{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:02:56Z","timestamp":1793059376728,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["arthroscopyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine whether intravenous administration of tranexamic acid (TXA) before shoulder arthroscopic rotator cuff repair surgery can improve arthroscopy visual clarity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective, double\u2010blind, randomized, and placebo\u2010controlled study. From May 2016 to April 2018, patients requiring arthroscopic rotator cuff repair were enrolled and randomly assigned to either the TXA group. receiving 1000 mg of TXA intravenously 10 minutes before surgery. or the placebo group. receiving the same volume of plain saline. Patients with pre\u2010existing liver\/renal disease, coagulopathy, or concurrent use of anticoagulation medications were excluded. Visual clarity was rated using a Numeric Rating Scale from grade 1 (poor) to grade 3 (clear) every 15 minutes throughout the surgery. Secondary outcomes included estimated perioperative blood loss, operative time, degree of shoulder swelling, postoperative subjective pain score, inpatient duration, and associated comorbidities were recorded. Both parametric and nonparametric methods were used for the statistical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 72 patients were enrolled, 37 in the TXA group and 35 in the placebo group. The demographic data were similar between the 2 groups. Visual clarity was found to be significantly better in the TXA group, with a greater percentage of grade 3 vision clarity (53.7 \u00b1 18.9 % vs 40.5 \u00b1 22.1%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .036). The average visual score in the TXA group (2.5 \u00b1 0.2) also was better than that of the control group (2.3 \u00b1 0.3) (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .048). The postoperative subjective pain score was significantly lower in the TXA group (3.0 \u00b1 1.5) than in the control group (4.3 \u00b1 2.0) (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .009). In addition, postoperative analgesic usage was significant lower in the TXA groups (9.6 \u00b1 9.7 morphine milligram equivalent) than in the control group (14.7 \u00b1 13.4 morphine milligram equivalent) (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .037). Other parameters, such as operative time, estimated perioperative blood loss, degree of shoulder swelling, and duration of inpatient stay were similar between the 2 groups. None of the patients developed complications after surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intravenous administration of TXA is an alternative way to improve visual clarity in arthroscopic shoulder surgery. It also reduces subjective pain and analgesic consumption in the early postoperative period without significant side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Therapeutic studies level II.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2019.10.020","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T18:10:56Z","timestamp":1576865456000},"page":"640-647","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":81,"title":["Intravenous Administration of Tranexamic Acid Significantly Improved Clarity of the Visual Field in Arthroscopic Shoulder Surgery. A Prospective, Double\u2010Blind, and Randomized Controlled Trial"],"prefix":"10.1002","volume":"36","author":[{"given":"Yuan\u2010Fu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Kai","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai\u2010Lan","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Department of Biomedical Engineering National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fa\u2010Chuan","family":"Kuan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Department of Biomedical Engineering National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueh","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Sin Lau Christian Hospital Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Long","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering National Cheng Kung University Tainan Taiwan"},{"name":"Medical Device Innovation Center National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Ren","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Skeleton Materials and Bio\u2010compatibility Core Lab Research Center of Clinical Medicine National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan 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