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Thus, several therapeutic approaches have been reported in the literature in an attempt to mitigate the symptoms of OA with varying degrees of success. Platelet\u2010rich plasma (PRP) is being increasingly accepted as one of the most efficacious approaches for the symptomatic treatment of mild to moderate OA. Several confounding factors can affect the outcome of PRP such as age, grade of OA, PRP processing technique, and number and timing of these injections. However, numerous reports in the literature derived from PRP randomized clinical trials (compared with saline, hyaluronic acid, and other nonsurgical methods) suggest that successful outcomes can be achieved at least at 1\u2010year postinjection with minimal complications.<\/jats:p>","DOI":"10.1016\/j.arthro.2018.07.036","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T03:04:00Z","timestamp":1546398240000},"page":"118-120","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["<i>Editorial Commentary:<\/i>\n                    Platelet\u2010Rich Plasma for Knee Osteoarthritis: A \u201cNovel\u201d and Effective Symptomatic Approach"],"prefix":"10.1002","volume":"35","author":[{"given":"Jorge","family":"Chahla","sequence":"first","affiliation":[{"name":"Rush University Medical Center (B.J.C.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian J.","family":"Cole","sequence":"additional","affiliation":[{"name":"Rush University Medical Center (B.J.C.)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,1]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11420-011-9253-9"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d1165"},{"key":"e_1_2_2_4_2","first-page":"769","article-title":"Trends in strength training\u2014United States, 1998\u20132004","volume":"55","author":"Centers for Disease Control and Prevention","year":"2006","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_2_5_2","unstructured":"Centers for Disease Control and Prevention.National Health Interview Survey (NHIS) adult sample.2012https:\/\/www.cdc.gov\/nchs\/nhis\/index.htm. 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