{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:19:25Z","timestamp":1791591565947,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T00:00:00Z","timestamp":1618531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T00:00:00Z","timestamp":1618531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T00:00:00Z","timestamp":1618531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T00:00:00Z","timestamp":1618531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007307","name":"Arthrex","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007307","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008426","name":"DePuy Mitek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005563","name":"Research Triangle Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005563","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004830","name":"Siemens","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004830","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["arthroscopyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To describe the complications that occur following biologic therapeutic injections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We queried physician members of the Biologic Association, a multidisciplinary organization dedicated to providing a unified voice for all matters related to musculoskeletal biologics and regenerative medicine. Patients included in this study must have (1) received a biologic injection, (2) sustained an adverse reaction, and (3) had a minimum of 1\u2010year follow\u2010up after the injection. Patient demographic information, medical comorbidities, diagnoses, and previous treatments were recorded. The type of injection, injection setting, injection manufacturers, and specific details about the complication and outcome were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 14 patients were identified across 6 institutions in the United States (mean age 63 years, range: 36\u201083 years). The most common injections in this series were intra\u2010articular knee injections (50%), followed intra\u2010articular shoulder injections (21.4%). The most common underlying diagnosis was osteoarthritis (78.5%). Types of injections included umbilical cord blood, platelet\u2010rich plasma, bone marrow aspirate concentrate, placental tissue, and unspecified \u201cstem cell\u201d injections. Complications included infection (50%), suspected sterile inflammatory response (42.9%), and a combination of both (7.1%). The most common pathogen identified from infection cases was\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                      (n\u00a0= 4). All patients who had isolated infections underwent treatment with at least one subsequent surgical intervention (mean: 3.6, range: 1\u201012) and intravenous antibiotic therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrates that serious complications can occur following treatment with biologic injections, including infections requiring multiple surgical procedures and inflammatory reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level IV, case series.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2021.03.065","type":"journal-article","created":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T22:45:35Z","timestamp":1618699535000},"page":"2600-2605","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Complications Following Biologic Therapeutic Injections: A Multicenter Case Series"],"prefix":"10.1002","volume":"37","author":[{"given":"Claire D.","family":"Eliasberg","sequence":"first","affiliation":[{"name":"Hospital for Special Surgery New York New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Nemirov","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University Philadelphia Pennsylvania U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert R.","family":"Mandelbaum","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Kerlan\u2010Jobe Institute Santa Monica California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Pearle","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery New York New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Tokish","sequence":"additional","affiliation":[{"name":"Mayo Clinic Arizona Phoenix Arizona U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Baria","sequence":"additional","affiliation":[{"name":"Ohio State University Columbus Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Millett","sequence":"additional","affiliation":[{"name":"Steadman Clinic Vail Colorado U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane A.","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Mayo Clinic Florida Jacksonville Florida 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