{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:34:45Z","timestamp":1782488085941,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T00:00:00Z","timestamp":1461888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T00:00:00Z","timestamp":1461888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T00:00:00Z","timestamp":1461888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","arthroscopyjournal.org","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To describe T2 mapping values in arthroscopically determined International Cartilage Repair Society (ICRS) grades in damaged and healthy\u2010appearing articular cartilage waste specimens from arthroscopic femoroacetabular impingement (FAI) treatment. Furthermore, we sought to compare ICRS grades of the specimens with biochemical, immunohistochemistry and histologic endpoints and assess correlations with T2 mapping.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010four patients were prospectively enrolled, consecutively, between December 2011 and August 2012. Patients were included if they were aged 18\u00a0years or older and met criteria that followed the clinical indications for arthroscopy to treat FAI. Patients with prior hip trauma including fracture or dislocation or who have undergone prior hip surgery were excluded. All patients received a preoperative sagittal T2 mapping scan of the hip joint. Cartilage was graded intraoperatively using the ICRS grading system, and graded specimens were collected as cartilage waste for histologic, biochemical, and immunohistochemistry analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010four cartilage specimens (22 healthy\u2010appearing, 22 damaged) were analyzed. Median T2 values were significantly higher among damaged specimens (55.7 \u00b1 14.9\u00a0ms) than healthy\u2010appearing specimens (49.3 \u00b1 12.3\u00a0ms;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .043), which was most exaggerated among mild (grade 1 or 2) defects where the damaged specimens (58.1 \u00b1 16.4\u00a0ms) were significantly higher than their paired healthy\u2010appearing specimens (48.7 \u00b1 15.4\u00a0ms;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.026). Severely damaged specimens (grade 3 or 4) had significantly lower cumulative H&amp;E than their paired healthy\u2010appearing counterparts (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .02) but was not statistically significant among damaged specimens with mild (grade 1 or 2) defects (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .198). Among healthy\u2010appearing specimens, median T2 and the percentage of collagen fibers oriented parallel were significantly correlated (rho\u00a0= 0.425,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .048).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study outlines the potential for T2 mapping to identify early cartilage degeneration in patients undergoing arthroscopy to treat FAI. Findings in ICRS grade 1 and 2 degeneration corresponded to an increase in T2 values. Further biochemical evaluation revealed a significant difference between healthy\u2010appearing cartilage and late degeneration in cumulative H&amp;E as well as significantly lower percentage of collagen fibers oriented parallel and a higher percentage of collagen fibers oriented randomly when considering all grades of cartilage damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level II, prospective comparative study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2016.01.066","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T11:10:40Z","timestamp":1462014640000},"page":"1601-1611","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Prospective In\u00a0Vivo Comparison of Damaged and Healthy\u2010Appearing Articular Cartilage Specimens in Patients With Femoroacetabular Impingement: Comparison of T2 Mapping, Histologic Endpoints, and Arthroscopic Grading"],"prefix":"10.1002","volume":"32","author":[{"given":"Charles P.","family":"Ho","sequence":"first","affiliation":[{"name":"Steadman Philippon Research Institute Vail Colorado U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel K.","family":"Surowiec","sequence":"additional","affiliation":[{"name":"Steadman Philippon Research Institute Vail Colorado U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David D.","family":"Frisbie","sequence":"additional","affiliation":[{"name":"Orthopaedic Research Center Department of Clinical Sciences College of Veterinary Medicine and Biomedical Studies Colorado State University Fort Collins Colorado U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando P.","family":"Ferro","sequence":"additional","affiliation":[{"name":"Steadman Philippon Research Institute Vail Colorado U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine J.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Steadman Philippon Research Institute Vail Colorado U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana J.","family":"Saroki","sequence":"additional","affiliation":[{"name":"Steadman Philippon Research Institute Vail Colorado U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric K.","family":"Fitzcharles","sequence":"additional","affiliation":[{"name":"Steadman Philippon Research Institute Vail Colorado U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant J.","family":"Dornan","sequence":"additional","affiliation":[{"name":"Steadman Philippon Research Institute Vail Colorado U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc J.","family":"Philippon","sequence":"additional","affiliation":[{"name":"Steadman Philippon Research 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