{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:25:29Z","timestamp":1787739929857,"version":"build-2784847793"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T00:00:00Z","timestamp":1407283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T00:00:00Z","timestamp":1407283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study compared the clinical results and second\u2010look arthroscopic findings of patients undergoing open\u2010wedge high tibial osteotomy (HTO) for varus deformity, with or without mesenchymal stem cell (MSC) therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, comparative observational study was designed to evaluate the effectiveness of MSC therapy. The patients were divided into 2 groups: HTO with platelet\u2010rich plasma (PRP) injection only (n\u00a0= 23) or HTO in conjunction with MSC therapy and PRP injection (n\u00a0= 21). Prospective evaluations of both groups were performed using the Lysholm score, Knee Injury and Osteoarthritis Outcome Score (KOOS), and a visual analog scale (VAS) score for pain. Second\u2010look arthroscopy was carried out in all patients at the time of metal removal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The patients in the MSC\u2010PRP group showed significantly greater improvements in the KOOS subscales for pain (PRP only, 74.0 \u00b1 5.7; MSC\u2010PRP, 81.2 \u00b1 6.9;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001) and symptoms (PRP only, 75.4 \u00b1 8.5; MSC\u2010PRP, 82.8 \u00b1 7.2;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .006) relative to the PRP\u2010only group. Although the mean Lysholm score was similarly improved in both groups (PRP only, 80.6 \u00b1 13.5; MSC\u2010PRP, 84.7 \u00b1 16.2;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .357), the MSC\u2010PRP group showed a significantly greater improvement in the VAS pain score (PRP only, 16.2 \u00b1 4.6; MSC\u2010PRP, 10.2 \u00b1 5.7;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001). There were no differences in the preoperative (PRP only, varus 2.8\u00b0 \u00b1 1.7\u00b0; MSC\u2010PRP, varus 3.4\u00b0 \u00b1 3.0\u00b0;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .719) and postoperative (PRP only, valgus 9.8\u00b0 \u00b1 2.4\u00b0; MSC\u2010PRP, valgus 8.7\u00b0 \u00b1 2.3\u00b0;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .678) femorotibial angles or weight\u2010bearing lines between the groups. Arthroscopic evaluation, at plate removal, showed that partial or even fibrocartilage coverage was achieved in 50% of the MSC\u2010PRP group patients but in only 10% of the patients in the PRP\u2010only group (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MSC therapy, in conjunction with HTO, mildly improved cartilage healing and showed good clinical results in some KOOS subscores and the VAS pain score compared with PRP only.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level II, prospective comparative study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2014.05.036","type":"journal-article","created":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T08:45:23Z","timestamp":1407314723000},"page":"1453-1460","source":"Crossref","is-referenced-by-count":192,"title":["Comparative Outcomes of Open\u2010Wedge High Tibial Osteotomy With Platelet\u2010Rich Plasma Alone or in Combination With Mesenchymal Stem Cell Treatment: A Prospective Study"],"prefix":"10.1002","volume":"30","author":[{"given":"Yong\u2010Gon","family":"Koh","sequence":"first","affiliation":[{"name":"Center for Stem Cell &amp; Arthritis Research Department of Orthopaedic Surgery Yonsei Sarang Hospital Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oh\u2010Ryong","family":"Kwon","sequence":"additional","affiliation":[{"name":"Center for Stem Cell &amp; Arthritis Research Department of Orthopaedic Surgery Yonsei Sarang Hospital Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Sang","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Stem Cell &amp; Arthritis Research Department of Orthopaedic Surgery Yonsei Sarang Hospital Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Jin","family":"Choi","sequence":"additional","affiliation":[{"name":"Center for Stem Cell &amp; Arthritis Research Department of Orthopaedic Surgery Yonsei Sarang Hospital Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,6]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/JSA.0b013e3180303592"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509360403"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2007.06.008"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/jars.2002.35258"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000132625.05916.48"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2012.04.001"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2012.11.017"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200406000-00004"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.1998.28.2.88"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.73B6.1955438"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(18)30474-1"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/107632701300062859"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2011.0072"},{"key":"e_1_2_2_15_2","unstructured":"ICRS Cartilage Injury Evaluation Package. International Cartilage Repair Society. Available at:http:\/\/www.cartilage.org\/_files\/contentmanagement\/ICRS_evaluation.pdf. Published January 2000. Updated April 28 2000."},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00132-003-0593-0"},{"key":"e_1_2_2_17_2","first-page":"248","article-title":"Preoperative planning for high tibial osteotomy. The effect of lateral tibiofemoral separation and tibiofemoral length","author":"Dugdale T.W.","year":"1992","journal-title":"Clin Orthop Relat Res."},{"key":"e_1_2_2_18_2","unstructured":"Koh YG Choi YJ Kwon SK Kim YS Yeo JE. Clinical results and second\u2010look arthroscopic findings after treatment with adipose\u2010derived stem cells for knee osteoarthritis.Knee Surg Sports Traumatol Arthroscin press available online 11 December 2013.doi:10.1007\/s00167\u2010013\u20102807\u20102."},{"key":"e_1_2_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2007.05.018"},{"key":"e_1_2_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-5898(20)30753-7"},{"key":"e_1_2_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00266324"},{"key":"e_1_2_2_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546503259301"},{"key":"e_1_2_2_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546508328414"},{"key":"e_1_2_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20886"},{"key":"e_1_2_2_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-30-9"},{"key":"e_1_2_2_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-005-0430-z"},{"key":"e_1_2_2_27_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0589"},{"key":"e_1_2_2_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-003-0490-3"},{"key":"e_1_2_2_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-7-29"},{"key":"e_1_2_2_30_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546513479018"},{"key":"e_1_2_2_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar4156"},{"key":"e_1_2_2_32_2","doi-asserted-by":"publisher","DOI":"10.1089\/biores.2013.0024"},{"key":"e_1_2_2_33_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.43B4.752"}],"container-title":["Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806314004964?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806314004964?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2014.05.036","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.arthro.2014.05.036","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2014.05.036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T09:01:49Z","timestamp":1773565309000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.arthro.2014.05.036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,6]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1016\/j.arthro.2014.05.036"],"URL":"https:\/\/doi.org\/10.1016\/j.arthro.2014.05.036","archive":["Portico"],"relation":{},"ISSN":["0749-8063","1526-3231"],"issn-type":[{"value":"0749-8063","type":"print"},{"value":"1526-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,6]]}}}