{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T21:42:22Z","timestamp":1788644542744,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T00:00:00Z","timestamp":1428883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T00:00:00Z","timestamp":1428883200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T00:00:00Z","timestamp":1428883200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["2012044586"],"award-info":[{"award-number":["2012044586"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["2012044586"],"award-info":[{"award-number":["2012044586"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","arthroscopyjournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate whether non\u2010autologous transplantation of human umbilical cord blood\u2013derived mesenchymal stem cells (hUCB\u2010MSCs) could be integrated safely at the bone\u2010tendon junction without immune rejection and could enhance bone\u2010tendon healing effectively during anterior cruciate ligament (ACL) reconstruction in an animal model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>ACL reconstructions using hamstring tendons were performed in 30 adult rabbits. The bone tunnels were treated with hUCB\u2010MSCs or were untreated. The specimens were harvested at 4, 8, and 12 weeks. We performed a gross examination of the knee joint; a histologic assessment using H&amp;E staining, as well as immunohistochemical staining, for type II collagen; and an evaluation of bone tunnel widening using micro\u2013computed tomography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No evidence of immune rejection was detected. Tendon\u2010bone healing through Sharpey\u2010like fibers was noticed around tendon grafts at 12 weeks in the control group. A smooth transition from bone to tendon through broad fibrocartilage formation was identified in the treatment group, and the interface zone showed abundant type II collagen production on immunohistochemical staining. Histologic scores for bone\u2010tendon healing were significantly higher in the treatment group at all time points (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001). Micro\u2013computed tomography at 12 weeks showed a significantly smaller tibial (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .029) and femoral (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .033) bone tunnel enlargement in the treated group than in the control group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Non\u2010autologous transplantation of hUCB\u2010MSCs was applied in ACL reconstruction without early immune rejection. There was enhanced tendon\u2010bone healing through broad fibrocartilage formation with higher histologic scores and decreased femoral and tibial tunnel widening compared with the control group (79.2% and 80%, respectively, of the control group tunnel area at 12 weeks).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>Non\u2010autologous transplantation of hUCB\u2010MSCs has therapeutic potential in promoting tendon\u2010to\u2010bone healing after ACL reconstruction. Further study in the human model is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2015.02.023","type":"journal-article","created":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T19:07:54Z","timestamp":1429124874000},"page":"1530-1539","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"title":["Efficacy and Safety of Human Umbilical Cord Blood\u2013Derived Mesenchymal Stem Cells in Anterior Cruciate Ligament Reconstruction of a Rabbit Model: New Strategy to Enhance Tendon Graft Healing"],"prefix":"10.1002","volume":"31","author":[{"given":"Ki\u2010Mo","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Anam Hospital Korea University School of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Chul","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Guro 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