{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:46:02Z","timestamp":1791953162133,"version":"4.3.4"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["arthroplastyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Arthroplasty"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.arth.2026.08.068","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:47:42Z","timestamp":1789516062000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biological Age Acceleration Predicts Functional Decline and Surgical Risk in Knee Arthroplasty"],"prefix":"10.1016","author":[{"given":"Naoki","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2324-3780","authenticated-orcid":false,"given":"Mitsuru","family":"Yagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Naito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Ohtani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Retsu","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arth.2026.08.068_bib1","doi-asserted-by":"crossref","first-page":"963","DOI":"10.2106\/00004623-200405000-00012","article-title":"Health-related quality of life in total hip and total knee arthroplasty. A qualitative and systematic review of the literature","volume":"86","author":"Ethgen","year":"2004","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.arth.2026.08.068_bib2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0883-5403(05)80123-8","article-title":"Health and quality of life before and after hip or knee arthroplasty","volume":"10","author":"Rissanen","year":"1995","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2026.08.068_bib3","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s42836-023-00175-6","article-title":"Epidemiology of primary and revision total knee arthroplasty: analysis of demographics, comorbidities and outcomes from the national inpatient sample","volume":"5","author":"Nham","year":"2023","journal-title":"Arthroplasty"},{"key":"10.1016\/j.arth.2026.08.068_bib4","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.jos.2020.07.022","article-title":"Trends in arthroplasty in Japan by a complete survey, 2014-2017","volume":"26","author":"Katano","year":"2021","journal-title":"J Orthop Sci"},{"key":"10.1016\/j.arth.2026.08.068_bib5","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1186\/s12893-025-03050-0","article-title":"Risk of complications associated with prolonged post-operative hospitalization and postoperative outcomes in elderly patients with high BMI undergoing elective total knee arthroplasty","volume":"25","author":"Wang","year":"2025","journal-title":"BMC Surg"},{"key":"10.1016\/j.arth.2026.08.068_bib6","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3109\/17453674.2015.1040304","article-title":"Longer hospital stay, more complications, and increased mortality but substantially improved function after knee replacement in older patients","volume":"86","author":"Maempel","year":"2015","journal-title":"Acta Orthop"},{"key":"10.1016\/j.arth.2026.08.068_bib7","doi-asserted-by":"crossref","first-page":"S169","DOI":"10.1016\/j.arth.2023.04.005","article-title":"Age-Related differences in pain, function, and quality of life following primary total knee arthroplasty: results from a FORCE-TJR (Function and outcomes research for comparative effectiveness in total joint replacement) cohort","volume":"38","author":"Ayers","year":"2023","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2026.08.068_bib8","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.arth.2026.08.068_bib9","doi-asserted-by":"crossref","first-page":"E4104","DOI":"10.1073\/pnas.1506264112","article-title":"Quantification of biological aging in young adults","volume":"112","author":"Belsky","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.arth.2026.08.068_bib10","doi-asserted-by":"crossref","first-page":"573","DOI":"10.18632\/aging.101414","article-title":"An epigenetic biomarker of aging for lifespan and healthspan","volume":"10","author":"Levine","year":"2018","journal-title":"Aging"},{"key":"10.1016\/j.arth.2026.08.068_bib11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.socscimed.2014.07.022","article-title":"Evidence of accelerated aging among African Americans and its implications for mortality","volume":"118","author":"Levine","year":"2014","journal-title":"Soc Sci Med"},{"key":"10.1016\/j.arth.2026.08.068_bib12","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/ije\/dyw041","article-title":"The epigenetic clock and telomere length are independently associated with chronological age and mortality","volume":"45","author":"Marioni","year":"2016","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.arth.2026.08.068_bib13","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/BRS.0000000000005370","article-title":"Comparative