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Bone marrow aspirate concentrate provides growth factors to the injury site, such as vascular endothelial growth factor, platelet\u2010derived growth factor, transforming growth factor\u2010\u03b2a, and bone morphogenetic proteins in addition to the mesenchymal stem cells present in the concentrate. Cellular\u2010based therapies like mesenchymal stem cells are becoming more widely used in conjunction with surgical treatment of focal cartilage lesions with early promising results. Both treatment options improve clinical and radiographic outcomes. As for the efficacy of mesenchymal stem cells versus bone marrow aspirate concentrate, we believe that both have promising results.<\/jats:p>","DOI":"10.1016\/j.arthro.2021.05.056","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T03:12:55Z","timestamp":1627873975000},"page":"2531-2532","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>Editorial Commentary<\/i>\n                    : When Treating Cartilage Lesions With Osseous Involvement, Biologic \u201cChondrofacilitation\u201d Using Either Bone Marrow Aspirate Concentrate or Mesenchymal Stem Cells Augments Microfracture"],"prefix":"10.1002","volume":"37","author":[{"given":"Mathew J.","family":"Hamula","sequence":"first","affiliation":[{"name":"Flushing Meadows New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bert R.","family":"Mandelbaum","sequence":"additional","affiliation":[{"name":"Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,1]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2021.02.022"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-78051-7_7"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1947603517746722"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198707163170304"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jme.2005.015339"}],"container-title":["Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806321005697?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806321005697?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2021.05.056","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.arthro.2021.05.056","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2021.05.056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T09:13:00Z","timestamp":1773565980000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.arthro.2021.05.056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":5,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1016\/j.arthro.2021.05.056"],"URL":"https:\/\/doi.org\/10.1016\/j.arthro.2021.05.056","archive":["Portico"],"relation":{},"ISSN":["0749-8063","1526-3231"],"issn-type":[{"value":"0749-8063","type":"print"},{"value":"1526-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Editorial Commentary: When Treating Cartilage Lesions With Osseous Involvement, Biologic \u201cChondrofacilitation\u201d Using Either Bone Marrow Aspirate Concentrate or Mesenchymal Stem Cells Augments Microfracture","name":"articletitle","label":"Article Title"},{"value":"Arthroscopy: The Journal of Arthroscopic & Related Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arthro.2021.05.056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier on behalf of the Arthroscopy Association of North America","name":"copyright","label":"Copyright"}]}}