{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T10:21:29Z","timestamp":1773570089780,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","arthroscopyjournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A growing number of knee cartilage repair studies continue to be published, employing both traditional and also novel and emerging surgical methods. Marrow stimulation, osteochondral transplantation, and autologous chondrocyte implantation via varied surgical techniques and delivery methods exist, as well as isolated, or concomitant, realignment procedures. However, while some value exists in small clinical cohorts (prospective and retrospective), we still lack high\u2010quality comparative studies that better direct us toward the ideal cartilage repair treatment, specific to each individual patient situation including chondral defect (size, location, shape, etc.), the local environment (early degenerative knee changes, concomitant pathology), the surrounding environment (including individual physical conditioning and lower\u2010limb alignment), and of course the patient\u2019s tolerance to the pathology and individual physical demands. How do we sort this out? High\u2010quality, and hopefully prospective and randomized, clinical trials are required.<\/jats:p>","DOI":"10.1016\/j.arthro.2021.02.003","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T02:19:38Z","timestamp":1622600378000},"page":"1900-1901","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Editorial Commentary:<\/i>\n                    The Number of Cartilage Treatment Options Continues to Grow, Despite the Lack of High\u2010Quality Comparative Studies?"],"prefix":"10.1002","volume":"37","author":[{"given":"Jay R.","family":"Ebert","sequence":"first","affiliation":[{"name":"University of Western Australia and HFRC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,1]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2021.01.038"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546519886548"},{"key":"e_1_2_2_4_2","article-title":"Long\u2010term prospective clinical and magnetic resonance imaging\u2010based evaluation of matrix\u2010induced autologous chondrocyte implantation","volume":"7","author":"Ebert J.R.","year":"2021","journal-title":"A m J Sports Med"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-009-1028-1"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546518756976"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546514528093"},{"key":"e_1_2_2_8_2","article-title":"A\u00a0prospective, randomized, open\u2010label, multicenter, phase III noninferiority trial to compare the clinical efficacy of matrix\u2010associated autologous chondrocyte implantation with spheroid technology versus arthroscopic microfracture for cartilage defects of the knee","volume":"7","author":"Niemeyer P.","year":"2019","journal-title":"Orthop J Sports Med"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-015-3822-2"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-017-4491-0"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2011.12.022"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516663493"},{"key":"e_1_2_2_13_2","unstructured":"J.R.Ebert M.Fallon D.J.Wood G.C.Janes.An accelerated 6\u2010week return to full weight bearing after matrix\u2010induced autologous chondrocyte implantation results in good clinical outcomes to 5 years post\u2010surgery [published online January 18 2021].Knee Surg Sports Traumatol Arthroschttps:\/\/doi.org\/10.1007\/s00167\u2010020\u201006422\u20106"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546514554910"}],"container-title":["Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806321001365?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806321001365?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2021.02.003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.arthro.2021.02.003","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2021.02.003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T09:06:21Z","timestamp":1773565581000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.arthro.2021.02.003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1016\/j.arthro.2021.02.003"],"URL":"https:\/\/doi.org\/10.1016\/j.arthro.2021.02.003","archive":["Portico"],"relation":{},"ISSN":["0749-8063","1526-3231"],"issn-type":[{"value":"0749-8063","type":"print"},{"value":"1526-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This 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