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For the second part, we planned to include 9 patients receiving the high dose for the evaluation of exploratory efficacy. Clinical outcomes were assessed according to pain, range of motion, muscle strength, functional scores, overall satisfaction and function, and presence of failure. Structural outcomes included changes in volume of tendon defects measured using magnetic resonance imaging.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study enrolled 19 patients (9 for the first part and 10 for the second part) with partial\u2010thickness rotator cuff tears. There were no treatment\u2010related adverse events at minimum 2\u2010year follow\u2010up. Intratendinous injection of AD MSCs reduced shoulder pain by approximately 90% at 1 and 2 years in the mid\u2010 and high\u2010dose groups. The strength of the supraspinatus, infraspinatus, and teres minor significantly increased by greater than 50% at 2 years in the high\u2010dose group. Shoulder function measured with 6 commonly used scores improved for up to 2 years in all dose groups. Structural outcomes evaluated with magnetic resonance imaging showed that the volume of bursal\u2010sided defects in the high\u2010dose group nearly disappeared at 1 year and did not recur at up to 2 years. No failures\u2014defined as the performance of any kind of shoulder surgery or return of the Shoulder Pain and Disability Index score to the preinjection level\u2014occurred during follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study showed continued safety and efficacy of an intratendinous injection of AD MSCs for the treatment of partial\u2010thickness rotator cuff tears over a 2\u2010year period through regeneration of tendon defects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level III, retrospective comparative study.<\/jats:p>\n                  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