analysis of biological aging and inflammatory profiles in adult spinal deformity patients between Japan and the United States: a correlative Study","volume":"51","author":"Yagi","year":"2026","journal-title":"Spine"},{"key":"10.1016\/j.arth.2026.08.068_bib14","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1016\/j.spinee.2025.04.001","article-title":"Accelerated biological aging in patients with degenerative spine diseases: the impact of modifiable lifestyle factors on phenotypic age","volume":"25","author":"Yagi","year":"2025","journal-title":"Spine J"},{"key":"10.1016\/j.arth.2026.08.068_bib15","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s43856-024-00706-5","article-title":"A prospective study of associations between accelerated biological aging and twenty musculoskeletal disorders","volume":"4","author":"Wei","year":"2024","journal-title":"Commun Med"},{"key":"10.1016\/j.arth.2026.08.068_bib16","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/jcsm.13110","article-title":"Grip strength is inversely associated with DNA methylation age acceleration","volume":"14","author":"Peterson","year":"2023","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.arth.2026.08.068_bib17","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: revised European consensus on definition and diagnosis","volume":"48","author":"Cruz-Jentoft","year":"2019","journal-title":"Age Ageing"},{"key":"10.1016\/j.arth.2026.08.068_bib18","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1471-2474-7-53","article-title":"Towards standardized measurement of adverse events in spine surgery: conceptual model and pilot evaluation","volume":"7","author":"Mirza","year":"2006","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.arth.2026.08.068_bib19","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jss.2013.01.021","article-title":"Accumulating deficits model of frailty and postoperative mortality and morbidity: its application to a national database","volume":"183","author":"Velanovich","year":"2013","journal-title":"J Surg Res"},{"key":"10.1016\/j.arth.2026.08.068_bib20","series-title":"Applied predictive analytics: principles and techniques for the professional data analyst","author":"Abbott","year":"2014"},{"key":"10.1016\/j.arth.2026.08.068_bib21","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1007\/s11357-023-00880-9","article-title":"Systemic inflammation and biological aging in the Health and Retirement Study","volume":"45","author":"Meier","year":"2023","journal-title":"Geroscience"},{"key":"10.1016\/j.arth.2026.08.068_bib22","doi-asserted-by":"crossref","first-page":"1451737","DOI":"10.3389\/fpubh.2024.1451737","article-title":"The association between accelerated biological aging and the risk of osteoarthritis: a cross-sectional study","volume":"12","author":"He","year":"2024","journal-title":"Front Public Health"},{"key":"10.1016\/j.arth.2026.08.068_bib23","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.joca.2023.11.024","article-title":"Assessing the association of epigenetic age acceleration with osteoarthritis in the Multicenter Osteoarthritis Study (MOST)","volume":"32","author":"Yau","year":"2024","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.arth.2026.08.068_bib24","doi-asserted-by":"crossref","first-page":"389","DOI":"10.4055\/cios24479","article-title":"The effect of enhanced recovery after surgery protocol in orthopedic hip surgery: a systematic review and meta-analysis","volume":"17","author":"Lee","year":"2025","journal-title":"Clin Orthop Surg"},{"key":"10.1016\/j.arth.2026.08.068_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0166844","article-title":"Incidence of deep vein thrombosis and venous thromboembolism following TKA in Rheumatoid arthritis versus osteoarthritis: a meta-analysis","volume":"11","author":"Lee","year":"2016","journal-title":"PLoS One"}],"container-title":["The Journal of Arthroplasty"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540326009514?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540326009514?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:03:34Z","timestamp":1791950614000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883540326009514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":25,"alternative-id":["S0883540326009514"],"URL":"https:\/\/doi.org\/10.1016\/j.arth.2026.08.068","relation":{},"ISSN":["0883-5403"],"issn-type":[{"value":"0883-5403","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biological Age Acceleration Predicts Functional Decline and Surgical Risk in Knee Arthroplasty","name":"articletitle","label":"Article Title"},{"value":"The Journal of Arthroplasty","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arth.2026.08.068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}