{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:55:01Z","timestamp":1790805301261,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004880","name":"Xinjiang Medical University","doi-asserted-by":"publisher","award":["2023YFY-QKMS-07"],"award-info":[{"award-number":["2023YFY-QKMS-07"]}],"id":[{"id":"10.13039\/501100004880","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["arthroplastyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Arthroplasty"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.arth.2026.05.065","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:36:46Z","timestamp":1782171406000},"page":"S299-S307","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"S1","title":["Efficacy of Intraosseous Tranexamic Acid in Primary Total Hip Arthroplasty: A Prospective Randomized Controlled Trial"],"prefix":"10.1016","volume":"41","author":[{"given":"Yongjie","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6136-2206","authenticated-orcid":false,"given":"Baochao","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arth.2026.05.065_bib1","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/S0140-6736(12)60607-2","article-title":"Hip arthroplasty","volume":"380","author":"Pivec","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.arth.2026.05.065_bib2","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1016\/j.arth.2014.07.019","article-title":"Comparison of topical and intravenous tranexamic acid on blood loss and transfusion rates in total hip arthroplasty","volume":"29","author":"Wei","year":"2014","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2026.05.065_bib3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.arth.2024.06.053","article-title":"Blood transfusion in the age of tranexamic acid: who needs a type and screen before total hip arthroplasty?","volume":"40","author":"Haider","year":"2025","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2026.05.065_bib4","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.2106\/JBJS.24.01511","article-title":"Topical versus systemic tranexamic acid to reduce blood loss after total knee and total hip arthroplasty: a systematic review and meta-analysis","volume":"107","author":"Boucher","year":"2025","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2026.05.065_bib5","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1016\/j.arth.2018.06.023","article-title":"The efficacy of tranexamic acid in total hip arthroplasty: a network meta-analysis","volume":"33","author":"Fillingham","year":"2018","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2026.05.065_bib6","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/EJA.0000000000001950","article-title":"Oral as compared to intravenous tranexamic acid to limit peri-operative blood loss associated with primary total hip arthroplasty: a randomised noninferiority trial","volume":"41","author":"Piette","year":"2024","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.arth.2026.05.065_bib7","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.arth.2015.11.003","article-title":"Topical vs intravenous tranexamic acid in primary total hip arthroplasty: a double-blind, randomized controlled trial","volume":"31","author":"North","year":"2016","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2026.05.065_bib8","doi-asserted-by":"crossref","first-page":"983","DOI":"10.2106\/JBJS.15.00638","article-title":"Tranexamic acid administration in primary total hip arthroplasty: a randomized controlled trial of intravenous combined with topical versus single-dose intravenous administration","volume":"98","author":"Yi","year":"2016","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2026.05.065_bib9","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.2106\/JBJS.15.01010","article-title":"The Michigan experience with safety and effectiveness of tranexamic acid use in hip and knee arthroplasty","volume":"98","author":"Hallstrom","year":"2016","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2026.05.065_bib10","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.arth.2022.01.057","article-title":"Higher tissue concentrations of vancomycin achieved with low-dose intraosseous injection versus intravenous despite limited tourniquet duration in primary total knee arthroplasty: a randomized trial","volume":"37","author":"Spangehl","year":"2022","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2026.05.065_bib11","doi-asserted-by":"crossref","first-page":"S224","DOI":"10.1016\/j.arth.2024.02.083","article-title":"Intraosseous versus intravenous vancomycin in tourniquetless primary total knee arthroplasty: a randomized trial","volume":"39","author":"Wininger","year":"2024","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2026.05.065_bib12","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.jss.2024.08.003","article-title":"Intravenous versus intraosseous use of tranexamic acid in patients with traumatic brain injury","volume":"302","author":"Newman","year":"2024","journal-title":"J Surg Res"},{"key":"10.1016\/j.arth.2026.05.065_bib13","doi-asserted-by":"crossref","first-page":"746","DOI":"10.2106\/JBJS.9408.ebo746","article-title":"American academy of orthopedic surgeons clinical practice