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A comprehensive literature search was conducted in September 2019 and repeated in April 2020 using electronic databases PubMed, MEDLINE, and the Cochrane Library. Baseline and 3\u2010, 6\u2010, and 12\u2010month data were extracted for visual analog scale (VAS), Disabilities of the Arm, Shoulder, and Hand (DASH), and modified Mayo Clinic performance index for the elbow (MAYO) scores. Only level 1 studies with patients who had not undergone surgery were included. Outcomes data, study design, demographic variables, PRP formulation, and comparator treatments were recorded. Statistical analyses of pooled weighted mean differences (WMDs) were performed and compared with estimated minimal clinically important difference (MCID) values. The Coleman Methodology Score (CMS) was used to assess methodological quality, and the Cochrane risk\u2010of\u2010bias assessment was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This review included 16 level I studies, 9 of which (581 total patients, 281 receiving single injections of PRP) were quantitatively analyzed. The average age was 41.5 years, 56.8% of patients were female, and mean follow\u2010up was 7.5 months. The mean CMS was 78.94 \u00b1 12.74 (range 59 to 97), and 5 of 16 studies were at low risk for bias. Patients who received PRP had significantly improved VAS scores at 3 months (WMD \u20130.85; 95% confidence interval [CI] \u20131.03, \u20130.66;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .01) and 6 months (WMD \u20130.74; 95% CI\u00a0\u20130.98, \u20130.50;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .01) compared with those who received autologous whole blood, though MAYO scores were statistically equivalent. Comparing PRP to corticosteroids, VAS and DASH scores were not significantly different at 3 months, although PRP was superior at 6 months for VAS (WMD \u20131.70; 95% CI \u20132.65, \u20130.75;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .01) and DASH (WMD \u20136.23; 95% CI \u201310.78, \u20131.69;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .01). Most differences in VAS and DASH scores exceeded the 5% absolute difference estimate for their respective MCIDs but fell short of the 10% estimate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Considering the small number of comparable studies, lack of quantification of specific PRP content, considerable heterogeneity between randomized control trials, and most effect sizes being equivocal within the framework of 2 estimated MCID values, the authors can neither scientifically support nor discourage the usage of PRP for lateral epicondylitis despite finding statistically significant improvements in pain and functional outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>I, prognostic.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2021.04.061","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T02:24:31Z","timestamp":1620181471000},"page":"2937-2952","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["The Efficacy of Platelet\u2010Rich Plasma for Improving Pain and Function in Lateral Epicondylitis: A\u00a0Systematic Review and Meta\u2010analysis with Risk\u2010of\u2010Bias Assessment"],"prefix":"10.1002","volume":"37","author":[{"given":"Xiao T.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Keck School of Medicine of USC Los Angeles California U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Keck School of Medicine of USC Los Angeles California U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian A.","family":"Jones","sequence":"additional","affiliation":[{"name":"University of California Irvine School of Medicine Irvine California U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathanael D.","family":"Heckmann","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Keck School of Medicine of USC Los Angeles California U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caron","family":"Park","sequence":"additional","affiliation":[{"name":"Southern California Clinical and Translational Science Institute Los Angeles California U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"C. 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