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However, as the initial hype for these therapies starts to fade, it should be replaced by solid basic and clinical science research to tailor each compound to a determined patient\/pathology. Blood contains several products that can be both beneficial and detrimental for every specific tissue, and therefore a one\u2010fits\u2010all approach should be avoided. Although beneficial effects have been consistently reported for certain pathologies such as lateral elbow tendinopathy, as an adjunct for rotator cuff repairs and the symptomatic treatment of osteoarthritis, other conditions' outcomes with biologic treatment remain nebulous such as for Achilles tendinopathy. To determine the real effect of these therapies, it is important to maintain strict inclusion criteria in an attempt to isolate the effect of one biologic product that already has many inherent intrinsic variables per se.<\/jats:p>","DOI":"10.1016\/j.arthro.2018.02.026","type":"journal-article","created":{"date-parts":[[2018,5,26]],"date-time":"2018-05-26T04:38:16Z","timestamp":1527309496000},"page":"1976-1978","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Editorial Commentary:<\/i>\n                    Hype, Hope and Everything in Between. What Produces the Real Effect for Blood\u2010derived Products Including Platelet\u2010Rich Plasma?"],"prefix":"10.1002","volume":"34","author":[{"given":"Jorge","family":"Chahla","sequence":"first","affiliation":[{"name":"Vail Colorado (R.F.L.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert F.","family":"LaPrade","sequence":"additional","affiliation":[{"name":"Vail Colorado (R.F.L.)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,1]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27016"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.16.01374"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516677547"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24153"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.03.014"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2018.01.030"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516634674"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546517741135"},{"key":"e_1_2_2_10_2","article-title":"Intra\u2010articular implantation of mesenchymal stem cells, part 1: A review of the literature for prevention of postmeniscectomy osteoarthritis","volume":"5","author":"Kraeutler M.J.","year":"2017","journal-title":"Orthop J Sports Med"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.15.01495"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.16.00793"},{"key":"e_1_2_2_13_2","doi-asserted-by":"crossref","unstructured":"Murray IR Murray AD Geeslin AG et al. 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