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The potential to augment the healing environment at a surgical repair site is an especially exciting possibility. There are a few popular biological agents, including platelet\u2010rich plasma, concentrated bone marrow aspirate (BMA), and adipose\u2010derived connective tissue progenitor cells. BMA is an especially appealing biological agent because it can be harvested from a variety of sources, including the iliac crest, distal femur, and proximal humerus. As a result, BMA is readily accessible with minimal added surgical time and morbidity during surgical procedures on the hip, knee, and shoulder. In particular, the surgically repaired rotator cuff tendon is a prime candidate for biological augmentation, and the proximal humerus is an appealing source of concentrated BMA given its ease of access and low harvesting morbidity at the time of arthroscopic repair. The nucleated cell count may be considered a surrogate for the quality of BMA and can be readily calculated at the time of harvest. However, the quantity of nucleated cells does not necessarily equate to the quality of nucleated cells as colony\u2010forming units after cell culture, nor do we know how ex\u00a0vivo cell culture correlates with in\u00a0vivo stem cell proliferation and healing. Most of all, future research must determine what factors (if any) do positively correlate with the number of colony\u2010forming units.<\/jats:p>","DOI":"10.1016\/j.arthro.2021.03.017","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T03:08:21Z","timestamp":1625195301000},"page":"2053-2054","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Editorial Commentary:<\/i>\n                    Shoulder Rotator Cuff Tendon Repair Using Bone Marrow Aspirate: Stem Cell Quantity Does Not Equal Quality"],"prefix":"10.1002","volume":"37","author":[{"suffix":"II","given":"James B.","family":"Carr","sequence":"first","affiliation":[{"name":"West Palm Beach Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,1]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2021.01.064"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2007.03.020"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2017.10.040"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v6.i2.211"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2020.06.009"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2016.12.013"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-014-2391-1"}],"container-title":["Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806321002395?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806321002395?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2021.03.017","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.arthro.2021.03.017","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2021.03.017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T08:44:49Z","timestamp":1773564289000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.arthro.2021.03.017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":7,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1016\/j.arthro.2021.03.017"],"URL":"https:\/\/doi.org\/10.1016\/j.arthro.2021.03.017","archive":["Portico"],"relation":{},"ISSN":["0749-8063","1526-3231"],"issn-type":[{"value":"0749-8063","type":"print"},{"value":"1526-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Editorial Commentary: Shoulder Rotator Cuff Tendon Repair Using Bone Marrow Aspirate: Stem Cell Quantity Does Not Equal Quality","name":"articletitle","label":"Article Title"},{"value":"Arthroscopy: The Journal of Arthroscopic & Related Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arthro.2021.03.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by the Arthroscopy Association of North America","name":"copyright","label":"Copyright"}]}}