{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:22:49Z","timestamp":1793294569962,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["arthroscopyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine the short\u2010term outcomes following microfracture augmented with cartilage allograft extracellular matrix for the treatment of symptomatic focal cartilage defects of the adult knee.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty\u2010eight patients enrolled by 8 surgeons from 8 separate institutions were included in this study. Patients underwent microfracture augmented by cartilage allograft extracellular matrix (BioCartilage; Arthrex, Naples, FL) and were followed at designated time points (3, 6, 12, and 24 months) to assess patient\u2010reported outcomes (PROs), clinically significant outcomes (CSOs), and failure and complication rates. Magnetic resonance imaging (MRI) was offered at 2 years postoperatively regardless of symptomatology, and Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) 2.0 score was documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PRO compliance was 81.3% at 6 months, 72.9% at 12 months, and 47.9% at 2 years. All joint\u2010specific and function\u2010related PROs significantly improved compared to baseline at 3, 6, 12, 18, and 24 months of follow\u2010up (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .01), apart from Marx activity scale, which demonstrated a significant decline in postoperative scores at 2 years (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .034). The percentage of patients achieving CSOs (as defined for microfracture) at 2 years was 90% for minimal clinically important difference and 85% for patient acceptable symptomatic state. Patient factors including age, sex, body mass index, symptoms duration, smoking, presence of a meniscal tear, lesion size, and location were not associated with CSO achievement at 2 years. One patient (2.1%) failed treatment 9.5 months postoperatively due to graft delamination and required a reoperation consisting of arthroscopic debridement. One complication (2.1%) consisting of complaints of clicking, grinding, and crepitus 15 months following the index procedure was reported. Two\u2010year postoperative MRI demonstrated a mean 40.5 \u00b1 22.9 MOCART 2.0 score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this preliminary study, we found cartilage allograft extracellular matrix to be associated with improvement in functional outcomes, high rates of CSO achievement, and low failure and complication rates at 2\u2010year follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level III, prospective multicenter cohort study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2021.01.043","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T12:42:03Z","timestamp":1612269723000},"page":"1512-1521","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Clinically Significant Outcomes Following the Treatment of Focal Cartilage Defects of the Knee With Microfracture Augmentation Using Cartilage Allograft Extracellular Matrix: A Multicenter Prospective Study"],"prefix":"10.1002","volume":"37","author":[{"given":"Brian J.","family":"Cole","sequence":"first","affiliation":[{"name":"Midwest Orthopaedics at Rush University Medical Center Chicago Illinois U.S.A."},{"name":"Orthopedic Clinic Association Phoenix Arizona U.S.A."},{"name":"Department of Clinical Sciences College of Veterinary Medicine Cornell University Ithaca New York U.S.A."},{"name":"Department of Orthopaedic Surgery Shamir Medical Center and Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Haunschild","sequence":"additional","affiliation":[{"name":"Midwest Orthopaedics at Rush University Medical Center Chicago Illinois U.S.A."},{"name":"Orthopedic Clinic Association Phoenix Arizona U.S.A."},{"name":"Department of Clinical Sciences College of Veterinary Medicine Cornell University Ithaca New York U.S.A."},{"name":"Department of Orthopaedic Surgery Shamir Medical Center and Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Carter","sequence":"additional","affiliation":[{"name":"Midwest Orthopaedics at Rush University Medical Center Chicago Illinois U.S.A."},{"name":"Orthopedic Clinic Association Phoenix Arizona U.S.A."},{"name":"Department of Clinical Sciences College of Veterinary Medicine Cornell University Ithaca New York U.S.A."},{"name":"Department of Orthopaedic Surgery Shamir Medical Center and Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Meyer","sequence":"additional","affiliation":[{"name":"Midwest Orthopaedics at Rush University Medical Center Chicago Illinois U.S.A."},{"name":"Orthopedic Clinic Association Phoenix Arizona U.S.A."},{"name":"Department of Clinical Sciences College of Veterinary Medicine Cornell University Ithaca New York U.S.A."},{"name":"Department of Orthopaedic Surgery Shamir Medical Center and Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Fortier","sequence":"additional","affiliation":[{"name":"Midwest Orthopaedics at Rush University Medical Center Chicago Illinois U.S.A."},{"name":"Orthopedic Clinic Association Phoenix Arizona U.S.A."},{"name":"Department of Clinical Sciences College of Veterinary Medicine Cornell University Ithaca New York U.S.A."},{"name":"Department of Orthopaedic Surgery Shamir Medical Center and Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Gilat","sequence":"additional","affiliation":[{"name":"Midwest Orthopaedics at Rush University Medical Center Chicago Illinois U.S.A."},{"name":"Orthopedic Clinic Association Phoenix Arizona U.S.A."},{"name":"Department of Clinical Sciences College of Veterinary Medicine Cornell University Ithaca New York U.S.A."},{"name":"Department of Orthopaedic Surgery Shamir Medical Center and Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"BC (BioCartilage) Study 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