{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T18:26:19Z","timestamp":1773599179890,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T00:00:00Z","timestamp":1525219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T00:00:00Z","timestamp":1525219200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T00:00:00Z","timestamp":1525219200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","arthroscopyjournal.org","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To analyze the effect of cartilage fragments on tunnel widening and tendon\u2010bone integration at 2\u00a0years' follow\u2010up after anterior cruciate ligament reconstruction (ACLR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective randomized controlled study was performed in 116 patients who underwent ACLR with autologous hamstring tendons augmented with cartilage fragments (study group, n\u00a0= 56) or without any augmentation (control group, n\u00a0= 60). All patients were followed up for 25.6\u00a0months (range, 24\u201028\u00a0months), and the International Knee Documentation Committee score, Lysholm score, and visual analog scale score were determined. Computed tomography scans of all patients were obtained 2\u00a0years after surgery to evaluate the diameter of the femoral tunnel and thereby assess the amount of tunnel widening. Magnetic resonance imaging evaluation was performed 2\u00a0years postoperatively to evaluate the status of the graft in the femoral tunnel. In addition, 5 patients underwent biopsy of the tendon\u2010bone interface at 24\u00a0months postoperatively with histologic assessment and transmission electron microscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 107 patients completed the follow\u2010up. There were no significant differences between the 2 groups in terms of International Knee Documentation Committee score (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .07), Lysholm score (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .10), and visual analog scale score (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .57) at 24\u00a0months' follow\u2010up. The femoral tunnel diameter and the tunnel widening percentage in the study group were significantly smaller than those in the control group (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001). The signal\u2010noise quotient value of the graft in the femoral tunnel was 10.4 \u00b1 7.0 in the study group, which was significantly lower than that in the control group (19.5 \u00b1 9.2,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001). Histologic studies of the tendon\u2010bone interface showed that there were more bone formations containing chondroid cells with aligned connective tissue in the study group compared with the control group; in addition, the diameter of the collagen fibrils in the study group was considerably thicker than that in the control group (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The use of cartilage fragments was effective in preventing femoral tunnel widening and seemed to promote the tendon\u2010bone integration process after ACLR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level II, prospective randomized controlled study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2018.03.011","type":"journal-article","created":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T00:40:28Z","timestamp":1525308028000},"page":"2218-2227","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Effect of Cartilage Fragments on Femoral Tunnel Widening After Anterior Cruciate Ligament Reconstruction: A Prospective Randomized Controlled Study"],"prefix":"10.1002","volume":"34","author":[{"given":"Chi","family":"Zhang","sequence":"first","affiliation":[{"name":"Center for Sport Medicine First Affiliated Hospital College of Medicine Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Pan","sequence":"additional","affiliation":[{"name":"Center for Sport Medicine First Affiliated Hospital College of Medicine Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010De","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Traditional Chinese Medicine of Shaoxing Hospital Shaoxing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Sport Medicine First Affiliated Hospital College of Medicine Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng\u2010cheng","family":"Gu","sequence":"additional","affiliation":[{"name":"Center for Sport Medicine First Affiliated Hospital College of Medicine Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang\u2010jin","family":"Lin","sequence":"additional","affiliation":[{"name":"Center for Sport Medicine First Affiliated Hospital College of Medicine Zhejiang University Hangzhou 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