{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T20:31:55Z","timestamp":1773606715199,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T00:00:00Z","timestamp":1450742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T00:00:00Z","timestamp":1450742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T00:00:00Z","timestamp":1450742400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","arthroscopyjournal.org","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the fixation integrity at time zero of a type I\/III collagen patch secured to a chondral defect in the porcine knee using methods typically employed in autologous chondrocyte implantation (ACI) and matrix\u2010assisted chondrocyte implantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010four porcine knee specimens underwent a medial parapatellar arthrotomy. A prefabricated template was used to create cartilage defects of 2 cm\n                      <jats:sup>2<\/jats:sup>\n                      in the medial femoral condyle. A size\u2010matched collagen patch was fashioned. Four methods of fixation to the chondral defect were analyzed: group 1\u2014saline, group 2\u2014fibrin glue around the periphery of the patch, group 3\u2014fibrin glue applied to the base of the defect and around the periphery of the patch, group 4\u20146\u20100 vicryl suture and fibrin glue around the periphery of the patch. Collagen patch fixation was assessed at intervals of 60, 300, 600, 900, and 1,200 cycles from full extension to 90\u00b0 of flexion, performed manually without application of axial force. Patch fixation was evaluated by 2 independent observers using a customized scoring scale.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean peripheral detachment of the patch and chondral defect uncovering remained less than 25% for all groups. Area of defect uncovering was significantly increased in group 2 compared with group 4 after 900 and 1,200 cycles (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .0014 and\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .0025, respectively). Fibrin glue applied to the base of the defect, or suturing of the patch, reduced deformation significantly after 900 cycles.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Suture increases the stability of fixation of a type I\/III collagen patch to a chondral defect better than fibrin glue alone in the porcine knee after repetitive cycling, with respect to patch detachment and chondral defect uncovering. Application of fibrin glue to the base of the defect, or securing the patch with suture, decreases collagen patch deformation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>In cases where minimally invasive techniques do not allow suture fixation of the collagen patch, scaffold fixation may be compromised during articular motion protocols typically used after second\u2010 and third\u2010generation ACI procedures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2015.10.001","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T09:16:01Z","timestamp":1450775761000},"page":"820-827","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Comparison of Collagen Graft Fixation Methods in the Porcine Knee: Implications for Matrix\u2010Assisted Chondrocyte Implantation and Second\u2010Generation Autologous Chondrocyte Implantation"],"prefix":"10.1002","volume":"32","author":[{"given":"Graeme P.","family":"Whyte","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery New York University Hospital for Joint Diseases New York New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"McGee","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery New York University Hospital for Joint Diseases New York New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laith","family":"Jazrawi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery New York University Hospital for Joint Diseases New York New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Meislin","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery New York University Hospital for Joint Diseases New York New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,22]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199908000-00020"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v009a04"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.85B2.13543"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546511399382"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/1947603510392023"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200403000-00001"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546513516747"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546508322897"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2549"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.91B9.22490"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-010-1050-3"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.0246"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v6.i3.344"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2014.11.017"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0300"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100070208"},{"key":"e_1_2_2_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199410063311401"},{"key":"e_1_2_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2006.07.057"},{"key":"e_1_2_2_20_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.86B2.14324"},{"key":"e_1_2_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2005.08.009"},{"key":"e_1_2_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2006.02.011"},{"key":"e_1_2_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2009.12.028"},{"key":"e_1_2_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2006.12.003"},{"key":"e_1_2_2_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/1947603511435271"},{"key":"e_1_2_2_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546513510884"},{"key":"e_1_2_2_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546512463675"},{"key":"e_1_2_2_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546513518552"},{"key":"e_1_2_2_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546514523927"},{"key":"e_1_2_2_30_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509332258"},{"key":"e_1_2_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2009.09.001"},{"key":"e_1_2_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2005.11.007"},{"key":"e_1_2_2_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-011-1571-4"},{"key":"e_1_2_2_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-11-283"},{"key":"e_1_2_2_35_2","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_2_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-004-0535-3"},{"key":"e_1_2_2_37_2","doi-asserted-by":"publisher","DOI":"10.1177\/1947603510368055"},{"key":"e_1_2_2_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-011-0338-7"}],"container-title":["Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806315008117?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806315008117?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2015.10.001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.arthro.2015.10.001","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2015.10.001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T08:46:22Z","timestamp":1773564382000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.arthro.2015.10.001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,22]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1016\/j.arthro.2015.10.001"],"URL":"https:\/\/doi.org\/10.1016\/j.arthro.2015.10.001","archive":["Portico"],"relation":{},"ISSN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