{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T07:15:51Z","timestamp":1788160551890,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T00:00:00Z","timestamp":1404345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T00:00:00Z","timestamp":1404345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The purpose of this study was to evaluate the efficacy of periarticular multimodal drug injection after medial opening\u2010wedge high tibial osteotomy regarding the postoperative pain level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From January 2011 to January 2012, 70 patients underwent medial opening\u2010wedge high tibial osteotomy. Thirty\u2010five patients were randomly assigned to receive no injection (group I), and 35 patients were assigned to receive periarticular multimodal drug injection (group II). These 2 groups were compared regarding the postoperative pain level, frequency of additional nonsteroidal anti\u2010inflammatory drug injections, total amount of patient\u2010controlled analgesia, and number of times that patients pushed the patient\u2010controlled analgesia button at each time interval. Statistical results were based on multivariate analysis of variance and repeated\u2010measures analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multivariate analysis of variance of mean visual analog scale (VAS) scores over the 2\u2010week postoperative period showed statistical significance (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001). Repeated\u2010measures analysis yielded a statistically significant difference (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .001) for the time\u2010by\u2010treatment interaction, showing a clear periarticular multimodal drug injection benefit over time based on VAS scores. In addition, the mean number of times that patients pushed the patient\u2010controlled analgesia button differed significantly between groups over time (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .01). The VAS scores, frequency of additional nonsteroidal anti\u2010inflammatory drug injections, mean number of times that patients pushed the patient\u2010controlled analgesia button, and mean total amount of fentanyl consumption differed significantly within each group over time (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001 for all variables). However, the frequency of additional nonsteroidal anti\u2010inflammatory drug injections and mean total amount of fentanyl consumption did not differ significantly between groups over time (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .822,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .529, and\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .282). Opioid\u2010 and injection\u2010related complications were not found.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This prospective randomized study shows that intraoperative periarticular multimodal drug injections in patients undergoing medial opening\u2010wedge high tibial osteotomy for unicompartmental osteoarthritis of the knee could result in significant reductions in VAS scores at 2\u00a0weeks postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level I, high\u2010quality randomized controlled trial with statistically significant differences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2014.04.104","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T11:19:52Z","timestamp":1404386392000},"page":"1261-1268","source":"Crossref","is-referenced-by-count":17,"title":["Efficacy of Periarticular Multimodal Drug Injection After Medial Opening\u2010Wedge High Tibial Osteotomy: A\u00a0Randomized, Controlled Study"],"prefix":"10.1002","volume":"30","author":[{"given":"Woon\u2010Hwa","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Murup Hospital Gyeongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryohei","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Yokosuka Municipal Hospital Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung\u2010Woo","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Murup Hospital Gyeongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Su","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Murup Hospital Gyeongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae\u2010Hun","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Murup Hospital Gyeongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Hyae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Murup Hospital Gyeongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae\u2010Heon","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Murup Hospital Gyeongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,3]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2009.02196.x"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-013-2928-4"},{"key":"e_1_2_2_4_2","unstructured":"Teng Y Jiang J Chen S et\u00a0al. Periarticular multimodal drug injection in total knee arthroplasty.KneeSurg Sports Traumatol Arthroscin press available online 20 June 2013.http:\/\/doi.org\/10.1007\/s00167\u2010013\u20102566\u20100."},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.E.00344"},{"key":"e_1_2_2_6_2","unstructured":"Cho CH Song KS Min BW Jung GH Lee YK Shin HK. 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