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Treatments were compared if reported in more than one study using network meta\u2010analysis to boost the number of included studies per comparison.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We studied 21 articles that included 891 patients. Traumatic lesion was the most common cause in the included patients. There were significantly higher failure rates in the microfracture (MF) group compared to autologous chondrocyte implantation (ACI) group at 10\u2010year follow\u2010up. Moreover, osteochondral autograft transplantation (OAT) showed significantly more excellent or good results at &gt; 3\u2010year follow\u2010up compared to MF, whereas MF showed significantly more poor results versus ACI and matrix\u2010induced autologous chondrocyte implantation (MACI). Furthermore, OAT showed significantly more poor results than MACI at 1\u2010year follow\u2010up. Similarly, patients who underwent OAT had higher return\u2010to\u2010activity rates than those with MF. It is noteworthy that the Knee injury and Osteoarthritis Outcome Score was higher in patients who underwent characterized chondrocyte implantation or MACI compared to MF. Finally, there were no significant differences among the various interventions regarding reintervention, biopsy types or adverse events. According to the\n                      <jats:italic>P<\/jats:italic>\n                      scores for interventions ranking, there was a disagreement concerning the best intervention; however, MF was always ranked as the last.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cartilage repair techniques, rather than MF, provide higher quality repair of tissue and have lower failure and higher return\u2010to\u2010activity rates. Moreover, OAT had significantly more excellent or good results compared to MF, whereas MF had significantly more poor results than ACI and MACI. Future studies need to have longer follow\u2010up periods and more representative populations to investigate the efficacy and safety of these interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of evidence<\/jats:title>\n                    <jats:p>Level I: meta\u2010analysis of Level I studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2019.11.096","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T03:50:09Z","timestamp":1583121009000},"page":"845-858","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":90,"title":["Surgical Techniques for Knee Cartilage Repair: An Updated Large\u2010Scale Systematic Review and Network Meta\u2010analysis of Randomized Controlled Trials"],"prefix":"10.1002","volume":"36","author":[{"given":"Radoslav","family":"Zamborsky","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Comenius University Bratislava and the National Institute of Children\u2019s Diseases Bratislava Slovakia"},{"name":"Expert Medical Services s.r.o Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubos","family":"Danisovic","sequence":"additional","affiliation":[{"name":"Institute of Medical Biology Genetics and Clinical Genetics Comenius University Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,1]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2007.02.001"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-013-0449-3"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1947603510366701"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-201005000-00002"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-5-200009050-00007"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.1998.28.4.192"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1764-z"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200110001-00033"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-013-2614-9"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546508328414"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.L.01329"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200403000-00001"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546515593943"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.I.00895"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.K.00815"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-014-3443-1"},{"key":"e_1_2_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-013-2676-8"},{"key":"e_1_2_2_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546507311095"},{"key":"e_1_2_2_20_2","article-title":"The use of autologous chondrocyte implantation for the treatment of cartilage defects in knee joints","volume":"89","author":"National Institute for Health and Clinical Excellence","year":"2005","journal-title":"Technology Appraisal Guidance"},{"key":"e_1_2_2_21_2","first-page":"90","article-title":"Autologous cultured chondrocyte implantation in the repair of focal chondral lesions of the knee: Clinical indications and operative technique","volume":"20","author":"Minas T.","year":"1998","journal-title":"J\u00a0Sports Traumatol Relat Res"},{"key":"e_1_2_2_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003323.pub2"},{"key":"e_1_2_2_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199410063311401"},{"key":"e_1_2_2_24_2","first-page":"715","article-title":"The operative treatment of full thickness cartilage defects in the knee joint with autologous chondrocyte transplantation","volume":"21","author":"Erggelet C.","year":"2000","journal-title":"Saudi Med J"},{"key":"e_1_2_2_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000100"},{"key":"e_1_2_2_26_2","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2385"},{"key":"e_1_2_2_27_2","doi-asserted-by":"crossref","unstructured":"Abdellatif M Ghozy S Kamel MG et\u00a0al. 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