{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:30:34Z","timestamp":1787700634111,"version":"build-2784847793"},"reference-count":70,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T00:00:00Z","timestamp":1404345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T00:00:00Z","timestamp":1404345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>We aimed to determine the rate of local recurrence, the rate of postoperative complications, and the functional outcome at final follow\u2010up of surgical and nonsurgical treatment approaches for pigmented villonodular synovitis (PVNS) of the knee.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medline, Embase, and the Cochrane Library were systematically searched for studies that reported the results of treatment for any type of PVNS between January 1, 1950, and August 1, 2013. Two authors extracted the data independently using predefined data fields including study quality indicators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty studies (1,019 patients) met the inclusion criteria. Thirty\u2010five presented data on the treatment of localized pigmented villonodular synovitis (LPVNS), 40 on diffuse pigmented villonodular synovitis (DPVNS), 1 on extra\u2010articular LPVNS, and 7 on DPVNS with extra\u2010articular involvement. Many therapeutic options were reported. Depending on these options, DPVNS recurred in 8% to 70% of the series and LPVNS recurred in 0% to 8% of the series. For LPVNS, the 2 most\u2010reported options were open localized synovectomy and arthroscopic local synovectomy. Between these 2 courses of treatment, no difference was found in terms of local recurrence (8.7% for open synovectomy and 6.9% for arthroscopic synovectomy) and postoperative complications (&lt;1% for open synovectomy and 0% for arthroscopic synovectomy). For DPVNS, the 2 most\u2010reported options were open total synovectomy and arthroscopic total synovectomy. Between these 2 courses of treatment, no difference was found in terms of local recurrence (22.6% for open synovectomy and 16.1% for arthroscopic synovectomy). However, we found a lower rate of reported complications between open synovectomy (19.3%) and arthroscopic synovectomy (0%). Internal irradiation or external beam radiation as an adjuvant treatment to surgical synovectomy seemed to decrease the rate of local recurrence in DPVNS cases with a high risk of recurrence. Finally, we found a great heterogeneity in the way the functional results were reported, and no valid conclusion could be made based on the data we extracted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found no difference in local recurrence rates after open or arthroscopic surgery for either LPVNS or DPVNS. However, a lower rate of postoperative complications was reported after arthroscopic surgery for DPVNS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level IV, systematic review of Level IV therapeutic studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2014.04.101","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T21:45:23Z","timestamp":1404423923000},"page":"1327-1341","source":"Crossref","is-referenced-by-count":89,"title":["Treatment of Pigmented Villonodular Synovitis of the Knee"],"prefix":"10.1002","volume":"30","author":[{"given":"Jean\u2010Charles","family":"Aur\u00e9gan","sequence":"first","affiliation":[{"name":"H\u00f4pitaux Universitaires Paris Ile\u2010de\u2010France Ouest Assistance Publique \u2013 H\u00f4pitaux de Paris Boulogne\u2010Billancourt France"},{"name":"Universit\u00e9 de Versailles Saint\u2010Quentin\u2010en\u2010Yvelines nit\u00e9 de Formation et de Recherche des Sciences de la Sant\u00e9 Versailles France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahnaz","family":"Klouche","sequence":"additional","affiliation":[{"name":"H\u00f4pitaux Universitaires Paris Ile\u2010de\u2010France Ouest Assistance Publique \u2013 H\u00f4pitaux de Paris Boulogne\u2010Billancourt France"},{"name":"Institut de l\u2019Appareil Locomoteur Nollet Paris France"},{"name":"Clinique du Sport Paris V Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoann","family":"Bohu","sequence":"additional","affiliation":[{"name":"H\u00f4pitaux Universitaires Paris Ile\u2010de\u2010France Ouest Assistance Publique \u2013 H\u00f4pitaux de Paris Boulogne\u2010Billancourt France"},{"name":"Institut de l\u2019Appareil Locomoteur Nollet Paris France"},{"name":"Clinique du Sport Paris V Paris 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