{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T18:32:41Z","timestamp":1785177161030,"version":"3.55.0"},"reference-count":61,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,7,31]],"date-time":"2016-07-31T00:00:00Z","timestamp":1469923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,7,31]],"date-time":"2016-07-31T00:00:00Z","timestamp":1469923200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2016,7,31]],"date-time":"2016-07-31T00:00:00Z","timestamp":1469923200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","arthroscopyjournal.org","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare microfracture (MFX) and osteochondral autograft transfer (OAT) surgical techniques to determine (1) postoperative activity level, (2) subjective patient outcomes, (3) failure rates, and (4) assess if any lesion characteristics favored one technique over the other.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive review of literature was performed of all studies comparing MFX and OAT. Studies included were all prospective studies that reported on activity\u2010based outcome measures such as Tegner activity scores and subjective outcomes such as the International Knee Documentation Committee score. Failure rates, as determined by the publishing authors, were recorded for each study. Meta\u2010analyses were conducted using a random\u2010effects model. Paired standardized mean differences (Hedges's g to account for small sample bias) were used for continuous outcome measures, and risk ratios (Mantel\u2010Haenszel method for small sample bias) for dichotomous outcome measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Six prospective studies satisfied the eligibility criteria and included 249 patients (186 male, 120 female) with an average age of 26.4\u00a0years and follow\u2010up of 67.2\u00a0months. Tegner scores were superior in patients treated with OAT compared with MFX (\u0394OAT\u2010MFX for pre\u2010post scores\u00a0= 0.94 Tegner points, standardized mean difference [SMD]\u00a0= 0.469,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .005). Failure rates of MFX were higher than OAT (OAT\u00a0= 11%, MFX\u00a0= 32%, risk ratio\u00a0= 2.42,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .036). OAT was superior to MFX at 3\u00a0years in relation to subjective outcome scores (SMD\u00a0= 0.404,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .008). When assessing OAT lesions larger than 3\u00a0cm\n                      <jats:sup>2<\/jats:sup>\n                      , OAT was superior to MFX with respect to activity level (SMD\u00a0= 0.506,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      OAT may achieve higher activity levels and lower risk of failure when compared with MFX for cartilage lesions greater than 3\u00a0cm\n                      <jats:sup>2<\/jats:sup>\n                      in the knee, although there was no significant difference for lesions less than 3\u00a0cm\n                      <jats:sup>2<\/jats:sup>\n                      at midterm. However, because of variability in patient\u2010specific factors such as age, preinjury activity level, lesion location and size, the superiority of OAT over MFX cannot be generalized to all patient populations and therefore requires individualized patient care.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level II, meta\u2010analysis of Level I and II studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2016.05.038","type":"journal-article","created":{"date-parts":[[2016,7,31]],"date-time":"2016-07-31T15:06:10Z","timestamp":1469977570000},"page":"2118-2130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Osteochondral Autograft Transfer Versus Microfracture in the Knee: A Meta\u2010analysis of Prospective Comparative Studies at Midterm"],"prefix":"10.1002","volume":"32","author":[{"given":"Ayoosh","family":"Pareek","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery and Sports Medicine Mayo Clinic Rochester Minnesota U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Reardon","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Sports Medicine Mayo Clinic Rochester Minnesota U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Macalena","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery University of Minnesota Minneapolis Minnesota U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce A.","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Sports Medicine Mayo Clinic Rochester Minnesota U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Stuart","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Sports Medicine Mayo Clinic Rochester Minnesota U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Riley J.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Institute for Cartilage Repair Hospital for Special Surgery New York New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron J.","family":"Krych","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Sports Medicine Mayo Clinic Rochester Minnesota U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,31]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509351650"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509352157"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453674.2010.519166"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/036354659602400302"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.2006.2182"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.I.00895"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.3928\/0147-7447-19980701-05"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-004-0499-3"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/jars.2003.50112"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200302000-00031"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509351143"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-009-0765-5"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-013-2676-8"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546512458763"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2005.06.018"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