{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:26:21Z","timestamp":1785515181541,"version":"3.56.0"},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T00:00:00Z","timestamp":1415836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T00:00:00Z","timestamp":1415836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T00:00:00Z","timestamp":1415836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["arthroscopyjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The purpose of this study was to perform a systematic review, meta\u2010analysis, and meta\u2010regression of all Level I and Level II studies comparing the clinical or structural outcomes, or both, after rotator cuff repair with and without platelet\u2010rich product (PRP) supplementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A literature search of the PubMed and EMBASE databases was performed to identify all Level I or II studies comparing the clinical or structural outcomes, or both, after arthroscopic repair of full\u2010thickness rotator cuff tears with (PRP+ group) and without (PRP\u2212 group) PRP supplementation. Data included outcome scores (American Shoulder and Elbow Surgeons [ASES], University of California Los Angeles [UCLA], Constant, Simple Shoulder Test [SST] and visual analog scale [VAS] scores) and retears diagnosed with imaging studies. Meta\u2010analyses compared preoperative, postoperative, and gain in outcome scores and relative risk ratios for\u00a0retears. Meta\u2010regression compared the effect of PRP treatment on outcome scores and retear rates according to 6\u00a0covariates. Minimum effect sizes that were detectable with 80% power were also calculated for each study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eleven studies were included in this review and a maximum of 8 studies were used for meta\u2010analyses according to data availability. There were\u00a0no statistically significant differences between the PRP+ and PRP\u2212 groups for overall outcome scores or retear rates (\n                      <jats:italic>P<\/jats:italic>\n                      &gt; .05). Overall gain in the Constant score was decreased when liquid PRP was injected over the tendon surface compared with PRP application at the tendon\u2010bone interface (\u22126.88 points\n                      <jats:italic>v<\/jats:italic>\n                      \u00a0+0.78 points, respectively;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .046); however, this difference did not reach the previously reported minimum clinically important difference (MCID) for Constant scores. When the initial tear size was greater than 3\u00a0cm in anterior\u2010posterior length, the PRP+ group exhibited decreased retear rates after double\u2010row repairs when compared with the PRP\u2013 group (25.9%\n                      <jats:italic>v<\/jats:italic>\n                      57.1%, respectively;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.046). Sensitivity power analyses revealed that most included studies were only powered to detect large differences in outcome scores between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There were no statistically significant differences in overall gain in outcome scores or retear rates between treatment groups. Gain in Constant scores was significantly increased when PRPs were applied at the tendon\u2010bone interface when compared with application over the top of the repaired tendon. Retear rates were significantly decreased when PRPs were used for the treatment of tears greater than 3\u00a0cm in anterior\u2010posterior length using a double\u2010row technique. Most of the included studies were only powered to detect large differences in outcome scores between treatment groups. In addition, an\u00a0increased risk for selection, performance, and attrition biases was found.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level II, meta\u2010analysis of Level I and Level II studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2014.09.007","type":"journal-article","created":{"date-parts":[[2014,11,16]],"date-time":"2014-11-16T21:15:20Z","timestamp":1416172520000},"page":"306-320","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":143,"title":["Clinical and Structural Outcomes After Arthroscopic Repair of\u00a0Full\u2010Thickness Rotator Cuff Tears With and Without Platelet\u2010Rich Product Supplementation: A\u00a0Meta\u2010analysis and\u00a0Meta\u2010regression"],"prefix":"10.1002","volume":"31","author":[{"given":"Ryan J.","family":"Warth","sequence":"first","affiliation":[{"name":"Steadman Philippon Research Institute Vail Colorado U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant J.","family":"Dornan","sequence":"additional","affiliation":[{"name":"Steadman Philippon Research Institute Vail Colorado U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan W.","family":"James","sequence":"additional","affiliation":[{"name":"Steadman Philippon Research Institute Vail Colorado U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilee P.","family":"Horan","sequence":"additional","affiliation":[{"name":"Steadman Philippon Research Institute Vail Colorado U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Millett","sequence":"additional","affiliation":[{"name":"Steadman Philippon Research Institute Vail Colorado U.S.A."},{"name":"The Steadman Clinic Vail Colorado U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,13]]},"reference":[{"key":"e_1_2_3_2_2","unstructured":"Boyer P Bouthors C Delcourt T et\u00a0al. 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