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Only randomized controlled trials with an experimental group that used PRP and a control group that received HA were eligible for this study. The participants were adults who had KOA. The outcome measures were the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the visual analog scale (VAS), the EuroQol VAS, the International Knee Documentation Committee, the Tegner score, the Lequesne Scale, the Knee injury Osteoarthritis Outcome Score, satisfaction rate, and adverse events. Subgroup analyses was performed for patients with different doses, types, and times of PRP interventions and grades of OA. The Review Manager Database was used to analyze the included studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010six randomized controlled trials involving 2430 patients were included. The WOMAC total scores, WOMAC physical function scores, and VAS scores of the PRP group were better than the those of the HA group at 3, 6, and 12 months. The PRP group had better WOMAC pain, WOMAC stiffness, EuroQol VAS, and International Knee Documentation Committee scores than the HA group at 6 and 12 months. There was no significant difference in adverse events between the 2 groups (relative risk 1.21, 95% confidence interval 0.95\u20101.54;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .13).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>For the nonsurgical treatment of KOA, compared with HA, intra\u2010articular injection of PRP could significantly reduce patients\u2019 early pain and improve function. There was no significant difference in adverse events between the 2 groups. PRP was more effective than HA in the treatment of KOA, and the safety of these 2 treatment options was comparable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level I, meta\u2010analysis of Level I RCTs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2020.07.011","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T02:04:47Z","timestamp":1594778687000},"page":"309-325","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":81,"title":["Platelet\n                    <i>\u2010<\/i>\n                    Rich Plasma Versus Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Meta\u2010analysis of 26 Randomized Controlled Trials"],"prefix":"10.1002","volume":"37","author":[{"given":"Jixiang","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Emergency &amp; Critical Care Medicine The First Affiliated Hospital Chongqing Medical University China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital Chongqing Medical University China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Emergency &amp; Critical Care Medicine The First Affiliated Hospital Chongqing Medical University China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital Chongqing Medical University China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,14]]},"reference":[{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/117954411000300001"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.03.018"},{"key":"e_1_2_3_4_2","doi-asserted-by":"crossref","unstructured":"Wood AM Brock TM Heil K Holmes R Weusten A. 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