{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:50:08Z","timestamp":1790974208282,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T00:00:00Z","timestamp":1481673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T00:00:00Z","timestamp":1481673600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T00:00:00Z","timestamp":1481673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","arthroscopyjournal.org","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare the effects of a single\u2010dose interscalene block and general anesthesia (SISB\/GA) with the effects of GA only in the early postoperative period after arthroscopic rotator cuff repair by evaluating subjective pain visual analog scale scores and objective pain\u2010related stress biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients refractory to conservative treatment of the affected shoulder were enrolled in this prospective, randomized endpoint study. Patients diagnosed with a rotator cuff tear (1\u20104\u00a0cm) based on magnetic resonance imaging were included. Exclusion criteria were small (&lt;1\u00a0cm) and massive (&gt;4\u00a0cm) rotator cuff tears. Thirty\u2010one patients each were randomized into the SISB\/GA and GA treatment groups. Preoperative pain scores were measured at 6:00 AM on the day of surgery, measured again at 1 and 6\u00a0hours postoperatively, and then every 6\u00a0hours until 3\u00a0days postoperatively. Blood sampling was performed to evaluate the stress biomarkers insulin, dehydroepiandrosterone sulfate, and fibrinogen preoperatively at 6:00 AM on the day of surgery and postoperatively at 18, 42, and 66\u00a0hours (6:00 AM on postoperative days 1\u20103).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Pain scores were significantly decreased in the SISB\/GA group (2.50 \u00b1 0.94) versus the GA group (3.82 \u00b1 1.31) on the day of surgery (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001), and especially at 6\u00a0hours postoperatively (SISB\/GA: 2.42 \u00b1 1.43; GA: 4.23 \u00b1 2.17;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001). Insulin was decreased significantly in the SISB\/GA group (10.55 \u00b1 7.92 \u03bcU\/mL) versus the GA group (20.39 \u00b1 25.60 \u03bcU\/mL) at 42\u00a0hours postoperatively (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .048). There was no significant change in dehydroepiandrosterone sulfate or fibrinogen over time (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&gt; .05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>After arthroscopic rotator cuff repair, an SISB effectively relieved pain on the day of surgery without any complications. In addition, insulin levels were significantly reduced at 42\u00a0hours postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level I, prospective randomized controlled trial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2016.09.018","type":"journal-article","created":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T17:52:11Z","timestamp":1481737931000},"page":"918-926","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Effects of a Single\u2010Dose Interscalene Block on Pain and Stress Biomarkers in Patients Undergoing Arthroscopic Rotator Cuff Repair: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"33","author":[{"given":"Xiao Ning","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Kangnam Sacred Heart Hospital Hallym University College of Medicine Seoul South Korea"},{"name":"Department of Orthopedic Surgery the Second Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Min","family":"Noh","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Wonkwang University Sanbon Hospital Wonkwang University School of Medicine Gyeonggi\u2010do South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol\u2010Jung","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Kangnam Sacred Heart Hospital Hallym University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Uk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Kangnam Sacred Heart Hospital Hallym University College of Medicine Seoul South 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