{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:33:04Z","timestamp":1793226784763,"version":"4.5.0"},"reference-count":13,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["arthroplastyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Arthroplasty"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.arth.2026.09.043","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:08:54Z","timestamp":1791389334000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic Exposure and Renal Safety After Intrawound Vancomycin Powder in Primary Total Knee Arthroplasty: A Prospective Comparative Cohort Study"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1720-1709","authenticated-orcid":false,"given":"Olgun","family":"Bingol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taner","family":"Karlidag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan E.","family":"Ozsoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahsin","family":"Aydin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer H.","family":"Keskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bulent","family":"Ozkurt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arth.2026.09.043_bib1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0140-6736(14)61798-0","article-title":"Periprosthetic joint infection","volume":"387","author":"Kapadia","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.arth.2026.09.043_bib2","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.artd.2018.07.011","article-title":"Intrawound vancomycin in primary hip and knee arthroplasty: a safe and cost-effective means to decrease early periprosthetic joint infection","volume":"4","author":"Patel","year":"2018","journal-title":"Arthroplast Today"},{"key":"10.1016\/j.arth.2026.09.043_bib3","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1016\/j.arth.2020.02.030","article-title":"Projections and epidemiology of revision hip and knee arthroplasty in the United States to 2030","volume":"35","author":"Schwartz","year":"2020","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2026.09.043_bib4","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.arth.2015.10.015","article-title":"Serum and wound vancomycin levels after intrawound administration in primary total joint arthroplasty","volume":"32","author":"Johnson","year":"2017","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2026.09.043_bib5","doi-asserted-by":"crossref","first-page":"13053","DOI":"10.1038\/s41598-020-69958-0","article-title":"Intraarticular vancomycin powder is effective in preventing infections following total hip and knee arthroplasty","volume":"10","author":"Matziolis","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.arth.2026.09.043_bib6","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1016\/j.arth.2025.10.053","article-title":"Effect of vancomycin powder in reducing infection after primary and revision hip and knee arthroplasty and its complications: an umbrella review and meta-analysis","volume":"41","author":"Salimi","year":"2025","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2026.09.043_bib7","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.arth.2024.01.003","article-title":"Efficacy of intrawound vancomycin in prevention of periprosthetic joint infection after primary total knee arthroplasty: a prospective double-blinded randomized controlled trial","volume":"39","author":"Mulpur","year":"2024","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2026.09.043_bib8","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.1097\/JS9.0000000000002316","article-title":"Intrawound vancomycin powder for prevention of surgical site infections in primary joint arthroplasty: an umbrella review of systematic reviews and meta-analyses","volume":"111","author":"Zhu","year":"2025","journal-title":"Int J Surg"},{"key":"10.1016\/j.arth.2026.09.043_bib9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jor.2024.12.025","article-title":"Effectiveness of intra-articular vancomycin in preventing prosthetic joint infections in hip and knee arthroplasty: a systematic review and meta-analysis of randomized controlled trials","volume":"66","author":"da Cruz","year":"2025","journal-title":"J Orthop"},{"key":"10.1016\/j.arth.2026.09.043_bib10","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3390\/antibiotics14030214","article-title":"Effectiveness of local antibiotics for infection prevention in primary joint arthroplasty: a systematic review and meta-analysis","volume":"14","author":"Lin","year":"2025","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.arth.2026.09.043_bib11","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.arth.2018.02.078","article-title":"The 2018 definition of periprosthetic hip and knee infection: an evidence-based and validated criteria","volume":"33","author":"Parvizi","year":"2018","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.arth.2026.09.043_bib12","doi-asserted-by":"crossref","first-page":"c179","DOI":"10.1159\/000339789","article-title":"KDIGO clinical practice guidelines for acute kidney injury","volume":"120","author":"Khwaja","year":"2012","journal-title":"Nephron Clin Pract"},{"key":"10.1016\/j.arth.2026.09.043_bib13","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1097\/JS9.0000000000002373","article-title":"Commentary on: intrawound vancomycin powder for prevention of surgical site infections in primary joint arthroplasty: an umbrella review of systematic reviews and meta-analyses","volume":"111","author":"Yuan","year":"2025","journal-title":"Int J Surg"}],"container-title":["The Journal of Arthroplasty"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540326010570?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883540326010570?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:08:35Z","timestamp":1793225315000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883540326010570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":13,"alternative-id":["S0883540326010570"],"URL":"https:\/\/doi.org\/10.1016\/j.arth.2026.09.043","relation":{},"ISSN":["0883-5403"],"issn-type":[{"value":"0883-5403","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systemic Exposure and Renal Safety After Intrawound Vancomycin Powder in Primary Total Knee Arthroplasty: A Prospective Comparative Cohort Study","name":"articletitle","label":"Article Title"},{"value":"The Journal of Arthroplasty","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arth.2026.09.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}