{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:02:14Z","timestamp":1790370134928,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T00:00:00Z","timestamp":1399593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T00:00:00Z","timestamp":1399593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the efficacy of low\u2010molecular\u2010weight heparin (LMWH) venous thromboprophylaxis in patients with transient reduced mobility in the non\u2010major orthopaedic setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A meta\u2010analysis was conducted using data from all available randomized trials comparing LMWH with placebo or no prophylactic treatment in patients with leg immobilization for fracture or soft\u2010tissue injury of the lower limb or in patients undergoing knee arthroscopy. The primary endpoint was the incidence of major venous thromboembolic events (VTEs), including asymptomatic proximal deep\u2010vein thrombosis, symptomatic VTEs, and VTE\u2010related death. The Mantel\u2010Haenszel method was used to generate the summary statistics for the overall effect of LMWH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fourteen studies were included (4,726 patients). The weighted rate of major VTEs was estimated to be 2.9% (95% confidence interval [CI], 2.2% to 3.7%) without LMWH prophylaxis. Overall, a significant 68% reduction in the risk of major VTEs was observed with LMWH prophylaxis (relative risk [RR], 0.32; 95% CI, 0.20 to 0.51;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001). The treatment effect was not modified by the clinical setting, that is, distal lower limb injury (7 studies; 1,711 patients; RR, 0.42; 95% CI, 0.20 to 0.86) or knee arthroscopy (6 studies; 2,428 patients; RR, 0.27; 95% CI, 0.15 to 0.49). A nonsignificant 35% increase in the risk of major bleeding was observed in the LMWH prophylaxis group (RR, 1.35; 95% CI, 0.53 to 3.47).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This meta\u2010analysis indicates potential efficacy of LMWH in preventing thromboembolic events in patients with reduced mobility in the non\u2010major orthopaedic setting compared with placebo or no treatment. However, the decision of whether to implement LMWH prophylaxis in each specific setting should also take into account the risk of VTEs in the absence of prophylaxis, the potential adverse effects of LMWH, and the cost.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level II, meta\u2010analysis of Level II studies or Level I studies with inconsistent results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2014.03.009","type":"journal-article","created":{"date-parts":[[2014,5,10]],"date-time":"2014-05-10T10:30:19Z","timestamp":1399717819000},"page":"987-996","source":"Crossref","is-referenced-by-count":41,"title":["Prevention of Venous Thromboembolic Events With Low\u2010Molecular\u2010Weight Heparin in the Non\u2010Major Orthopaedic Setting: Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1002","volume":"30","author":[{"given":"C\u00e9line","family":"Chapelle","sequence":"first","affiliation":[{"name":"INSERM, CIC1408 CHU Saint\u2010Etienne Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Rosencher","sequence":"additional","affiliation":[{"name":"H\u00f4pital de Cochin (AP\u2010HP) Anesth\u00e9sie\u2010R\u00e9animation Universit\u00e9 Paris Descartes, F\u201075014 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Jacques Zufferey","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019Anesth\u00e9sie\u2010R\u00e9animation CHU Saint\u2010Etienne Saint\u2010Etienne France"},{"name":"EA3065, Universit\u00e9 Jean\u2010Monnet F\u201042023 Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Mismetti","sequence":"additional","affiliation":[{"name":"INSERM, CIC1408 CHU Saint\u2010Etienne Saint\u2010Etienne France"},{"name":"Unit\u00e9 de Recherche Clinique Innovation et Pharmacologie CHU Saint\u2010Etienne, F\u201042055 Saint\u2010Etienne France"},{"name":"EA3065, Universit\u00e9 Jean\u2010Monnet F\u201042023 Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Cucherat","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacologie Clinique Universit\u00e9 de Lyon, F\u201069376 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvy","family":"Laporte","sequence":"additional","affiliation":[{"name":"INSERM, CIC1408 CHU Saint\u2010Etienne Saint\u2010Etienne France"},{"name":"Unit\u00e9 de Recherche Clinique Innovation et Pharmacologie CHU Saint\u2010Etienne, F\u201042055 Saint\u2010Etienne France"},{"name":"EA3065, Universit\u00e9 Jean\u2010Monnet F\u201042023 Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Meta\u2010Embol Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,9]]},"reference":[{"key":"e_1_2_3_2_2","unstructured":"Soci\u00e9t\u00e9 Fran\u00e7aise d'Anesth\u00e9sie et de R\u00e9animation. Pr\u00e9vention de la maladie thromboembolique veineuse p\u00e9riop\u00e9ratoire et obst\u00e9tricale. Available from:http:\/\/www.sfar.org\/_docs\/articles\/preventionmte_rpc.pdf. Accessed April 18 2014."