{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:55:57Z","timestamp":1792634157833,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Patients with chronic anterior cruciate ligament (ACL) deficiency are at high risk of articular cartilage damage and the development of osteoarthritis (OA). It has been hypothesized that biochemical factors, such as cytokines, contribute to the process. The purpose of our study was to determine the concentrations of potentially chondrodestructive and chondroprotective cytokines in the chronic ACL\u2010deficient knee, and to determine if the cytokine profile or other factors correlated with the amount of chondral damage present in the knee.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Type of Study<\/jats:title>\n                    <jats:p>A consecutive series of patients who consented to the Institutional Review Board\u2013approved study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Synovial fluid lavages were obtained from 31 patients with ACL\u2010deficient knees. Four patients had lavages aspirated from their contralateral normal knee. These lavages were analyzed for interleukin (IL)\u20101\u03b1, IL\u20101\u03b2, IL\u20101ra, and tumor necrosis factor (TNF)\u2010\u03b1. At arthroscopy, the amount of chondral damage was graded based on the Outerbridge classification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Concentrations of chondrodestructive IL\u20101\u03b2 and TNF\u2010\u03b1 were significantly higher in patients with ACL ruptures than in the contralateral normal knees. The more severe the chondral damage, the higher the concentration of IL\u20101\u03b2 and TNF\u2010\u03b1. Chondroprotective cytokine concentrations decreased with increasing grades of chondral damage. We found a linear correlation between the severity of chondral damage and the time from injury (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      = .954).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A difference was seen in the cytokine profiles between the normal and injured knees. This difference varied based on the severity of chondral damage, which was associated with time from injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>Cytokine levels are associated with chondral damage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2005.08.034","type":"journal-article","created":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T07:30:25Z","timestamp":1133422225000},"page":"1342-1347","source":"Crossref","is-referenced-by-count":158,"title":["Inflammatory Cytokine Profiles Associated With Chondral Damage in the Anterior Cruciate Ligament\u2013Deficient Knee"],"prefix":"10.1002","volume":"21","author":[{"given":"Paul H.","family":"Marks","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery University of Toronto Orthopaedic and Arthritic Institute Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle L. Cameron","family":"Donaldson","sequence":"additional","affiliation":[{"name":"Livingston Orthopedic and Rehabilitation Institute Livingston Montana U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,1]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/036354658601400305"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198365020-00003"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199010000-00027"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-198401040-00004"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198062050-00002"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199274010-00020"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00186881"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/036354659402200511"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465000280040201"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar148"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-002-8402-1"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-002-8404-z"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-001-0064-8"},{"key":"e_1_2_2_15_1","first-page":"12","article-title":"Are cytokines involved in osteoarthritic pathophysiology?","volume":"20","author":"Pelletier J.P.","year":"1991","journal-title":"Arthritis Rheum"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/anr.1780320310"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112350"},{"key":"e_1_2_2_18_1","first-page":"80","article-title":"In vitro effects of IL\u20101 on synthesis of metalloproteases, TIMP, plasminogen activators and inhibitors in human articular cartilage","volume":"27","author":"Martel\u2010Pelletier J.","year":"1991","journal-title":"J Rheumatol Suppl"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.22.8749"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100060204"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.1.1.1"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780331113"},{"key":"e_1_2_2_23_1","article-title":"Modulation of the effects of interleukin\u20101 on glycosaminoglycan synthesis by the urine derived interleukin\u20101 inhibitor but not by interleukin\u20106","volume":"33","author":"Sechinger P.","year":"1990","journal-title":"Arthritis Rheum"},{"key":"e_1_2_2_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.139.5.1541"},{"key":"e_1_2_2_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/344633a0"},{"key":"e_1_2_2_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/343341a0"},{"key":"e_1_2_2_27_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.168.5.1767"},{"key":"e_1_2_2_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330412"},{"key":"e_1_2_2_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01972788"},{"key":"e_1_2_2_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/322547a0"},{"key":"e_1_2_2_31_1","first-page":"588","article-title":"Interleukin\u20106: a multifunctional cytokine regulating immune reactions and acute phase protein response","volume":"61","author":"Le J.M.","year":"1989","journal-title":"Lab Invest"},{"key":"e_1_2_2_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780360408"},{"key":"e_1_2_2_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830200533"},{"key":"e_1_2_2_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/036354659702500605"},{"key":"e_1_2_2_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01552652"},{"key":"e_1_2_2_36_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.43B4.752"},{"key":"e_1_2_2_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(89)90085-2"},{"key":"e_1_2_2_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-0348-7405-2_19"},{"key":"e_1_2_2_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(90)90145-4"},{"key":"e_1_2_2_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0174-173X(86)80005-X"}],"container-title":["Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806305011977?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806305011977?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2005.08.034","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.arthro.2005.08.034","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2005.08.034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T09:24:23Z","timestamp":1773566663000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.arthro.2005.08.034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":39,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["10.1016\/j.arthro.2005.08.034"],"URL":"https:\/\/doi.org\/10.1016\/j.arthro.2005.08.034","archive":["Portico"],"relation":{},"ISSN":["0749-8063","1526-3231"],"issn-type":[{"value":"0749-8063","type":"print"},{"value":"1526-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11]]}}}