{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T10:48:08Z","timestamp":1773571688170,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["arthroscopyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The purpose of this systematic review was to determine the effectiveness of cell\u2010based therapy for articular cartilage defects of the knee.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a literature search in Medline (1994 to 2009) regarding cell\u2010based therapies for chondral lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 10 Level I or II randomized controlled trials and 3 Level II prospective comparative studies. Although many of these studies had substantial flaws, which could introduce bias, we overall found no difference between the cell\u2010based studies and other interventions. In addition, we identified 26 Level III and IV studies of cell\u2010based therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There is insufficient evidence from the studies included in this review to say whether cell\u2010based therapy is superior to other treatment strategies in articular cartilage lesions of the knee.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2009.02.007","type":"journal-article","created":{"date-parts":[[2009,5,2]],"date-time":"2009-05-02T06:09:01Z","timestamp":1241244541000},"page":"531-552","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Cell\u2010Based Therapy in Articular Cartilage Lesions of the Knee"],"prefix":"10.1002","volume":"25","author":[{"given":"Norimasa","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of 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