23999"},{"key":"e_1_2_2_18_2","doi-asserted-by":"publisher","DOI":"10.3928\/0147-7447-19980701-04"},{"key":"e_1_2_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2008.01.041"},{"key":"e_1_2_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2013.01.001"},{"key":"e_1_2_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5919(05)70130-7"},{"key":"e_1_2_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-8063(04)00590-0"},{"key":"e_1_2_2_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509360405"},{"key":"e_1_2_2_24_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.K.00815"},{"key":"e_1_2_2_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-006-0067-0"},{"key":"e_1_2_2_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_2_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/03635465010290051301"},{"key":"e_1_2_2_28_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200406000-00004"},{"key":"e_1_2_2_29_2","first-page":"43","article-title":"Rating systems in the evaluation of knee ligament injuries","author":"Tegner Y.","year":"1985","journal-title":"Clin Orthop Relat Res."},{"key":"e_1_2_2_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0b013e3181b8f6c7"},{"key":"e_1_2_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2012.06.009"},{"key":"e_1_2_2_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-012-2304-9"},{"key":"e_1_2_2_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-014-2843-6"},{"key":"e_1_2_2_34_2","doi-asserted-by":"publisher","DOI":"10.1037\/1082-989X.6.3.203"},{"key":"e_1_2_2_35_2","volume-title":"Statistical methods for meta\u2010analysis","author":"Hedges L.V.","year":"1985"},{"key":"e_1_2_2_36_2","volume-title":"Modern epidemiology","author":"Rothman K.J.","year":"2008"},{"key":"e_1_2_2_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470712184"},{"key":"e_1_2_2_38_2","first-page":"104","volume-title":"Comprehensive meta\u2010analysis version 2","author":"Borenstein M.","year":"2005"},{"key":"e_1_2_2_39_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0838.2000.010001002.x"},{"key":"e_1_2_2_40_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.15.1987"},{"key":"e_1_2_2_41_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200510000-00012"},{"key":"e_1_2_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2013.11.015"},{"key":"e_1_2_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2014.11.018"},{"key":"e_1_2_2_44_2","doi-asserted-by":"publisher","DOI":"10.1097\/JSM.0000000000000004"},{"key":"e_1_2_2_45_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.94B4.27495"},{"key":"e_1_2_2_46_2","doi-asserted-by":"publisher","DOI":"10.3928\/01477447-20140825-51"},{"key":"e_1_2_2_47_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546514539345"},{"key":"e_1_2_2_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-013-2778-3"},{"key":"e_1_2_2_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-013-3146-9"},{"key":"e_1_2_2_50_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509348000"},{"key":"e_1_2_2_51_2","first-page":"83","article-title":"The microfracture technique in the treatment of full\u2010thickness chondral lesions of the knee in National Football League players","volume":"16","author":"Steadman J.R.","year":"2003","journal-title":"J\u00a0Knee Surg"},{"key":"e_1_2_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2006.05.016"},{"key":"e_1_2_2_53_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200403000-00001"},{"key":"e_1_2_2_54_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200300002-00004"},{"issue":"1","key":"e_1_2_2_55_2","article-title":"Accelerated return to play following osteochondral autograft plug transfer (OATS)","volume":"2","author":"Gilmore C.J.","year":"2014","journal-title":"Orthop J Sports Med"},{"key":"e_1_2_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2014.12.020"},{"key":"e_1_2_2_57_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509358266"},{"key":"e_1_2_2_58_2","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5413.40250"},{"key":"e_1_2_2_59_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199910000-00011"},{"key":"e_1_2_2_60_2","article-title":"Cartilage restoration of the knee: A systematic review and meta\u2010analysis of level 1 studies","author":"Mundi R.","year":"2015","journal-title":"Am J Sports Med."},{"key":"e_1_2_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2015.09.010"},{"key":"e_1_2_2_62_2","first-page":"93","article-title":"Microfracture produces inferior outcomes to other cartilage repair techniques in chondral injuries in the paediatric knee","volume":"116","author":"Chawla A.","year":"2015","journal-title":"Br Med Bull"}],"container-title":["Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806316303267?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806316303267?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2016.05.038","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.arthro.2016.05.038","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2016.05.038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T09:26:08Z","timestamp":1773566768000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.arthro.2016.05.038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,31]]},"references-count":61,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1016\/j.arthro.2016.05.038"],"URL":"https:\/\/doi.org\/10.1016\/j.arthro.2016.05.038","archive":["Portico"],"relation":{},"ISSN":["0749-8063","1526-3231"],"issn-type":[{"value":"0749-8063","type":"print"},{"value":"1526-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,31]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Osteochondral Autograft Transfer Versus Microfracture in the Knee: A Meta-analysis of Prospective Comparative Studies at Midterm","name":"articletitle","label":"Article Title"},{"value":"Arthroscopy: The Journal of Arthroscopic & Related Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arthro.2016.05.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by the Arthroscopy Association of North America","name":"copyright","label":"Copyright"}]}}