1","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.2106\/JBJS.17.01617","article-title":"Projected volume of primary total joint arthroplasty in the U.S., 2014 to 2030","volume":"100","author":"Sloan","year":"2018","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2026.04.083_bib2","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1515\/sjpain-2021-0062","article-title":"Associations of health-related quality of life with sociodemographic characteristics, health, pain, and lifestyle factors, and motivation for changing lifestyle in adults living with chronic pain: a cross-sectional exploratory study","volume":"22","author":"Nielsen","year":"2022","journal-title":"Scand J Pain"},{"key":"10.1016\/j.arth.2026.04.083_bib3","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1001\/jamainternmed.2016.3298","article-title":"Incidence of and risk factors for chronic opioid use among opioid-na\u00efve patients in the postoperative period","volume":"176","author":"Sun","year":"2016","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.arth.2026.04.083_bib4","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1016\/S0140-6736(06)68700-X","article-title":"Persistent postsurgical pain: risk factors and prevention","volume":"367","author":"Kehlet","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.arth.2026.04.083_bib5","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.2147\/JPR.S144066","article-title":"Poorly controlled postoperative pain: prevalence, consequences, and prevention","volume":"10","author":"Gan","year":"2017","journal-title":"J Pain Res"},{"key":"10.1016\/j.arth.2026.04.083_bib6","doi-asserted-by":"crossref","first-page":"7394","DOI":"10.3390\/jcm12237394","article-title":"Role of the NeuroCupleTM device for the postoperative pain management of patients undergoing unilateral primary total knee and hip arthroplasty: a pilot prospective, randomized, open-label study","volume":"12","author":"Chelly","year":"2023","journal-title":"J Clin Med"},{"key":"10.1016\/j.arth.2026.04.083_bib7","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.1016\/j.arth.2017.10.060","article-title":"Trends in opioid utilization before and after total knee arthroplasty","volume":"33","author":"Politzer","year":"2018","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2026.04.083_bib8","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/ALN.0000000000004510","article-title":"Prolonged opioid use and pain outcome and associated factors after surgery under general anesthesia: a prospective cohort association multicenter study","volume":"138","author":"Kuck","year":"2023","journal-title":"Anesthesiology"},{"key":"10.1016\/j.arth.2026.04.083_bib9","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jacbts.2024.01.008","article-title":"Is it time to abandon the use of P-Values in early phase translational trials: why (effect) size matters","volume":"9","author":"Mann","year":"2024","journal-title":"JACC Basic Transl Sci"},{"key":"10.1016\/j.arth.2026.04.083_bib10","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/ALN.0b013e31823c1030","article-title":"Practice guidelines for acute pain management in the perioperative setting: an updated report by the American Society of Anesthesiologists Task Force on acute pain management","volume":"116","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1016\/j.arth.2026.04.083_bib11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jpain.2015.12.008","volume":"17","author":"Chou","year":"2016","journal-title":"J Pain"},{"key":"10.1016\/j.arth.2026.04.083_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.rr7103a1","article-title":"CDC clinical practice guideline for prescribing opioids for pain - United States, 2022","volume":"71","author":"Dowell","year":"2022","journal-title":"MMWR Recomm Rep"},{"key":"10.1016\/j.arth.2026.04.083_bib13","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-035126","article-title":"State-level variation in opioid prescribing after knee arthroscopy among the opioid-naive in the USA: 2015-2019","volume":"10","author":"Ukert","year":"2020","journal-title":"BMJ Open"},{"key":"10.1016\/j.arth.2026.04.083_bib14","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ocl.2017.05.001","article-title":"Perioperative pain management in hip and knee arthroplasty","volume":"48","author":"Gaffney","year":"2017","journal-title":"Orthop Clin North Am"},{"key":"10.1016\/j.arth.2026.04.083_bib15","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-067542","article-title":"Opioid prescriptions after knee replacement: a retrospective study of pathways and prognostic factors in the Swiss healthcare setting","volume":"13","author":"Wirth","year":"2023","journal-title":"BMJ Open"},{"key":"10.1016\/j.arth.2026.04.083_bib16","article-title":"Postoperative patient pain severity and its association with anxiety, depression, and sleep quality","volume":"16","author":"Husni","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.arth.2026.04.083_bib17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12893-016-0120-y","article-title":"Depression and postoperative complications: an overview","volume":"16","author":"Ghoneim","year":"2016","journal-title":"BMC Surg"},{"key":"10.1016\/j.arth.2026.04.083_bib18","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/anae.16188","article-title":"The impact of pre-operative depression on pain outcomes after major surgery: a systematic review and meta-analysis","volume":"79","author":"Lee","year":"2024","journal-title":"Anaesthesia"},{"key":"10.1016\/j.arth.2026.04.083_bib19","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1186\/s13018-022-03288-x","article-title":"Sleep disturbance, dyspnea, and anxiety following total joint arthroplasty: an observational study","volume":"17","author":"George","year":"2022","journal-title":"J Orthop Surg Res"},{"key":"10.1016\/j.arth.2026.04.083_bib20","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1302\/0301-620X.104B4.BJJ-2021-1089.R1","article-title":"PROMIS depression and anxiety in shoulder surgery patients","volume":"104-b","author":"Baker","year":"2022","journal-title":"Bone Joint J"},{"key":"10.1016\/j.arth.2026.04.083_bib21","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1177\/0951484817696212","article-title":"Patient length of stay and mortality prediction: a survey","volume":"30","author":"Awad","year":"2017","journal-title":"Health Serv Manage Res"},{"key":"10.1016\/j.arth.2026.04.083_bib22","article-title":"A systematic review of length of stay linked to hospital-acquired falls, pressure ulcers, central line-associated bloodstream infections, and surgical site infections","volume":"9","author":"Hasan","year":"2025","journal-title":"Mayo Clin Proc Innov Qual Outcomes"},{"key":"10.1016\/j.arth.2026.04.083_bib23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.2106\/JBJS.16.00019","article-title":"Effects of the length of stay on the cost of total knee and total hip arthroplasty from 2002 to 2013","volume":"99","author":"Molloy","year":"2017","journal-title":"J Bone Joint Surg Am"}],"container-title":["The Journal of Arthroplasty"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540326004183?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540326004183?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T02:21:30Z","timestamp":1783131690000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883540326004183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":23,"alternative-id":["S0883540326004183"],"URL":"https:\/\/doi.org\/10.1016\/j.arth.2026.04.083","relation":{},"ISSN":["0883-5403"],"issn-type":[{"value":"0883-5403","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanotechnology-Based Device Reduces Pain and Immediate Opioid Requirements and Facilitates Earlier Discharge From the Hospital Following Total Knee Arthroplasty: A Randomized Placebo-Controlled Trial","name":"articletitle","label":"Article Title"},{"value":"The Journal of Arthroplasty","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arth.2026.04.083","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}