guideline on: preventing venous thromboembolic disease in patients undergoing elective hip and knee arthroplasty","volume":"94","author":"Jacobs","year":"2012","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2026.05.065_bib14","doi-asserted-by":"crossref","first-page":"704","DOI":"10.12659\/MSM.900059","article-title":"Comparison of enoxaparin and rivaroxaban in balance of anti-fibrinolysis and anticoagulation following primary total knee replacement: a pilot study","volume":"23","author":"Xie","year":"2017","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.arth.2026.05.065_bib15","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1007\/s00264-023-05893-9","article-title":"Efficacy and safety of postoperative single-dose anticoagulant treatment in preventing venous thromboembolism after revision hip arthroplasty: a retrospective cohort study","volume":"47","author":"Chu","year":"2023","journal-title":"Int Orthop"},{"key":"10.1016\/j.arth.2026.05.065_bib16","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1001\/jama.2016.9185","article-title":"Clinical practice guidelines from the AABB: red blood cell transfusion thresholds and storage","volume":"316","author":"Carson","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.arth.2026.05.065_bib17","first-page":"224","article-title":"Prediction of blood volume in normal human adults","volume":"51","author":"Nadler","year":"1962","journal-title":"Surgery"},{"key":"10.1016\/j.arth.2026.05.065_bib18","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/00000542-198303000-00016","article-title":"Estimating allowable blood loss: corrected for dilution","volume":"58","author":"Gross","year":"1983","journal-title":"Anesthesiology"},{"key":"10.1016\/j.arth.2026.05.065_bib19","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.arth.2010.11.013","article-title":"Hidden blood loss after total hip arthroplasty","volume":"26","author":"Liu","year":"2011","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2026.05.065_bib20","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/pst.1716","article-title":"Practical guide to sample size calculations: non-inferiority and equivalence trials","volume":"15","author":"Flight","year":"2016","journal-title":"Pharm Stat"},{"key":"10.1016\/j.arth.2026.05.065_bib21","doi-asserted-by":"crossref","DOI":"10.1177\/10225536231151345","article-title":"Paracetamol versus paracetamol\/tramadol in postoperative intertrochanteric fracture: a noninferiority, randomized, controlled, double-blind study","volume":"31","author":"Sirithiantong","year":"2023","journal-title":"J Orthop Surg (Hong Kong)"},{"key":"10.1016\/j.arth.2026.05.065_bib22","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.21037\/apm-19-372","article-title":"Efficacy and safety of tranexamic acid in unilateral major revision total hip arthroplasty","volume":"9","author":"Mei","year":"2020","journal-title":"Ann Palliat Med"},{"key":"10.1016\/j.arth.2026.05.065_bib23","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s11999-012-2469-2","article-title":"Higher cefazolin concentrations with intraosseous regional prophylaxis in TKA","volume":"471","author":"Young","year":"2013","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.arth.2026.05.065_bib24","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1186\/s12891-025-09193-8","article-title":"A comparison of efficacy and safety of oral versus intravenous applications of tranexamic acid in total hip and knee arthroplasty: an updated systematic review meta-analysis of randomized controlled trials","volume":"26","author":"Feng","year":"2025","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.arth.2026.05.065_bib25","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s11999-012-2488-z","article-title":"Low risk of thromboembolic complications with tranexamic acid after primary total hip and knee arthroplasty","volume":"471","author":"Gillette","year":"2013","journal-title":"Clin Orthop Relat Res"},{"issue":"9S","key":"10.1016\/j.arth.2026.05.065_bib26","doi-asserted-by":"crossref","first-page":"S246","DOI":"10.1016\/j.arth.2017.02.008","article-title":"Tranexamic acid was safe in arthroplasty patients with a history of venous thromboembolism: a matched outcome study","volume":"32","author":"Sabbag","year":"2017","journal-title":"J Arthroplasty"}],"container-title":["The Journal of Arthroplasty"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540326005875?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540326005875?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:57:35Z","timestamp":1790801855000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883540326005875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0883540326005875"],"URL":"https:\/\/doi.org\/10.1016\/j.arth.2026.05.065","relation":{},"ISSN":["0883-5403"],"issn-type":[{"value":"0883-5403","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of Intraosseous Tranexamic Acid in Primary Total Hip Arthroplasty: A Prospective Randomized Controlled Trial","name":"articletitle","label":"Article Title"},{"value":"The Journal of Arthroplasty","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arth.2026.05.065","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}