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Options include drugs, surgical intervention, scaffolds, biologics as a product of cells, and physical and electromagnetic stimuli. The goal of regenerative medicine is to enhance the healing of tissue after musculoskeletal injuries as both isolated treatment and adjunct to surgical management, using novel therapies to improve recovery and outcomes. Various orthopaedic biologics (orthobiologics) have been investigated for the treatment of pathology involving the hip, including osteonecrosis (aseptic necrosis) involving bone marrow, bone, and cartilage, and chondral injuries involving articular cartilage, synovium, and bone marrow. Promising and established treatment modalities for osteonecrosis include nonweightbearing; pharmacological treatments including low molecular\u2010weight heparin, prostacyclin, statins, bisphosphonates, and denosumab, a receptor activator of nuclear factor\u2010kB ligand inhibitor; extracorporeal shock wave therapy; pulsed electromagnetic fields; core decompression surgery; cellular therapies including bone marrow aspirate comprising mesenchymal stromal cells (MSCs aka mesenchymal stem cells) and bone marrow autologous concentrate, with or without expanded or cultured cells, and possible addition of bone morphogenetic protein\u20102, vascular endothelial growth factor, and basic fibroblast growth factor; and arterial perfusion of MSCs that may be combined with addition of carriers or scaffolds including autologous MSCs cultured with beta\u2010tricalcium phosphate ceramics associated with a free vascularized fibula. Promising and established treatment modalities for chondral lesions include autologous platelet\u2010rich plasma; hyaluronic acid; MSCs (in expanded or nonexpanded form) derived from bone marrow or other sources such as fat, placenta, umbilical cord blood, synovial membrane, and cartilage; microfracture or microfracture augmented with membrane containing MSCs, collagen, HA, or synthetic polymer; mosaicplasty; 1\u2010stage autologous cartilage translation (ACT) or 2\u2010stage ACT using 3\u2010dimensional spheroids; and autologous cartilage grafting; chondral flap repair, or flap fixation with fibrin glue. Hip pain is catastrophic in young patients, and promising therapies offer an alternative to premature arthroplasty. This may address both physical and psychological components of pain; the goal is to avoid or postpone an artificial joint.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level V, expert opinion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2021.08.032","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T04:02:47Z","timestamp":1631073767000},"page":"643-656","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Nonoperative and Operative Bone and Cartilage Regeneration and Orthopaedic Biologics of the Hip: An Orthoregeneration Network (ON) Foundation Hip\u00a0Review"],"prefix":"10.1002","volume":"38","author":[{"given":"Jacques","family":"Hernigou","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery EpiCURA Hospital Baudour"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Verdonk","sequence":"additional","affiliation":[{"name":"ORTHOCA Antwerp"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Homma","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Juntendo University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Verdonk","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics &amp; Trauma ULB University Clinic Erasme Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart B.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Stanford University Medical Center Outpatient Center Stanford California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Hernigou","sequence":"additional","affiliation":[{"name":"Hospital Henri Mondor University Paris East Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,7]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-015-3101-3"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1669-x"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546511398040"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000150118.42360.1d"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.4055\/cios.2016.8.1.1"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-014-1997-5"},{"key":"e_1_2_2_8_2","unstructured":"Orthoregeneration Network Glossaryhttps:\/\/my.onfoundation.org\/Glossary. 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