{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T10:51:22Z","timestamp":1786963882949,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T00:00:00Z","timestamp":1502150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T00:00:00Z","timestamp":1502150400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T00:00:00Z","timestamp":1502150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","arthroscopyjournal.org","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare the time to return to sport and reinjury rate after platelet\u2010rich plasma (PRP) injection versus control therapy (i.e., physiotherapy or placebo injection) in patients with acute grade I or II muscle strains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All eligible studies comparing PRP against a control in the treatment of acute (\u22647\u00a0days) grade I or II muscle strains were identified. The primary outcome was time to return to play. The secondary outcome was the rate of reinjury at a minimum of 6\u00a0months of follow\u2010up. Subgroup analysis was performed to examine the efficacy of PRP in hamstring muscle strains alone. The checklist to evaluate a report of a nonpharmacologic trial (CLEAR\u2010NPT) was used to assess the quality of studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five randomized controlled trials including a total of 268 patients with grade I and II acute muscle injuries were eligible for review. The pooled results revealed a significantly earlier return to sport for the PRP group when compared with the control group (mean difference,\u00a0\u22125.57\u00a0days [95% confidence interval,\u00a0\u22129.57 to\u00a0\u22121.58];\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .006). Subgroup analysis showed no difference in time to return to sport when comparing PRP and control therapy in grade I and II hamstring muscle strains alone (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .19). No significant difference was noted in the rate of reinjury between the 2 groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .50) at a minimum of 6\u00a0months of follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Evidence from the current literature, although limited, suggests that the use of PRP may result in an earlier return to sport among patients with acute grade I or II muscle strains without significantly increasing the risk of reinjury at 6\u00a0months of follow\u2010up. However, no difference in time to return to sport was revealed when specifically evaluating those with a grade I or II hamstring muscle strain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level II, meta\u2010analysis of level I and II studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2017.06.039","type":"journal-article","created":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T15:00:49Z","timestamp":1502204449000},"page":"281","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"title":["Does Platelet\u2010Rich Plasma Lead to Earlier Return to Sport When Compared With Conservative Treatment in Acute Muscle Injuries? A Systematic Review and Meta\u2010analysis"],"prefix":"10.1002","volume":"34","author":[{"given":"Ujash","family":"Sheth","sequence":"first","affiliation":[{"name":"University of Toronto Sports Medicine (UTOSM) Program at Women's College Hospital Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Dwyer","sequence":"additional","affiliation":[{"name":"University of Toronto Sports Medicine (UTOSM) Program at Women's College Hospital Toronto Ontario Canada"},{"name":"Division of Orthopaedic Surgery Women's College and Mount Sinai Hospital University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira","family":"Smith","sequence":"additional","affiliation":[{"name":"University of Toronto Sports Medicine (UTOSM) Program at Women's College Hospital Toronto Ontario 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