{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:41:02Z","timestamp":1785498062618,"version":"3.56.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["arthroscopyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tissue engineering requires cells, scaffolds, growth factors, and mechanical stimulation. In terms of cartilage restoration or repair, various innovative approaches are evolving, using host or allograft cells, biomimetic scaffolds, matrices, or membranes including hyaluronic acid, as well as diverse biological and growth factors. A current approach for the treatment of chondral or osteochondral defects enhances a microfracture procedure (introducing autologous, mesenchymal stem cells) with dehydrated micronized allograft extracellular matrix (scaffold), platelet\u2010rich plasma (containing anabolic, anticatabolic, and anti\u2010inflammatory growth factors), a fibrin glue sealant, and careful rehabilitation providing mechanical stimulation. Early results are encouraging; long\u2010term outcomes including a larger number of study subjects remain to be reported.<\/jats:p>","DOI":"10.1016\/j.arthro.2021.03.014","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T20:18:58Z","timestamp":1619122738000},"page":"1359-1360","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Articular Cartilage Restoration Requires Cells, Scaffolds, Growth Factors, and Mechanical Stimulation"],"prefix":"10.1002","volume":"37","author":[{"given":"Mark G.","family":"Siegel","sequence":"first","affiliation":[{"name":"Associate Editor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H.","family":"Lubowitz","sequence":"additional","affiliation":[{"name":"Editor\u2010in\u2010Chief"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jefferson C.","family":"Brand","sequence":"additional","affiliation":[{"name":"Assistant Editor\u2010in\u2010Chief"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Rossi","sequence":"additional","affiliation":[{"name":"Assistant Editor\u2010in\u2010Chief"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,1]]},"reference":[{"key":"e_1_2_2_2_2","unstructured":"Goodreads. Quotable quotes. Fyodor Dostoevsky.White Nightshttps:\/\/www.goodreads.com\/quotes\/132640\u2010my\u2010god\u2010a\u2010moment\u2010of\u2010bliss\u2010why\u2010isn\u2010t\u2010that\u2010enough. Accessed March 1 2021."},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2015.02.038"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1938640010388602"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546514530292"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546511399382"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2019.12.004"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509331419"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2019.11.110"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2020.02.026"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2021.01.043"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eats.2017.06.018"},{"key":"e_1_2_2_13_2","doi-asserted-by":"crossref","unstructured":"Commins J Irwin R Matuska A Goodale M Delco M Fortier L. Biological mechanisms for cartilage repair using a biocartilage scaffold: Cellular adhesion\/migration and bioactive proteins [published online January 22 2021].Cartilagedoi:10.1177\/1947603519900803.","DOI":"10.1177\/1947603519900803"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516648644"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2020.07.087"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcot.2017.08.017"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstl.1742.0079"},{"key":"e_1_2_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2019.12.020"},{"key":"e_1_2_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2018.07.017"}],"container-title":["Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S074980632100236X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S074980632100236X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2021.03.014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.arthro.2021.03.014","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2021.03.014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T08:49:51Z","timestamp":1773564591000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.arthro.2021.03.014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1016\/j.arthro.2021.03.014"],"URL":"https:\/\/doi.org\/10.1016\/j.arthro.2021.03.014","archive":["Portico"],"relation":{},"ISSN":["0749-8063","1526-3231"],"issn-type":[{"value":"0749-8063","type":"print"},{"value":"1526-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Articular Cartilage Restoration Requires Cells, Scaffolds, Growth Factors, and Mechanical Stimulation","name":"articletitle","label":"Article Title"},{"value":"Arthroscopy: The Journal of Arthroscopic & Related Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arthro.2021.03.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by the Arthroscopy Association of North America","name":"copyright","label":"Copyright"}]}}