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Subjects were excluded from the study if they were actively taking any prescribed medications or nonsteroidal anti\u2010inflammatory drugs (NSAIDs) or if they had any of the following at present or previously: blood or immunosuppression disorders, cancer, osteonecrosis, rheumatoid arthritis, avascular necrosis, NSAID intolerance, gastrointestinal or peptic ulcer disease, or kidney dysfunction. The anabolic factors vascular endothelial growth factor, fibroblast growth factor 2, platelet\u2010derived growth factor AB (PDGF\u2010AB), and platelet\u2010derived growth factor AA (PDGF\u2010AA) and the catabolic factors interleukin (IL) 1\u03b2, IL\u20106, IL\u20108, and tumor necrosis factor \u03b1 in LR\u2010PRP were measured. Peripheral blood was drawn at 3 time points: baseline, after 1\u00a0week of naproxen use, and after a 1\u2010week washout period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The angiogenic factors PDGF\u2010AA (44% decrease in median) and PDGF\u2010AB (47% decrease) significantly declined from baseline (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05) after 1\u00a0week of naproxen use. There was a significant recovery (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05) of PDGF\u2010AA (94% increase) and PDGF\u2010AB (153% increase) levels after the 1\u2010week washout period, with a return to baseline levels. The catabolic factor IL\u20106 also had a significant decline from baseline (77% decrease in median,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05) after 1\u00a0week of naproxen use. After a 1\u2010week washout period, the IL\u20106 level was similar to the baseline level (130% increase,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Naproxen use diminished several biological factors in LR\u2010PRP; however, a 1\u2010week washout period was sufficient for the recovery of PDGF\u2010AA, PDGF\u2010AB, and IL\u20106 to return to baseline levels. Tumor necrosis factor \u03b1, IL\u20101\u03b2, IL\u20108, vascular endothelial growth factor, and fibroblast growth factor 2 did not show differences between the 3 time points of data collection. Discontinuing NSAIDs for a minimum of 1\u00a0week before LR\u2010PRP treatment may improve certain biological factor levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level II, prospective comparative study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2018.07.030","type":"journal-article","created":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T07:02:55Z","timestamp":1542870175000},"page":"201-210","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["The Influence of Naproxen on Biological Factors in Leukocyte\u2010Rich Platelet\u2010Rich Plasma: A Prospective Comparative Study"],"prefix":"10.1002","volume":"35","author":[{"given":"Sandeep","family":"Mannava","sequence":"first","affiliation":[{"name":"Center of Regenerative Sports Medicine Steadman Philippon 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