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                   <jats:title>Purpose<\/jats:title>\n                    <jats:p>To identify the price of treatment at which platelet\u2010rich plasma (PRP) is cost\u2010effective relative to hyaluronic acid (HA) and saline solution intra\u2010articular injections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systemized review process of the PubMed, Embase, and MEDLINE databases was undertaken to identify randomized controlled trials comparing PRP with HA and saline solution with up to 1 year of follow\u2010up. Level I trials that reported Western Ontario and McMaster Universities Arthritis Index Likert scores were included. These scores were converted into utility scores. Cost data were obtained from Centers for Medicare &amp; Medicaid Services fee schedules. Total costs included the costs of the injectable, clinic appointments, and procedures. The change in utility scores from baseline to 6 months and 1 year for the PRP, HA, and saline solution groups was divided by total cost to determine utility gained per dollar and to identify the price needed for PRP to be cost\u2010effective relative to these other injection options.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine randomized controlled trials met the inclusion criteria. A total of 882 patients were included: 483 in the PRP group, 338 in the HA group, and 61 in the saline solution group. Baseline mean utility scores ranged from 0.55 to 0.57 for the PRP, HA, and saline solution groups. The 6\u2010month gains in utility were 0.12, 0.02, and \u20130.06, respectively. The 12\u2010month gains in utility from before injection were 0.14, 0.03, and 0.06, respectively. The lowest total costs for HA and saline solution were $681.93 and $516.29, respectively. For PRP to be cost\u2010effective, the total treatment cost would have to be less than $3,703.03 and $1,192.08 for 6\u2010 and 12\u2010month outcomes, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>For patients with symptomatic knee osteoarthritis, PRP is cost\u2010effective, from the payer perspective, at a total price (inclusive of clinic visits, the procedure, and the injectable) of less than $1,192.08 over a 12\u2010month period, relative to HA and saline solution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level I, systematic review.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2020.02.004","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T21:24:49Z","timestamp":1581629089000},"page":"1983","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["What Is the Appropriate Price for Platelet\u2010Rich Plasma Injections for Knee Osteoarthritis? 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