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Outcome assessment included the visual analog scale (VAS) score, Western Ontario and McMaster Universities Osteoarthritis (WOMAC) pain subscore, WOMAC score, International Knee Documentation Committee (IKDC) subjective score, and treatment\u2010related AEs. Main inclusion criteria were at least one of the aforementioned outcome measurements, a minimum follow\u2010up period of 5 months, and &gt;80% patient follow\u2010up. Treatments combined with the use of other operations or drugs were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty\u2010three studies meeting the eligibility criteria were included. At 6 months, VAS scores and WOMAC pain subscores showed that AD\u2010MSCs were the best treatment option (surface under the cumulative ranking curve [SUCRA]\u00a0= 96.7%, SUCRA\u00a0= 85.3%, respectively). According to WOMAC scores and subjective IKDC scores, LP\u2010PRP was the most effective treatment (SUCRA\u00a0= 86.0%, SUCRA\u00a0= 80.5%, respectively). At 12 months, only AD\u2010MSCs were associated with improved VAS scores compared with the placebo (weighted mean difference [WMD]\u00a0= \u201320.93, 95% credibility interval [CrI], \u201341.71 to \u20130.78). Both LP\u2010PRP and AD\u2010MSCs were more beneficial than the placebo for improving WOMAC pain subscores (WMD\u00a0= \u201330.08; 95% CrI, \u201353.59 to \u20136.25; WMD\u00a0= \u201334.85; 95% CrI, \u201368.03 to \u20134.86, respectively). For WOMAC scores, LP\u2010PRP and LR\u2010PRP were significantly associated with improved WOMAC scores compared with the placebo after sensitivity analysis was performed (WMD\u00a0= \u201335.26; 95% CrI, \u201364.99 to \u20136.01; WMD\u00a0= \u201338.69; 95% CrI, \u201376.21 to \u20132.76). LP\u2010PRP exhibited relatively better efficacy in improving subjective IKDC scores than the placebo (WMD\u00a0= 13.67; 95% CrI, 4.05\u201023.39). Regarding safety, all treatments except for LP\u2010PRP (relative risk\u00a0= 1.83; 95% CrI, 0.89\u20104.64) increased treatment\u2010related AEs compared with the placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Based on the results of current research findings, during 6 months of follow\u2010up, AD\u2010MSCs relieved pain the best; LP\u2010PRP was most effective for functional improvement. During the 12\u2010month follow\u2010up, both AD\u2010MSCs and LP\u2010PRP showed potential clinical pain relief effects; functional improvement was achieved with LP\u2010PRP. Unfortunately, AD\u2010MSC\/LP\u2010PRP functional comparisons were only based on WOMAC scores due to missing IKDC scores. BM\u2010MSCs seem to have potentially beneficial effects, but the wide credibility interval makes it impossible to draw a well\u2010supported conclusion. HA viscosupplementation clinical efficacy was lower than that of biological agents during follow\u2010up, which may be related to the properties of the drugs. Considering the evaluation of treatment\u2010related AEs, LP\u2010PRP is the most advisable choice; although the AEs of these treatments are not serious, they may affect treatment compliance and satisfaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level II, meta\u2010analysis of Level I and II studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2021.02.045","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T22:53:48Z","timestamp":1615416828000},"page":"2298","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"title":["Intra\u2010Articular Injections of Platelet\u2010Rich Plasma, Adipose Mesenchymal Stem Cells, and Bone Marrow Mesenchymal Stem Cells Associated With Better Outcomes Than Hyaluronic Acid and Saline in Knee Osteoarthritis: A Systematic Review and Network Meta\u2010analysis"],"prefix":"10.1002","volume":"37","author":[{"given":"Di","family":"Zhao","sequence":"first","affiliation":[{"name":"Guangzhou University of Chinese Medicine Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010ke","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010hong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 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