{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T10:23:01Z","timestamp":1773570181546,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["arthroscopyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To clarify the effect of transforming growth factor (TGF)\u2010\u03b21 on intraosseous healing of the flexor tendon autograft in anterior cruciate ligament (ACL) replacement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Type of Study<\/jats:title>\n                    <jats:p>Randomized trial in animals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010one adult beagle dogs were divided into 3 groups of 7 animals each. The ACL was replaced with a flexor tendon autograft in the left knee. The distal end of each graft was placed in the tibial bone tunnel. In group I, no treatment was applied in the bone tunnel. In group II, 0.1 mL of fibrin sealant was applied in the tendon\u2010bone gap. In group III, 2 ng of TGF\u2010\u03b21 mixed with 0.1 mL fibrin sealant was applied in the gap. Each animal was euthanized 3 weeks after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In pullout testing, the ultimate load of the graft\u2010tibia complex of group III (188.2 \u00b1 51.4 N) was significantly greater than that of groups I (86.7 \u00b1 36.5 N) and II (99.0 \u00b1 18.7 N) (\n                      <jats:italic>P<\/jats:italic>\n                      = .005). There were no significant differences between groups I and II. Histologically, the perpendicular collagen fibers connecting the tendon to the bone were narrowly seen in groups I and II, whereas the fibers were richly generated in group III.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In ACL replacement using flexor tendon autograft, exogenous administration of TGF\u2010\u03b21 significantly increased the bonding strength of the graft to the tunnel wall at 3 weeks, although the long\u2010term effects are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>Intraosseous healing of the flexor tendon autograft in ACL reconstruction may be enhanced by a use of some growth factors involving TGF\u2010\u03b21 in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2005.05.011","type":"journal-article","created":{"date-parts":[[2005,9,19]],"date-time":"2005-09-19T07:02:10Z","timestamp":1127113330000},"page":"1034-1041","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":113,"title":["The Effect of Transforming Growth Factor\u2010\u03b21 on Intraosseous Healing of Flexor Tendon Autograft Replacement of Anterior Cruciate Ligament in Dogs"],"prefix":"10.1002","volume":"21","author":[{"given":"Shuji","family":"Yamazaki","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Hokkaido University School of Medicine Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine and Joint Reconstruction Surgery Hokkaido University School of Medicine Sapporo 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