{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:49:57Z","timestamp":1791607797860,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,8,11]],"date-time":"2011-08-11T00:00:00Z","timestamp":1313020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2011,8,11]],"date-time":"2011-08-11T00:00:00Z","timestamp":1313020800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2011,8,11]],"date-time":"2011-08-11T00:00:00Z","timestamp":1313020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,8,11]],"date-time":"2011-08-11T00:00:00Z","timestamp":1313020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["arthroscopyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The aim of our study is to compare the efficacy of platelet\u2010rich plasma (PRP) and viscosupplementation (hyaluronic acid [HA]) intra\u2010articular injections for the treatment of knee cartilage degenerative lesions and osteoarthritis (OA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study involved 150 patients affected by cartilage degenerative lesions and early and severe OA. Fifty symptomatic patients were treated with 3 autologous PRP intra\u2010articular injections and were evaluated prospectively at enrollment and at 2\u2010 and 6\u2010month follow\u2010up. The results obtained were compared with 2 homogeneous groups of patients treated with HA injections. One group was treated with injections of high\u2013molecular weight HA; the other group was treated with low\u2013molecular weight (LW) HA. International Knee Documentation Committee and EQ VAS scores were used for clinical evaluation; adverse events and patient satisfaction were also recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 2 months' follow\u2010up, the PRP and LW HA groups showed a similar improvement, with higher results compared with the high\u2013molecular weight HA group (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .005). At 6 months' follow\u2010up, better results were observed in the PRP group (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .005). PRP and LW HA treatments offered similar results in patients aged over 50 years and in the treatment of advanced OA. PRP showed a better performance compared with HA in younger patients affected by cartilage lesions or early OA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Autologous PRP injections showed more and longer efficacy than HA injections in reducing pain and symptoms and recovering articular function. Better results were achieved in younger and more active patients with a low degree of cartilage degeneration, whereas a worse outcome was obtained in more degenerated joints and in older patients, in whom results similar to those of viscosupplementation have been observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level II, prospective comparative study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2011.05.011","type":"journal-article","created":{"date-parts":[[2011,8,14]],"date-time":"2011-08-14T15:01:07Z","timestamp":1313334067000},"page":"1490-1501","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":461,"title":["Platelet\u2010Rich Plasma Intra\u2010Articular Injection Versus Hyaluronic Acid Viscosupplementation as Treatments for Cartilage Pathology: From Early Degeneration to Osteoarthritis"],"prefix":"10.1002","volume":"27","author":[{"given":"Elizaveta","family":"Kon","sequence":"first","affiliation":[{"name":"Biomechanics Laboratory\u2013III Clinic Rizzoli Orthopaedic Institute Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Mandelbaum","sequence":"additional","affiliation":[{"name":"Santa Monica Orthopaedic and Sports Medicine Group Santa Monica California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Buda","sequence":"additional","affiliation":[{"name":"II Clinic Rizzoli Orthopaedic Institute Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Filardo","sequence":"additional","affiliation":[{"name":"Biomechanics Laboratory\u2013III Clinic Rizzoli Orthopaedic Institute Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Delcogliano","sequence":"additional","affiliation":[{"name":"Biomechanics Laboratory\u2013III Clinic Rizzoli Orthopaedic Institute Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Timoncini","sequence":"additional","affiliation":[{"name":"II Clinic Rizzoli Orthopaedic Institute Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Maria","family":"Fornasari","sequence":"additional","affiliation":[{"name":"Immunohematology and Transfusion Medicine Service Rizzoli Orthopaedic Institute Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Giannini","sequence":"additional","affiliation":[{"name":"II Clinic Rizzoli Orthopaedic Institute Bologna 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