},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0656"},{"key":"e_1_2_3_4_2","unstructured":"National Institute for Health and Clinical Excellence. Venous thromboembolic diseases: The management of venous thromboembolic diseases and the role of thrombophilia testing. Available from: URL:http:\/\/www.nice.org.uk\/nicemedia\/live\/13767\/59720\/59720.pdf. Published June 2012. Accessed February 14 \u00a02013."},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annfar.2011.10.008"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_3_7_2","unstructured":"European Medicines Agency. Committee for Proprietary Medicinal Products. Points to consider on clinical investigation of medicinal products for prophylaxis of intra\u2010 and post\u2010operative venous thromboembolic risk. Available from: URL:http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Scientific_guideline\/2009\/09\/WC500003301.pdf. Published 2009. Accessed February 14 \u00a02013."},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7121.1533"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(00)00242-0"},{"key":"e_1_2_3_10_2","first-page":"20","article-title":"Incidence and prophylaxis of deep venous thrombosis in outpatients with injury of the lower limb","volume":"23","author":"Kujath P.","year":"1993","journal-title":"Haemostasis"},{"key":"e_1_2_3_11_2","first-page":"345","article-title":"Thromboembolieprophylaxe bei ambulant durchgef\u00fchrten arthroskopischen Meniskusoperationen","volume":"5","author":"Roth V.P.","year":"1995","journal-title":"Orthop Prax"},{"key":"e_1_2_3_12_2","unstructured":"Canata GL Chiey A. Prevention of venous thromboembolism after ACL reconstruction: A prospective randomized study. Presented at the International Society of Arthroscopy Knee Surgery and Orthopedic Sports Medicine Congress; Auckland New Zealand; March 10\u201013 \u00a02003."},{"key":"e_1_2_3_13_2","doi-asserted-by":"crossref","unstructured":"Selby R Geerts WH Kreder HJ et\u00a0al. Clinically\u2010important venous thromboembolism (CIVTE) following isolated leg fractures distal to the knee: Epidemiology and prevention: The D\u2010KAF (Dalteparin in Knee to Ankle Fracture) trial. Presented at the XXI International Society on Thrombosis and Haemostasis Congress; Geneva Switzerland; July 6\u201012 \u00a02007.","DOI":"10.1111\/j.1538-7836.2007.tb01708.x"},{"key":"e_1_2_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91320-3"},{"key":"e_1_2_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(02)00059-2"},{"key":"e_1_2_3_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011327"},{"key":"e_1_2_3_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.bot.0000250741.65003.14"},{"key":"e_1_2_3_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/17453670710014185"},{"key":"e_1_2_3_19_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.91B3.20820"},{"key":"e_1_2_3_20_2","doi-asserted-by":"publisher","DOI":"10.1053\/jars.2001.21247"},{"key":"e_1_2_3_21_2","doi-asserted-by":"publisher","DOI":"10.1053\/jars.2002.30013"},{"key":"e_1_2_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2007.02.001"},{"key":"e_1_2_3_23_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-149-2-200807150-00003"},{"key":"e_1_2_3_24_2","first-page":"CD005259","article-title":"Interventions for preventing venous thromboembolism in adults undergoing knee arthroscopy","author":"Ramos J.","year":"2008","journal-title":"Cochrane Database Syst Rev."},{"key":"e_1_2_3_25_2","first-page":"CD006681","article-title":"Low molecular weight heparin for prevention of venous thromboembolism in patients with lower\u2010leg immobilization","author":"Testroote M.","year":"2008","journal-title":"Cochrane Database Syst Rev."},{"key":"e_1_2_3_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.02984.x"},{"key":"e_1_2_3_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001130050231"},{"key":"e_1_2_3_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12395"}],"container-title":["Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806314002333?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806314002333?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2014.03.009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.arthro.2014.03.009","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2014.03.009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T09:00:21Z","timestamp":1773565221000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.arthro.2014.03.009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,9]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1016\/j.arthro.2014.03.009"],"URL":"https:\/\/doi.org\/10.1016\/j.arthro.2014.03.009","archive":["Portico"],"relation":{},"ISSN":["0749-8063","1526-3231"],"issn-type":[{"value":"0749-8063","type":"print"},{"value":"1526-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,9]]}}}